Algorithm of Macrophage Activation Assessment for Forecasting and Evaluation of Treatment Effectiveness of Human Diseases

Cover Page


Cite item

Full Text

Abstract

Despite the high complexity of macrophage activation and subsequent polarization, determination of the key dynamic features of these processes provides the basis for both assessment of macrophage activation current state and for disease prognosis. To sum it up either macrophage phenotype ratio or polarizing stimulus ratio may be the most important indicators.

About the authors

V. N. Sakharov

Sechenov First Moscow State Medical University

Author for correspondence.
Email: vladimirsah91@mail.ru
Moscow Россия

P. F. Litvitskiy

Sechenov First Moscow State Medical University

Email: litvicki@mma.ru
Moscow Россия

References

  1. Martinez F. O., Gordon. S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000 Prime Rep. 2014; 6: 13. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944738/ (accessed: 05.04.2014).
  2. Ka M.B., Daumas A., Textoris J., Mege J.L. Phenotypic diversity and emerging new tools to study macrophage activation in bacterial infectious disease. Front. Immunol. 2014; 5: 500. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193331 (accessed: 07.12.2014).
  3. Sica A., Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J. Clin. Invest. 2012; 122 (3): 787–795. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287223/ (accessed: 26.11.2014).
  4. Wang Y., Yang T., Ma Y., Halade G.V., Zhang J., Lindsey M.L., Jin Y.F. Mathematical modeling and stability analysis of macrophage activation in left ventricular remodeling postmyocardial infarction. BMC Genomics. 2012; 13 (Suppl. 6): 21. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481436/ (accessed: 11.10.2014).
  5. Hashimoto D., Chow A., Noizat C., Teo P., Beasley M.B., Leboeuf M., Becker C.D., See P., Price J., Lucas D., Greter M., Mortha A., Boyer S.W., Forsberg E.C., Tanaka M., van Rooijen N., García-Sastre A., Stanley E.R., Ginhoux F., Frenette P.S., Merad M. Tissue resident macrophages self maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity. 2013; 38 (4): 792–804. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853406 (accessed: 11.10.2014).
  6. Van Dyken S.J., Locksley R.M. Interleukin-4 and intrerleukin-13 mediated alternatively activated macrophages: roles in homeostasis and disease. Ann. Rev. Immunol. 2013; 31: 317–343. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606684/ (accessed: 15.04.2014).
  7. Murray P.J., Wynn T.A. Protective and pathogenic functions of macrophage subsets. Nat. Rev. Immunol. 2011; 11 (11): 723–737. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422549/ (accessed: 15.04.2014).
  8. Day N.P., Hien T.T., Schollaardt T., Loc P.P., Chuong L.V., Chau T.T., Mai N.T., Phu N.H., Sinh D.X., White N.J., Ho M. The prognostic and pathophysiologic role of pro- and antiinflammatory cytokines in severe malaria. J. Infect. Dis. 1999; 180 (4): 1288–1297. Available at: http://m.jid.oxfordjournals.org/content/180/4/1288.full.pdf (accessed: 15.01.2014).
  9. Gogos C.A., Drosou E., Bassaris H.P., Skoutelis A. Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. J. Infect. Dis. 2000; 181 (1): 176–180. Available at: http://m.jid.oxfordjournals.org/ontent/181/1/176.full.pdf (accessed: 15.01.2014).
  10. Marino S., Cilfone N.A., Mattila J.T., Linderman J.J., Flynn J.L., Kirschner D.E. Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection. Infect. Immun. 2015; 83 (1): 324–338. Available at: http://www.ncbi.nlm.nih. gov/pubmed/25368116 (accessed: 16.01.2015).
  11. Miettinen K.H., Lassus J., Harjola V.P., Siirilä-Waris K., Melin J., Punnonen K.R., Nieminen M.S., Laakso M., Peuhkurinen K.J. Prognostic role of pro- and anti-inflammatory cytokines and their polymorphisms in acute decompensated heart failure. Eur. J. Heart Fail. 2008; 10 (4): 396–403. Available at: http://onlinelibrary.wiley.com/doi/10.1016/j.ejheart.2008.02.008/pdf (accessed: 15.01.2014).
  12. Ohtsuka T., Hamada M., Inoue K., Ohshima K., Sujzuki J., Matsunaka T., Ogimoto A., Hara Y., Shigematsu Y., Higaki J. Relation of circulating interleukin-6 to left ventricular remodeling in patients with reperfused anterior myocardial infarction. Clin. Cardiol. 2004; 27 (7): 417–420. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15298045 (accessed: 16.01.2014).
  13. Csontos C., Foldi V., Pálinkas L., Bogar L., Röth E., Weber G., Lantos J. Time course of pro- and anti-inflammatory cytokine levels in patients with burns prognostic value of interleukin-10. Burns. 2010; 36 (4): 483–494. Available at: http://www.sciencedirect.com/science/article/pii/S030541790900518X (accessed: 16.01.2014).
  14. Cornelissen R., Lievense L.A., Maat A.P., Hendriks R.W., Hoogsteden H.C., Bogers A.J., Hegmans J.P., Aerts J.G. Ratio of intratumoral macrophage phenotypes is a prognostic factor in epithelioid malignant pleural mesothelioma. PLoS One. 2014; 9 (9): e106742. Available at: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106742 (accessed: 16.01.2015).
  15. Ren F., Fan M., Mei J., Wu Y., Liu C., Pu Q., You Z., Liu L. Interferon-γ and celecoxib inhibit lung tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment. Drug Des. Devel. Ther. 2014; 8: 1527–1538. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25284985/ (accessed: 16.10.2014).
  16. Na Y.R., Yoon Y.N., Son D.I., Seok S.H. Cyclooxygenase-2 inhibition blocks M2 macrophage differentiation and suppresses metastasis in murine breast cancer model. PLoS One. 2013; 8 (5): e63451. Available at: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0063451 (accessed: 11.10.2014).

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2015 "Paediatrician" Publishers LLC



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies