Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC58610.15690/vramn586CELL TRANSPLANTOLOGY AND TISSUE ENGINEERING: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ КЛЕТОЧНОЙ ТРАНСПЛАНТОЛОГИИ И ТКАНЕВОЙ ИНЖЕНЕРИИThe Possibilities of Cell Technologies in the Treatment of Cicatricial Lesions of the Vocal FoldsВозможности клеточных технологий в лечении рубцовых поражений голосовых складокSvistushkinV. M.СвистушкинВалерий Михайлович
Russian Federation

Valeriy Mikhailovich Svistushkin - MD, Professor, head of the ENT department

Доктор медицинских наук, профессор, заведующий кафедрой оториноларингологии

Адрес: 119991, Москва, ул. Б. Пироговская, д. 6, стр. 1

svvm3@yandex.ruStarostinaS. V.СтаростинаСветлана Викторовна
Russian Federation

Svetlana Viktorovna Starostina - MD, Professor of the ENT department

Доктор медицинских наук, профессор кафедры оториноларингологии

Адрес: 119991, Москва, ул. Б. Пироговская, д. 6, стр. 1

starostina_sv@inbox.ruLyundupA. V.ЛюндупАлексей Валерьевич
Russian Federation

Aleksey Valerievich Lyundup - PhD, head of the department of Biomedical Research Institute of molecular medicine

Кандидат медицинских наук, заведующий отделом биомедицинских исследований НИИ молекулярной медицины

Адрес: 119992, Москва, ул. Трубецкая, д. 8, стр. 2

lyundup@gmail.comDedovaM. G.ДедоваМария Георгиевна
Russian Federation

Mariya Georgievna Dedova - Assistant of the ENT department

Ассистент кафедры оториноларингологии

Адрес: 119991, Москва, ул. Б. Пироговская, д. 6, стр. 1

dedova.marica@mail.ruBudeikinaL. S.БудейкинаЛилия Сергеевна
Russian Federation

Liliya Sergeevna Budeikina - Resident of the ENT department

Клинический ординатор кафедры оториноларингологии

Адрес: 119991, Москва, ул. Б. Пироговская, д. 6, стр. 1

doc.budeykina@gmail.comSvistushkinM. V.СвистушкинМихаил Валерьевич
Russian Federation

Mikhail Valerievich Svistushkin - Student

Студент 6-го курса ЦИОП «Медицина будущего»

Адрес: 119991, Москва, ул. Б. Пироговская, д. 6, стр. 1

svistmih@live.ruKrasheninnikovM. E.КрашенинниковМихаил Евгеньевич
Russian Federation

Mikhail Evgenievich Krasheninnikov - PhD, Biomedical Research Institute of molecular medicine

Кандидат биологических наук, старший научный сотрудник отдела биомедицинских исследований НИИ молекулярной медицины

Адрес: 119992, Москва, ул. Трубецкая, д. 8, стр. 2

krashen@rambler.ruBaranovskiyD. S.БарановскийДенис Станиславович
Russian Federation

Denis Stanislavovich Baranovskiy - PhD student of the department of Biomedical Research Institute of molecular medicine

Аспирант отдела биомедицинских исследований НИИ молекулярной медицины

Адрес: 119992, Москва, ул. Трубецкая, д. 8, стр. 2

dennissb@mail.ruI.M. Sechenov First Moscow State Medical UniversityПервый Московский государственный медицинский университет им. И.М. Сеченова, Москва120720167132412201520062016Copyright ©; 2016, "Paediatrician" Publishers LLCCopyright ©; 2016, Издательство "Педиатръ"2016"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/586

The article is a brief review of publications devoted to the problem of persistent dysphonia. The main cause of voice disorders is the scarring of the vocal folds resulting from trauma, surgical manipulation, inflammatory process. Treatment of cicatricial lesions of the vocal folds remains a challenge, as far as existing methods do not ensure the recovery of the ultrastructure of the vocal folds. The authors present modern data on the structure of the vocal folds at the cellular level. Considered pathologic processes occur in different stages of scarring. Applied technologies of phonosurgery and conservative treatment, their effectiveness and shortcomings are covered. Analysis of experimental research conducted in the world demonstrates the promise of using the methods of tissue engineering to treat scarring of the vocal folds and to restore the microstructure of the latter. Identified current issues remain unresolved, which leads to the need for further experimental and clinical studies in the treatment of this pathology.

Статья представляет собой краткий обзор публикаций мировой литературы, посвященных исследованиям по использованию методов регенеративной медицины в лечении рубцовых поражений голосовых складок. Патологические изменения голосовых складок, возникающие в результате травм, хирургических манипуляций, воспалительного процесса, являются одной из наиболее частых причин стойкой дисфонии. Результаты лечения рубцовых поражений голосовых складок инъекционно-имплантационным методом существенно ограничены в связи с тем, что не обеспечивают восстановления ультраструктуры голосовой складки. Авторами изложены современные данные о строении голосовых складок на клеточном уровне. Рассмотрены патологические процессы, происходящие в разные стадии рубцевания. Освещены применяемые технологии фонохирургии и консервативного лечения, их эффективность и недостатки. Представлен анализ экспериментальных исследований, проводимых в мире, демонстрирующих возможности клеточных технологий в восстановлении микроструктуры голосовых складок, что может быть использовано для лечения стойкой дисфонии. Обозначены актуальные, остающиеся нерешенными вопросы, что обусловливает необходимость проведения дальнейших экспериментальных и клинических исследований при лечении данной патологии.

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