THE STRUCTURE OF LIVER, LUNG, KIDNEYS, HEART AND SPLEEN OF RATS AFTER REPEATED INTRAVENOUS APPLICATION OF NANOPARTICLES MAGNETITE

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Abstract


Effects of multiple intravenous magnetite nanosuspension injections on the structure of rat liver, lungs, kidney, heart and spleen have been studied. Histology of the organs listed have found haemodynamic distortions and necrotic lesions in the parenchyma of these organs. With the help of Pearls histochemical method significant piling of nanoparticles were found in the cells of the mononuclear phagocytes in liver, lungs and spleen of the rats. Only singular Pearls-positive cells were found in kidneys and hearts of the rats.


I. V. Mil'to

Siberian State Medical University
National Research Tomsk Polytechnic University

Author for correspondence.
Email: milto_bio@mail.ru

Russian Federation кандидат биологических наук, ассистент кафедры биотехнологии и органической химии ФГБОУ ВПО НИ ТПУ, руководитель научно-образовательного центра «Инновационные технологии в морфологии» Сибирского государственного медицинского университета Минздравсоцразвития России Адрес: 636036, Северск, ул. Крупской, д. 10, кв. 15 Тел.: 8 (3822) 42-64-43

I. V. Sukhodolo

National Research Tomsk Polytechnic University

Email: suhodolo@sibmail.com

Russian Federation доктор медицинских наук, профессор, заведующая кафедрой морфологии и общей патологии Сибирского государственного медицинского университета Минздравсоцразвития России Адрес: 634003, Томск, пер. Кустарный, д. 1, кв. 11 Тел.: 8 (3822) 42-64-43

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