Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciences0869-60472414-3545"Paediatrician" Publishers LLC30510.15690/vramn.v67i5.275ROLE OF DOPAMINE D1- AND D2-RECEPTORS IN THE DELTA1-OPIOIDERGIC IMMUNOSTIMULATIONCheidoM. A.cheido@physiol.ruGevorkyanM. M.gevorgyanmm@ngs.ruFederal State Budgetary Institution «Research Institute of Physiology» under the Siberian Branch of the Russian Academy
of Medical Sciences , Novosibirsk23052012675555707082015Copyright © 2012, "Paediatrician" Publishers LLC2012<p class="Text05"><em>The study has shown that activation of delta<sub>1</sub>-opioid receptors by a highly selective peptide agonist DPDPE (100 µg/kg) results in a significant increase of the immune response to antigen (SRBC, 5×10<sup>8</sup>) in CBA mice. SCH-23390 (1 mg/kg), a selective antagonist of the postsynaptic dopamine D<sub>1</sub>-receptors, and selective D<sub>2</sub>-blocker haloperidol (1 mg/kg) prevented immunostimulating effect of DPDPE. </em><em>Comparison of effects of the antagonists suggests that delta<sub>1</sub>-opioidergic immunostimulation has more significant impact due to involvement of dopamine D<sub>1</sub>-receptors.</em></p><p class="Text05"> </p>delta1-opioid receptorsDPDPE, D1-, D2-dopamine receptorsIgM-immune responseдельта1-опиоидные рецепторыDPDPED1-, D2-дофаминовые рецепторыIgM-иммунный ответ[1. Coop A., Rice K.C. Role of w-opioid receptors in biological processes. Drug News Perspect. 2000; 13 (13): 481–487.][2. Varona A., Gill J., Saracibar G. et al. Effects of imipramine treatment on delta-opioid receptors of the rat brain cortex and striatum. Arzneimittelforschung. 2003; 53 (1): 21–25.][3. Chei`do M.A., Idova G.V. Rol` serotoninovy`kh retceptorov v del`taopioidnoi` immunosupressii. Ros. fiziol. zhurn. im. I.M.Sechenova. 2010; 96 (2): 1234–1240.][4. Husted T.L., Govindaswami M., Oeltgen P.R. et al. A delta2-opioid agonist inhibits p38 MARK and suppresses activation of murine macrophages. J Surg Res. 2005; 128 (1): 45–49.][5. Rahim R.T., Meissier J.J., Cowan A. et al. Administration of mu-, kappa- or delta2-receptor agonists via osmotic minipumps suppresses murine splenic antibody responses. Int. Immunopharmacol. 2001; 1 (11): 2001–2009.][6. Smakhtin M.Y., Konoplya A.I., Sever’yanova L.A., Shveinov I.A. DSLET and ACTH(4-10) increase mitotic activity of hepatocytes and suppress antibody production. Bull Exp. Biol. Med. 2003; 135 (5): 428–429.][7. Kim K.W., Kim S.J., Shin B.S., Choi H.J. Ligand binding profiles of delta-opioid receptor in human cerebral cortex membranes: evidence of delta-opioid receptor heterogeneity. Life Sci. 2001; 68 (14): 1649–1656.][8. Cheido M.A., Idova G.V., Devoino L.V. Involvement of deltaopioid receptors in immunosuppression. Inter. J. Neurosci. 1996; 84: 195–203.][9. Devoino L., Cheido M., Alperina E., Idova G. Evidence for a role of dopaminergic mechanisms in the immunostimulating effect of µ-opioid receptor agonist DAGO. Intern. J. Neurosci. 2003; 113: 1381–1394.][10. Cunningham A.J. A method of increased sensitivity for detecting single antibody forming cells. Nature. 1965; 207: 1106– 1107.][11. Hiller J.M., Fan LQ., Simon E.J. Autoradiographic comparison of [3]DPDPE and [3]DSLET binding: evidence for distinct delta 1 and delta 2 opioid receptor populations in rat brain. Brain Res. 1996; 719 (1–2): 85–95.][12. Nistico G., Caroleo M.C., Arbitrio M., Pulvirenti L. Evidence for involvement of dopamine D1 receptors in the limbic system in the control of immune mechanisms. Neuroimmunomodulation. 1994; 1 (3): 174–180.][13. Devoi`no L.V., Al`perina E.L., Gevorgian M.M., Chei`do M.A. Uchastie v immunostimuliatcii dofaminovy`kh D1- i D2-retceptorov prilezhashchego iadra u qry`s. Ros. fiziol. zhurn. im. I.M.Sechenova. 2005; 91 (11): 1281–1287.][14. Hirose N., Murakawa K., Takada K. et al. Interactions aming mu- and delta-opioid receptors, especially putative delta1- and delta2- opioid receptors, promote dopamine release in the nucleus accumbens. Neuroscience. 2005; 135 (1): 213–225.][15. Chei`do M.A., Idova G.V. Differentcirovanny`i` vclad dofaminovy`kh D1- i D2-retceptorov v µ-opioidergichesquiu immunomoduliatciiu. Ros. fiziol. zhurn. im. I.M.Sechenova. 2006; 92 (5): 546–551.][16. Ambrose L.M., Gallagher S.M., Unterwald E.M., Van Bockstaele E.J. Dopamine D1 and delta-opioid receptors co-exist in rat striatal neurons. Neurosci. Lett. 2006; 399 (3): 191–196.]