Postconditioning the Heart: Analysis of Experimental and Clinical Data

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Abstract

Experimental atherosclerosis and hypercholesterolemia may reduce or eliminate the infarct-limiting and anti-apoptotic effect of postconditioning (PC). Experiments in rats and mice indicate that the PC may be quite effective in patients with diabetes type 2 or metabolic syndrome. Experimental data suggest that hypertension or the past myocardial infarction is not an obstacle for the implementation of cardioprotective effect of PC. It was established that that aging does not preclude the implementation of PC cardioprotective effect. Inotropic effect of IP can simulate on isolated human atrial trabeculae. The clinical observations suggest that the PC in patients with tetralogy of Fallot and patients with operations on the valves improves the outcome of cardiac surgery. It was established that PC in these patients reduces the intensity of reperfusion necrosis of cardiomyocytes, improves the pumping function of the heart, reduces the inotropic support, shorten the extubation time.

About the authors

L. N. Maslov

Research Institute for Cardiology, Tomsk

Author for correspondence.
Email: Maslov@cardio-tomsk.ru
MD, PhD, Professor Россия

S. Yu. Tsibul'nikov

Research Institute for Cardiology, Tomsk

Email: Tsibulnikov@outlook.com
MD, PhD Россия

A. V. Mukhomedzyanov

Research Institute for Cardiology, Tomsk

Email: sasha_m91@mail.ru
MD Россия

A. S. Semenotsov

Research Institute for Cardiology, Tomsk

Email: hamkot@sibmail.com
MD Россия

A. V. Tsepokina

Research Institute of Complex Problems of Cardiovascular Disease, Kemerovo

Email: annacepokina@mail.ru
PhD-student Россия

M. V. Khutornaya

Research Institute of Complex Problems of Cardiovascular Disease, Kemerovo

Email: masha_hut@mail.ru
PhD-student Россия

A. G. Kutikhin

Research Institute of Complex Problems of Cardiovascular Disease, Kemerovo

Email: antonkutikhin@gmail.com
PhD-student Россия

I. F. Nam

Tomsk Polytechnic University, Tomsk

Email: irenanam@gmail.com
PhD, Assistance professor Россия

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