ROLE OF DOPAMINE D1- AND D2-RECEPTORS IN THE DELTA1-OPIOIDERGIC IMMUNOSTIMULATION

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Abstract


The study has shown that activation of delta1-opioid receptors by a highly selective peptide agonist DPDPE (100 µg/kg) results in a significant increase of the immune response to antigen (SRBC, 5×108) in CBA mice. SCH-23390 (1 mg/kg), a selective antagonist of the postsynaptic dopamine D1-receptors, and selective D2-blocker haloperidol (1 mg/kg) prevented immunostimulating effect of DPDPE. Comparison of effects of the antagonists suggests that delta1-opioidergic immunostimulation has more significant impact due to involvement of dopamine D1-receptors.

 


About the authors

M. A. Cheido

Federal State Budgetary Institution «Research Institute of Physiology» under the Siberian Branch of the Russian Academy
of Medical Sciences , Novosibirsk

Author for correspondence.
Email: cheido@physiol.ru

Russian Federation кандидат биологических наук, ведущий научный сотрудник лаборатории меха- низмов нейрохимической модуляции ФГБУ «Научно-исследовательский институт физиологии» Сибирского отде- ления РАМН Адрес: 630117, Новосибирск, ул. Академика Тимакова, д. 4 Тел.: (383) 335-98-58 Факс: (383) 335-98-54

M. M. Gevorkyan

Federal State Budgetary Institution «Research Institute of Physiology» under the Siberian Branch of the Russian Academy
of Medical Sciences , Novosibirsk

Email: gevorgyanmm@ngs.ru

Russian Federation кандидат биологических наук, ведущий научный сотрудник лаборатории меха- низмов нейрохимической модуляции ФГБУ «Научно-исследовательский институт физиологии» Сибирского отде- ления РАМН Адрес: 630117, Новосибирск, ул. Академика Тимакова, д. 4 Тел.: (383) 335-98-58 Факс: (383)335-98-54

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