Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciences0869-60472414-3545"Paediatrician" Publishers LLC35410.15690/vramn.v67i1.108HYPERGLYCEMIA IMPACT ON ANGIOGENIC PROPERTIES OF ENDOTHELIAL AND PROGENITOR VASCULAR CELLSParfenovaЕ. V.yeparfyon@mail.ruTkachukV. A.tkachuk@fbm.msu.ruFSBI Russian cardiologic scientific productive complex Ministry of Healthcare
and Social development of Russian Federation, MoscowLomonosov Moscow State University22012012671384407082015Copyright © 2012, "Paediatrician" Publishers LLC2012<em>This report contains authors own data about hyperglycemia impact on main functional properties of endothelial cells, mesenchymal stem cells and</em><br /><em>circulating progenitor cells, which define their participation in angiogenesis. Obtained data shows that cultivation of endothelial cells in hyperglycemic</em><br /><em>conditions leads to decrease of their ability for targeted migration and vascular-like structures formation on matrigel, and to suppression of VEGF</em><br /><em>receptors expression in these cells. Mesenchymal stem cells cultivated in hyperglycemic conditions have altered expression profile, decreased ability</em><br /><em>to stimulate angiogenesis via paracrine activity. Hyperglycemia in CHD patients with concomitant diabetes mellitus type II most probably lead to</em><br /><em>circulating bone marrow progenitor cells mobilisation distortion in response to tissue ischemia and damage to the endothelium, that can infringe upon</em><br /><em>their participation in endothelium reparation and angio- and vasculogenesis in the ischemic conditions. Found distortions can be used as targets for</em><em> the treatment aimed at cardiovascular complications prevention in diabetic patients.</em><br /><br />hyperglycemiadiabetes mellitus type IIangiogenesisгипергликемиясахарный диабет 2 типаангиогенез