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The Effect of the Antioxidant Drug U-74389G on Magnesium Levels During Hypoxia–Reoxygenation Injury in Rats
- Authors: Τsompos C.1, Panoulis C.2, Τοutouzas K.2, Ζografos G.2, Papalois A.3
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Affiliations:
- Mesologi County Hospital
- Aretaieion Hospital, Athens University
- Exprerimental Research Center ELPEN Pharmaceuticals, S.A. Inc., Co.
- Issue: Vol 70, No 4 (2015)
- Pages: 408-412
- Section: PHYSIOLOGY: CURRENT ISSUES
- Published: 28.09.2015
- URL: https://vestnikramn.spr-journal.ru/jour/article/view/487
- DOI: https://doi.org/10.15690/vramn.v70.i4.1405
- ID: 487
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Abstract
Objective: The aim of this experimental study was to examine the effect of the antioxidant drug U-74389G in a rat model of hypoxia – reoxygenation using the previously established protocol. Effects of treatments were evaluated by magnesium (Mg2+) levels in blood.
Methods: Nonrandomized controlled study was performed. Mg2+ levels were determined in 60 min (groups A and C) and 120 min (groups B and D) after starting the reoxygenation. Groups A and B received no drugs, whereas rats from groups C and D were administered with U-74389G.
Results: 40 rats 16–18 weeks old of a mean weight of 2312 g were employed in the study. It is demonstrated that U-74389G administration did not alter the Mg2+ levels (decrease in Mg2+ concentration was 0.28±2.75%; p =0.917). Reoxygenation non-significantly increased the Mg2+ levels by 4.27±2.66% (p =0.107). Together, the U-74389G administration and reoxygenation non-significantly increased the Mg2+ levels by 0.36±1.64% (p =0.823).
Conclusion: U-74389G administration, alone or in concert with reoxygenation did not significantly affect Mg2+ level in blood after experimental hypoxia in rats.
Keywords
About the authors
C. Τsompos
Mesologi County Hospital
Author for correspondence.
Email: Constantinostsompos@yahoo.com
Etoloakarnania
ГрецияC. Panoulis
Aretaieion Hospital, Athens University
Email: Kwn.panoulis@gmail.com
Attiki
ГрецияK. Τοutouzas
Aretaieion Hospital, Athens University
Email: Tousur@hotmail.com
Attiki
ГрецияG. Ζografos
Aretaieion Hospital, Athens University
Email: Gzografo@med.uoa.gr
Attiki
ГрецияA. Papalois
Exprerimental Research Center ELPEN Pharmaceuticals, S.A. Inc., Co.
Email: Apapalois@elpen.gr
директор,
95 Marathonos Avenue, Пикерми, 19009, Аттика
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