The Possibilities of Cell Technologies in the Treatment of Cicatricial Lesions of the Vocal Folds

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Abstract

The article is a brief review of publications devoted to the problem of persistent dysphonia. The main cause of voice disorders is the scarring of the vocal folds resulting from trauma, surgical manipulation, inflammatory process. Treatment of cicatricial lesions of the vocal folds remains a challenge, as far as existing methods do not ensure the recovery of the ultrastructure of the vocal folds. The authors present modern data on the structure of the vocal folds at the cellular level. Considered pathologic processes occur in different stages of scarring. Applied technologies of phonosurgery and conservative treatment, their effectiveness and shortcomings are covered. Analysis of experimental research conducted in the world demonstrates the promise of using the methods of tissue engineering to treat scarring of the vocal folds and to restore the microstructure of the latter. Identified current issues remain unresolved, which leads to the need for further experimental and clinical studies in the treatment of this pathology.

About the authors

V. M. Svistushkin

I.M. Sechenov First Moscow State Medical University

Email: svvm3@yandex.ru
Valeriy Mikhailovich Svistushkin - MD, Professor, head of the ENT department Россия

S. V. Starostina

I.M. Sechenov First Moscow State Medical University

Email: starostina_sv@inbox.ru
Svetlana Viktorovna Starostina - MD, Professor of the ENT department Россия

A. V. Lyundup

I.M. Sechenov First Moscow State Medical University

Author for correspondence.
Email: lyundup@gmail.com
Aleksey Valerievich Lyundup - PhD, head of the department of Biomedical Research Institute of molecular medicine Россия

M. G. Dedova

I.M. Sechenov First Moscow State Medical University

Email: dedova.marica@mail.ru
Mariya Georgievna Dedova - Assistant of the ENT department Россия

L. S. Budeikina

I.M. Sechenov First Moscow State Medical University

Email: doc.budeykina@gmail.com
Liliya Sergeevna Budeikina - Resident of the ENT department Россия

M. V. Svistushkin

I.M. Sechenov First Moscow State Medical University

Email: svistmih@live.ru
Mikhail Valerievich Svistushkin - Student Россия

M. E. Krasheninnikov

I.M. Sechenov First Moscow State Medical University

Email: krashen@rambler.ru
Mikhail Evgenievich Krasheninnikov - PhD, Biomedical Research Institute of molecular medicine Россия

D. S. Baranovskiy

I.M. Sechenov First Moscow State Medical University

Email: dennissb@mail.ru
Denis Stanislavovich Baranovskiy - PhD student of the department of Biomedical Research Institute of molecular medicine Россия

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