The Effect of the Antioxidant Drug U-74389G on Magnesium Levels During Hypoxia–Reoxygenation Injury in Rats

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Abstract

Objective: The aim of this experimental study was to examine the effect of the antioxidant drug U-74389G in a rat model of hypoxia – reoxygenation using the previously established protocol. Effects of treatments were evaluated by magnesium (Mg2+) levels in blood.

Methods: Nonrandomized controlled study was performed. Mg2+ levels were determined in 60 min (groups A and C) and 120 min (groups B and D) after starting the reoxygenation. Groups A and B received no drugs, whereas rats from groups C and D were administered with U-74389G.

Results: 40 rats 16–18 weeks old of a mean weight of 2312 g were employed in the study. It is demonstrated that U-74389G administration did not alter the Mg2+ levels (decrease in Mg2+ concentration was 0.28±2.75%; p =0.917). Reoxygenation non-significantly increased the Mg2+ levels by 4.27±2.66% (p =0.107). Together, the U-74389G administration and reoxygenation non-significantly increased the Mg2+ levels by 0.36±1.64% (p =0.823).

Conclusion: U-74389G administration, alone or in concert with reoxygenation did not significantly affect Mg2+ level in blood after experimental hypoxia in rats.

About the authors

C. Τsompos

Mesologi County Hospital

Author for correspondence.
Email: Constantinostsompos@yahoo.com

Etoloakarnania

Greece

C. Panoulis

Aretaieion Hospital, Athens University

Email: Kwn.panoulis@gmail.com

Attiki

Greece

K. Τοutouzas

Aretaieion Hospital, Athens University

Email: Tousur@hotmail.com

Attiki

Greece

G. Ζografos

Aretaieion Hospital, Athens University

Email: Gzografo@med.uoa.gr

Attiki

Greece

A. Papalois

Exprerimental Research Center ELPEN Pharmaceuticals, S.A. Inc., Co.

Email: Apapalois@elpen.gr

директор,

95 Marathonos Avenue, Пикерми, 19009, Аттика

Greece

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