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Вестник Российской академии медицинских наук

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ЛЕЧЕНИЕ ВИЧ-ИНФЕКЦИИ С ПОМОЩЬЮ ГЕННОЙ ТЕРАПИИ

https://doi.org/10.15690/vramn.v67i5.268

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Аннотация

Современные методы лечения ВИЧ-инфекции позволяют сдерживать скорость развития заболевания, но не приводят к его излечению. Антиретровирусная терапия является пожизненной, дорогостоящей и сопровождается накоплением побочных эффектов. Последние достижения науки позволили предложить принципиально новый подход к лечению ВИЧ-инфекции — генную терапию. Настоящая публикация посвящена одному из направлений генной терапии ВИЧ, которое получило название «внутриклеточная иммунизация». В основе этого направления лежит идея введения антивирусных генов в чувствительные к ВИЧ клетки. В статье рассмотрены механизмы действия различных антивирусных генетических агентов, обсуждаются вопросы, связанные с выбором клеток-мишеней и способом доставки терапевтических генов. Представлены результаты клинических испытаний некоторых генотерапевтических препаратов для лечения ВИЧ-инфекции.

 

Об авторах

Д. В. Глазкова
ФГБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора, Москва
Россия
кандидат биологических наук, научный сотрудник отдела молекулярной диагностики и эпидемиологии ФБУН ЦНИИ эпидемиологии Роспотребнадзора Адрес: 111123, Москва, ул. Новогиреевская, 3А


Е. В. Богословская
ФГБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора, Москва
Россия
кандидат медицинских наук, старший научный сотрудник отдела молекулярной диагностики и эпидемиологии ФБУН ЦНИИ эпидемиологии Роспотребнадзора Адрес: 111123, Москва, ул. Новогиреевская, д. 3А E-mail: lenabo@pcr.ru Тел./ факс: (495) 305-54-23


М. Л. Маркелов
ФГБУ «Институт медицины труда» РАМН, Москва
Россия
кандидат биологических наук, старший научный сотрудник лаборатории постге- номных технологий Института медицины труда РАМН Адрес: 105275, Москва, проспект Буденного, 31


Г. А. Шипулин
ФГБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора, Москва
Россия
кандидат медицинских наук, заведующий отделом молекулярной диагностики и эпидемиологии ФБУН ЦНИИ эпидемиологии Роспотребнадзора Адрес: 111123, Москва, ул. Новогиреевская, 3А


В. В. Покровский
ФГБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора, Москва
Россия
академик РАМН, заместитель директора ФБУН ЦНИИ эпидемиологии Роспотребнадзора по научной работе Адрес: 111123, Москва, ул. Новогиреевская, 3А Тел.: (495) 974-96-46, факс: (495) 305-54-23


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Для цитирования:


Глазкова Д.В., Богословская Е.В., Маркелов М.Л., Шипулин Г.А., Покровский В.В. ЛЕЧЕНИЕ ВИЧ-ИНФЕКЦИИ С ПОМОЩЬЮ ГЕННОЙ ТЕРАПИИ. Вестник Российской академии медицинских наук. 2012;67(5):16-23. https://doi.org/10.15690/vramn.v67i5.268

For citation:


Glazkova D.V., Bogoslovskaya E.V., Markelov M.L., Shipulin G.A., Pokrovskii V.V. TREATMENT OF HIV-INFECTION BY MEANS OF GENE THERAPY. Annals of the Russian academy of medical sciences. 2012;67(5):16-23. (In Russ.) https://doi.org/10.15690/vramn.v67i5.268

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