Postconditioning the Heart: Analysis of Experimental and Clinical Data

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  • Authors: Maslov L.N.1, Tsibul'nikov S.Y.1, Mukhomedzyanov A.V.1, Semenotsov A.S.1, Tsepokina A.V.2, Khutornaya M.V.2, Kutikhin A.G.2, Nam I.F.3
  • Affiliations:
    1. Research Institute for Cardiology, Tomsk
    2. Research Institute of Complex Problems of Cardiovascular Disease, Kemerovo
    3. Tomsk Polytechnic University, Tomsk
  • Issue: Vol 71, No 1 (2016)
  • Pages: 25-30
  • Section: CARDIOLOGY AND CARDIOVASCULAR SURGERY: CURRENT ISSUES
  • URL: https://vestnikramn.spr-journal.ru/jour/article/view/628
  • DOI: https://doi.org/10.15690/vramn628
  • Cite item

Abstract


Experimental atherosclerosis and hypercholesterolemia may reduce or eliminate the infarct-limiting and anti-apoptotic effect of postconditioning (PC). Experiments in rats and mice indicate that the PC may be quite effective in patients with diabetes type 2 or metabolic syndrome. Experimental data suggest that hypertension or the past myocardial infarction is not an obstacle for the implementation of cardioprotective effect of PC. It was established that that aging does not preclude the implementation of PC cardioprotective effect. Inotropic effect of IP can simulate on isolated human atrial trabeculae. The clinical observations suggest that the PC in patients with tetralogy of Fallot and patients with operations on the valves improves the outcome of cardiac surgery. It was established that PC in these patients reduces the intensity of reperfusion necrosis of cardiomyocytes, improves the pumping function of the heart, reduces the inotropic support, shorten the extubation time.


L. N. Maslov

Research Institute for Cardiology, Tomsk

Author for correspondence.
Email: Maslov@cardio-tomsk.ru

Russian Federation MD, PhD, Professor

S. Yu. Tsibul'nikov

Research Institute for Cardiology, Tomsk

Email: Tsibulnikov@outlook.com

Russian Federation MD, PhD

A. V. Mukhomedzyanov

Research Institute for Cardiology, Tomsk

Email: sasha_m91@mail.ru

Russian Federation MD

A. S. Semenotsov

Research Institute for Cardiology, Tomsk

Email: hamkot@sibmail.com

Russian Federation MD

A. V. Tsepokina

Research Institute of Complex Problems of Cardiovascular Disease, Kemerovo

Email: annacepokina@mail.ru

Russian Federation PhD-student

M. V. Khutornaya

Research Institute of Complex Problems of Cardiovascular Disease, Kemerovo

Email: masha_hut@mail.ru

Russian Federation PhD-student

A. G. Kutikhin

Research Institute of Complex Problems of Cardiovascular Disease, Kemerovo

Email: antonkutikhin@gmail.com

Russian Federation PhD-student

I. F. Nam

Tomsk Polytechnic University, Tomsk

Email: irenanam@gmail.com

Russian Federation PhD, Assistance professor

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