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Depression is considered to be an independent cardiovascular risk factor and it may worsen the symptoms of already established cardiovascular pathology such as coronary heart disease, chronic heart failure, stroke and hypertension. 3 key psychobiological mechanisms by means of which depression influences cardiovascular system: disbalance in stress response of endocrine system, hyperregulation of autonomic nervous system and immune disorders leading to dysregulation of acute phase proteins and proinflammatory cytokines release. In majority of studies in patients with depression and cardiovascular diseases it was shown that antidepressants improve the symptoms. By the way, in some studies controversial results were obtained. Future studies in this direction with involvement of cardiologists and psychiatrists should be held.


About the authors

N. F. Nuralieva

I.M. Sechenov First Moscow State Medical University, Russian Federation

Author for correspondence.
undergraduate of Faculty of general medicine of I.M. Sechenov First Moscow State Medical University Address: bld. 2, 8, Trubetskaya Street, Moscow, 119992, tel.: +7 (495) 609-14-00 Russian Federation

D. A. Napalkov

I.M. Sechenov First Moscow State Medical University, Russian Federation


PhD, professor of the Intermediate Level Therapy Department of №1 of Faculty of general medicine of I.M. Sechenov First Moscow State Medical University, Head of the Therapy School of I.M. Sechenov First MSMU Address: bld. 2, 8, Trubetskaya Street, Moscow, 119992, tel.: +7 (495) 609-14-00

Russian Federation


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