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CHILD AND ADOLESCENT INTEREPYDEMIC IMMUNITY TO INFLUENZA VIRUSES
- Authors: Lyapunov A.V.1, Kolesnikova S.I.1, Khasnatinov M.A.1, Manzarova E.L.1, Petrova I.V.1, Dolgikh V.V.1, Danchinova G.A.1
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Affiliations:
- Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russian Federation
- Issue: Vol 70, No 3 (2015)
- Pages: 315–319
- Section: PEDIATRICS: CURRENT ISSUES
- URL: https://vestnikramn.spr-journal.ru/jour/article/view/36
- DOI: https://doi.org/10.15690/vramn.v70i3.1327
- ID: 36
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Abstract
Objective: Our aim was to evaluate the child and adolescent population immunity to influenza A viruses (IAV) and influenza B virus (IBV). Methods: The concentration and specificity of antiviral antibodies was evaluated by hemagglutination inhibition assay (HAI) that was performed using commercial HAI diagnostic kits. Results: The serum samples of 254 clinically healthy children and adolescents were examined in this study. 245 participants had the antibodies to IAV, 199 — to IAV and IBV, and only 4 children aged between 1 and 4 years and a 12-year-old boy had no immunity to IAV or IBV. The number of children with specific immunity increased in elder groups by 43% (from 81 to 116) for N0N1 and H3N2 subtypes and by 110% (from 38 to 80) for H1N1 subtype of IAV. In children younger than 4 years the titer of specific antibodies against the H1N1pdm09 was 1:210 and against the H3N2 — 1:270, whereas in adolescents of 10–14 years these figures were by 1.6 and 2.4 times lower (1:130 and 1:120) respectively. Antibodies to the subtypes H2N2 and H5N1 were not detected. Conclusion: The results indicate that 98.4% of child and adolescent population in interepidemic influenza season are immune to the various IAV (H3N2, H1N1, H0N1) as well as to the IBV. More than half of children and adolescents (57.4%) are immune to H1N1pdm09 subtype of IAV. The strength of immune response to the recent pathogens (H3N2 и H1N1 pdm09) is higher in infants than in teenagers.
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About the authors
A. V. Lyapunov
Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russian Federation
Author for correspondence.
Email: liapunov.asp@mail.ru
кандидат биологических наук, старший научный сотрудник лаборатории трансмис-
сивных инфекций НЦ ПЗСРЧ
Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 33-39-71
S. I. Kolesnikova
Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russian Federation
Email: sikolesnikov2012@gmail.com
доктор медицинских наук, академик РАН, советник РАН, заслуженный деятель науки РФ
Адрес: 109240, Москва, ул. Солянка, д. 14 , тел.: +7 (495) 69-85-816
M. A. Khasnatinov
Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russian Federation
Email: khasnatinov@yandex.ru
кандидат биологических наук, ведущий научный сотрудник лаборатории транс-
миссивных инфекций НЦ ПЗСРЧ
Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 33-39-71
E. L. Manzarova
Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russian Federation
Email: manzarova89@yandex.ru
младший научный сотрудник лаборатории трансмиссивных инфекций НЦ ПЗСРЧ
Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 33-39-71
I. V. Petrova
Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russian Federation
Email: irina_petrova_62@list.ru
врач высшей категории, руководитель отделения аллергологии Клиники НЦ ПЗСРЧ
Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 33-34-45
V. V. Dolgikh
Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russian Federation
Email: dolgikh64@gmail.com
доктор медицинских наук, профессор, заместитель директора по научной работе
НЦ ПЗСРЧ
Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 20-76-36
G. A. Danchinova
Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russian Federation
Email: dan-chin@yandex.ru
доктор биологических наук, руководитель лаборатории трансмиссивных инфекций
НЦ ПЗСРЧ
Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 33-39 71
References
- Bouvier N.M., Palese P. The Biology Of Influenza Viruses. Vaccine. 2008; 26 (Suppl. 4.): 49–53.
- Chebotareva T.A., Malinovskaya V.V., Mazankova L.N., Karyaeva S.K., Parshina O.V., Guseva T.S., Lazarev V.V., Kaloeva Z.D. RRI children: immunological concept of prevention of influenza and other acute respiratory viral infections. Pediatr = Pediatrician. 2010;1(2):106–110.
- Baranov A.A., Namazova-Baranova L.S., Il'in A.G. The preservation and strengthening of health of adolescents - a pledge of stable development of society and the state (state of the problem). Vestnik RAMN = Annals of RAMS. 2014;5–6:65–70.
- Prokopeva E.A., Sayfutdinova S.G., Glushchenko A.V., Kurskaya O.G., Zaykovskaya A.V., Durymanov A.G., Ilyicheva T.N.,
- Shestopalova L.V., Shestopalov A.M. Comparative Analysis of Biological Propertis of Influenza A(H1N1) pdm09 Virus Strains isolated in the Pandemic of 2009 and the Post Pandemic Period in the Asian Part of Russia. J. Virol. Microbiol. 2013; 2013: 890660.
- Kurskaya O.G., Sobolev I.A., Durymanov A.G., Dronova S.A., Shestopalov A.M., Il'icheva T.N. Analysis of the epidemic situation of influenza in 2011-2012 in Western Siberia. Vestnik NGU = Bulletin of NSU. 2013;11(1):118–123.
- Danchinova G.A., Lyapunov A.V., Petrova I.V., Glushenkova T.V., Chaporgina E.A., Arbatskaya E.V., Rykova E.V., Savel'kaeva M.V., Mironova L.V., Dolgikh V.V. Information system "Patients who have undergone a tick bite, and the results of laboratory studies of blood serum" (ASC "Antibodies"). Elektronnyi byulleten' = Electronic bulletin. 2009;1:414.
- Lyapunov A.V. Danchinova G.A., Arbatskaya E.V., Chaporgina E.A., Tunik T.V., Khasnatinov M.A., Petrova I.V. Information-analytical system "Monitoring of influenza viruses A and B interepidemic season" (IAS "Flu-antibody"). Elektronnyi byulleten' = Electronic bulletin. 2013;2:.
- Gol'dshtein A.V. Semenov B.F. Problem of "bird flu" and influenza pandemic in the human population (based on the WHO). Remedium = Remedium. 2005;3:40–43.
- Reconsideration of influenza A virus nomenclature: a WHO memorandum. Bull. World Health Organ. 1979; 57: 227–233.
- Brugh M., Jr. Asimplemethod for recording and analyzing serological data. Avian Dis. 1978; 22 (2): 362–365.
- Chaporgina E.A. Lyapunov A.V., Arbatskaya E.V. Khasnatinov M.A., Petrova I.V., Danchinova G.A., Mironova T.V., Yakovchits N.V. Sero-epidemiological survey of the residents of Irkutsk for the presence of antibodies to the flu virus. Byulleten' VSNTs SO RAMN = Bulletin ESSC SD RAMS. 2011;1(1):173–176.
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