HYPERGLYCEMIA IMPACT ON ANGIOGENIC PROPERTIES OF ENDOTHELIAL AND PROGENITOR VASCULAR CELLS

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Abstract

This report contains authors own data about hyperglycemia impact on main functional properties of endothelial cells, mesenchymal stem cells and
circulating progenitor cells, which define their participation in angiogenesis. Obtained data shows that cultivation of endothelial cells in hyperglycemic
conditions leads to decrease of their ability for targeted migration and vascular-like structures formation on matrigel, and to suppression of VEGF
receptors expression in these cells. Mesenchymal stem cells cultivated in hyperglycemic conditions have altered expression profile, decreased ability
to stimulate angiogenesis via paracrine activity. Hyperglycemia in CHD patients with concomitant diabetes mellitus type II most probably lead to
circulating bone marrow progenitor cells mobilisation distortion in response to tissue ischemia and damage to the endothelium, that can infringe upon
their participation in endothelium reparation and angio- and vasculogenesis in the ischemic conditions. Found distortions can be used as targets for the treatment aimed at cardiovascular complications prevention in diabetic patients.

About the authors

Е. V. Parfenova

FSBI Russian cardiologic scientific productive complex Ministry of Healthcare
and Social development of Russian Federation, Moscow

Author for correspondence.
Email: yeparfyon@mail.ru
доктор медицинских наук, профессор, руководитель лаборатории ангиогенеза ФГБУ «Российский кардиологический научно-производственный комплекс» Минздравсоцразвития России Адрес: 121552, Москва, ул. 3-я Черепковская, 15-а Тел.: +7(495)414-67-12 Россия

V. A. Tkachuk

Lomonosov Moscow State University

Email: tkachuk@fbm.msu.ru
доктор биологических наук, профессор, академик РАН и РАМН, декан ГУНУ факуль- тета фундаментальной медицины Московского государственного университета им. М.В. Ломоносова Адрес: 119192, Москва, Ломоносовский пр., 31, корп. 5 Тел.: +7(495)932-88-14 Россия

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