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Лиганды RAGE-белков: роль в межклеточной коммуникации и патогенезе воспаления

https://doi.org/10.15690/vramn566

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Аннотация

В обзоре литературы обсуждается разнообразие эндогенных лигандов RAGE-рецепторов, играющих важную роль в сигнальной трансдукции в физиологических условиях и при патологии. RAGE-рецепторы опосредуют многие физиологические функции, такие как рост клеток, апоптоз, выживание и регенерация; участвуют в воспалительных реакциях, индуцируя секрецию цитокинов и хемокинов; способствуют элиминации апоптотических клеток, являются участниками врожденного иммунного ответа. Рассмотрены механизмы образования растворимых форм RAGE, а также роль мембранной и растворимой форм рецепторов в передаче сигнальной информации при активации клеток. Признанными лигандами RAGE являются продукты неферментативного гликирования белков, бета-амилоид, ядерные белки HMGB1, кальцийсвязывающие белки S100A4, S100A8/A9, S100A12 и S100B. В статье обсуждаются механизмы продукции лигандов RAGE, секреции их из клеток различной природы, их взаимодействие с рецепторами и последствия этого взаимодействия для клеток и тканей. Особое внимание уделено анализу роли лигандов RAGE в развитии воспаления, в частности при повреждении головного мозга и нейродегенерации.

Об авторах

Юлия Александровна Успенская
ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России
Россия
доктор биологических наук, научный сотрудник НИИ молекулярной медицины и патобиохимии


Юлия Константиновна Комлева
ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России
Россия
кандидат медицинских наук, доцент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии, научный сотрудник НИИ молекулярной медицины и патобиохимии


Елена Анатольевна Пожиленкова
ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России
Россия
кандидат биологических наук, доцент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии, исполнительный директор НИИ молекулярной медицины и патобиохимии


Владимир Валерьевич Салмин
ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России
Россия
доктор физико-математических наук, зав. кафедрой медицинской и биологической физики


Ольга Леонидовна Лопатина
ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России
Россия
кандидат биологических наук, доцент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии, научный сотрудник НИИ молекулярной медицины и патобиохимии


Александр Анатольевич Фурсов
ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России
Россия
кандидат медицинских наук, ассистент кафедры анестезиологии и реаниматологии Института последипломного образования


Павел Вячеславович Лаврентьев
ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России
Россия
преподаватель кафедры медицинской и биологической физики, научный сотрудник НИИ молекулярной медицины и патобиохимии


Ольга Анатольевна Белова
ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России
Россия
ассистент кафедры травматологии, ортопедии и ВПХ с курсом ПО им. проф. Л.Л. Роднянского


Алла Борисовна Салмина
ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России
Россия
доктор медицинских наук, профессор, зав. кафедрой биохимии с курсами медицинской, фармацевтической и токсикологической химии, руководитель НИИ молекулярной медицины и патобиохимии


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Для цитирования:


Успенская Ю.А., Комлева Ю.К., Пожиленкова Е.А., Салмин В.В., Лопатина О.Л., Фурсов А.А., Лаврентьев П.В., Белова О.А., Салмина А.Б. Лиганды RAGE-белков: роль в межклеточной коммуникации и патогенезе воспаления. Вестник Российской академии медицинских наук. 2015;70(6):694-703. https://doi.org/10.15690/vramn566

For citation:


Uspenskaya Y.A., Komleva Y.K., Pozhilenkova E.A., Salmin V.V., Lopatina O.L., Fursov A.A., Lavrent'ev P.V., Belova O.A., Salmina A.B. Ligands of RAGE-Proteins: Role in Intercellular Communication and Pathogenesis of Inflammation. Annals of the Russian academy of medical sciences. 2015;70(6):694-703. (In Russ.) https://doi.org/10.15690/vramn566

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