AGONIST OF V2 VASOPRESSIN RECEPTOR REDUCES DEPRESSIVE DISORDERS IN POST-STROKE PATIENTS

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Abstract


Poststroke depression is one of the common psychiatric complications after stroke. Thus, the research of new ways for treatment depressed mood after stroke is actual. The previous researches revealed vasopressin to be effective in patients with memory, speech and motor function disorders after stroke. The purpose of the study was to investigate influence of vasopressin on depression after stroke. Fourteen patients with affective disorders have been treated with subendocrine doses of 1-desamino-8-D-arginin-vasopressin (DDAVP) daily by intranasal application during 1,5–2 months. Vasopressin was effective in correcting both apatoadinamic and anxious depression. Treatment effect was durable, lasts for 0,5–1 year after the first course of therapy. The results of this pilot study demonstrate perspective of using selective agonist of vasopressin V2 receptors, DDAVP, in therapy of post-stroke depression.

 


S. G. Belokoskova

Institute of Experimental Medicine NWB RAMS

Author for correspondence.
Email: sgb@nm.ru

Russian Federation кандидат медицинских наук, научный сотрудник лаборатории психофизиологии эмоций физиологического отдела им. И.П. Павлова ФГБУ «Научно-исследовательский институт эксперимен- тальной медицины» Северо-Западного отделения РАМН Адрес: 197376, Санкт-Петербург, ул. Акад. Павлова, д. 12 Тел.: (812) 234-27-35

I. I. Stepanov

Institute of Experimental Medicine NWB RAMS

Email: igorstep@isl2044.spb.edu

Russian Federation доктор медицинских наук, ведущий научный сотрудник лаборатории химии и фармако- логии лекарственных средств отдела нейрофармакологии ФГБУ «Научно-исследовательский институт эксперимен- тальной медицины» Северо-Западного отделения РАМН Адрес: 197376, Санкт-Петербург, ул. Акад. Павлова, д. 12 Тел.: (812) 234-54-47

S. G. Tsikunov

Institute of Experimental Medicine NWB RAMS

Email: secikunov@yandex.ru

Russian Federation доктор медицинских наук, профессор, заведующий лабораторией психофизиологии эмоций физиологического отдела им. И.П. Павлова ФГБУ «Научно-исследовательский институт эксперимен- тальной медицины» Северо-Западного отделения РАМН Адрес: 197376, Санкт-Петербург, ул. Акад. Павлова, д. 12 Тел.: (812) 234-27-35

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