Лиганды RAGE-белков: роль в межклеточной коммуникации и патогенезе воспаления

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В обзоре литературы обсуждается разнообразие эндогенных лигандов RAGE-рецепторов, играющих важную роль в сигнальной трансдукции в физиологических условиях и при патологии. RAGE-рецепторы опосредуют многие физиологические функции, такие как рост клеток, апоптоз, выживание и регенерация; участвуют в воспалительных реакциях, индуцируя секрецию цитокинов и хемокинов; способствуют элиминации апоптотических клеток, являются участниками врожденного иммунного ответа. Рассмотрены механизмы образования растворимых форм RAGE, а также роль мембранной и растворимой форм рецепторов в передаче сигнальной информации при активации клеток. Признанными лигандами RAGE являются продукты неферментативного гликирования белков, бета-амилоид, ядерные белки HMGB1, кальцийсвязывающие белки S100A4, S100A8/A9, S100A12 и S100B. В статье обсуждаются механизмы продукции лигандов RAGE, секреции их из клеток различной природы, их взаимодействие с рецепторами и последствия этого взаимодействия для клеток и тканей. Особое внимание уделено анализу роли лигандов RAGE в развитии воспаления, в частности при повреждении головного мозга и нейродегенерации.

Об авторах

Юлия Александровна Успенская

ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России

Автор, ответственный за переписку.
Email: uspenskaya.yulia@gmail.com
доктор биологических наук, научный сотрудник НИИ молекулярной медицины и патобиохимии Россия

Юлия Константиновна Комлева

ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России

Email: yuliakomleva@mail.ru
кандидат медицинских наук, доцент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии, научный сотрудник НИИ молекулярной медицины и патобиохимии Россия

Елена Анатольевна Пожиленкова

ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России

Email: Elena.a.pozhilenkova@gmail.com
кандидат биологических наук, доцент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии, исполнительный директор НИИ молекулярной медицины и патобиохимии Россия

Владимир Валерьевич Салмин

ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России

Email: vsalmin@gmail.com
доктор физико-математических наук, зав. кафедрой медицинской и биологической физики Россия

Ольга Леонидовна Лопатина

ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России

Email: ol.lopatina@gmail.com
кандидат биологических наук, доцент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии, научный сотрудник НИИ молекулярной медицины и патобиохимии Россия

Александр Анатольевич Фурсов

ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России

Email: fursov_alex@mail.ru
кандидат медицинских наук, ассистент кафедры анестезиологии и реаниматологии Института последипломного образования Россия

Павел Вячеславович Лаврентьев

ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России

Email: lavran@inbox.ru
преподаватель кафедры медицинской и биологической физики, научный сотрудник НИИ молекулярной медицины и патобиохимии Россия

Ольга Анатольевна Белова

ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России

Email: ulyabelova@mail.ru
ассистент кафедры травматологии, ортопедии и ВПХ с курсом ПО им. проф. Л.Л. Роднянского Россия

Алла Борисовна Салмина

ГБОУ ВПО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава России

Email: allasalmina@mail.ru
доктор медицинских наук, профессор, зав. кафедрой биохимии с курсами медицинской, фармацевтической и токсикологической химии, руководитель НИИ молекулярной медицины и патобиохимии Россия

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