TREATMENT OF HIV-INFECTION BY MEANS OF GENE THERAPY

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Abstract

Current methods of HIV treatment can contain a progression of the disease; however they do not lead to a cure. Lifelong antiretroviral therapy is therefore necessary, leading to problems of cost and toxicity of chemical drugs. The recent advances in science have allowed a new approach to the HIV-treatment — gene therapy. In the present publication we focus on one strategy of the gene therapy called «intracellular immunization». The strategy is based on the introducing of antiviral genes into the HIV-sensitive cells. We highlight the mechanisms of action of various antiviral genetic agents and discuss some issues concerning target cells and genes delivery. Finally we summarize the results of certain gene therapy clinical trials.

 

About the authors

D. V. Glazkova

Central Research Institute of Epidemiology, Russian Federal service on customers' rights protection and human well-being surveillance

Author for correspondence.
Email: glazkova@pcr.ru
кандидат биологических наук, научный сотрудник отдела молекулярной диагностики и эпидемиологии ФБУН ЦНИИ эпидемиологии Роспотребнадзора Адрес: 111123, Москва, ул. Новогиреевская, 3А Россия

E. V. Bogoslovskaya

Central Research Institute of Epidemiology, Russian Federal service on customers' rights protection and human well-being surveillance

Email: lenabo@pcr.ru
кандидат медицинских наук, старший научный сотрудник отдела молекулярной диагностики и эпидемиологии ФБУН ЦНИИ эпидемиологии Роспотребнадзора Адрес: 111123, Москва, ул. Новогиреевская, д. 3А E-mail: lenabo@pcr.ru Тел./ факс: (495) 305-54-23 Россия

M. L. Markelov

Research Institute of Occupational Health of Russian Academy of Medical Sciences

Email: markelov@pcr.ru
кандидат биологических наук, старший научный сотрудник лаборатории постге- номных технологий Института медицины труда РАМН Адрес: 105275, Москва, проспект Буденного, 31 Россия

G. A. Shipulin

Central Research Institute of Epidemiology, Russian Federal service on customers' rights protection and human well-being surveillance

Email: german@pcr.ru
кандидат медицинских наук, заведующий отделом молекулярной диагностики и эпидемиологии ФБУН ЦНИИ эпидемиологии Роспотребнадзора Адрес: 111123, Москва, ул. Новогиреевская, 3А Россия

V. V. Pokrovskii

Central Research Institute of Epidemiology, Russian Federal service on customers' rights protection and human well-being surveillance

Email: info@pcr.ru
академик РАМН, заместитель директора ФБУН ЦНИИ эпидемиологии Роспотребнадзора по научной работе Адрес: 111123, Москва, ул. Новогиреевская, 3А Тел.: (495) 974-96-46, факс: (495) 305-54-23 Россия

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