MECHANISMS OF CEREBRAL DAMAGE IN PATIENTS WITH HIV-INFECTION

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  • Authors: Belyakov N.A.1, Medvedeva S.V.2, Trofimova T.N.1, Rassokhin V.V.1, Dement'eva N.E.3, Shelomov S.A.3
  • Affiliations:
    1. Institute of Experimental Medicine of the NorthWest Branch of the Russian Academy of Medical Sciences, St. Petersburg St. Petersburg Center for Control of AIDS and Infectious Diseases, Saint-Petersburg
    2. N.P. Bechterev Institute of Human Brain, St. Petersburg
    3. St. Petersburg Center for Control of AIDS and Infectious Diseases, Saint-Petersburg
  • Issue: Vol 67, No 9 (2012)
  • Pages: 4-12
  • Section: PROCEEDINGS OF THE RAMS SESSION
  • URL: https://vestnikramn.spr-journal.ru/jour/article/view/261
  • DOI: https://doi.org/10.15690/vramn.v67i9.400
  • Cite item

Abstract


Mechanisms of HIV transportation through blood-brain barrier, vascular plexus and interaction with cerebral cells having CD-4-receptors, ССR-5- and CXCR-4-coreceptors were studied. Cerebral damage developed through latent and acute periods also known as HIV-encephalopathy, HIV-associated neurocognitive dysfunction etc. Cerebral lesions are caused by a variety of chemical agents from pro-inflammatory cytokines to toxic HIV-proteins resulting in development of HIV-dementia through several years. Even early stage of this process revealed significant disturbances of glucose metabolism and evoked potentials EEG alterations which can serve as a marker of HIV-infection. Genetic differences of HIV in blood and spinal liquor with different drug resistance were revealed implying a new approach to therapy development.

 


About the authors

N. A. Belyakov

Institute of Experimental Medicine of the NorthWest Branch of the Russian Academy of Medical Sciences, St. Petersburg
St. Petersburg Center for Control of AIDS and Infectious Diseases, Saint-Petersburg

Author for correspondence.
Email: aidscentr@zdrav.spb.ru

Russian Federation доктор медицинских наук, академик РАМН, руководитель Санкт-Петербургского Центра по профилактике и борьбе со СПИД и инфекционными заболеваниями, главный научный сотрудник НИИ экспериментальной медицины СЗО РАМН Адрес: 190103, Санкт-Петербург, наб. Обводного канала, д. 179, лит. Б Тел.: (812) 251-08-53

S. V. Medvedeva

N.P. Bechterev Institute of Human Brain, St. Petersburg

Email: aidscentr@zdrav.spb.ru

Russian Federation доктор биологических наук, член-корреспондент РАН, директор Института мозга человека РАН, Санкт-Петербург Адрес: 193376, Санкт-Петербург, ул. Акад. Павлова, д. 9 Тел.: (812) 234-32-47

T. N. Trofimova

Institute of Experimental Medicine of the NorthWest Branch of the Russian Academy of Medical Sciences, St. Petersburg
St. Petersburg Center for Control of AIDS and Infectious Diseases, Saint-Petersburg

Email: Ras-doc@mail.ru

Russian Federation доктор медицинских наук, профессор, главный научный сотрудник Института мозга человека РАН, главный научный сотрудник НИИ экспериментальной медицины СЗО РАМН, профессор- консультант Санкт-Петербургского Центра по профилактике и борьбе со СПИД и инфекционными заболеваниями Адрес: 190103, Санкт-Петербург, наб. Обводного канала, д. 179, лит. Б Тел.: (812) 251-08-53

V. V. Rassokhin

Institute of Experimental Medicine of the NorthWest Branch of the Russian Academy of Medical Sciences, St. Petersburg
St. Petersburg Center for Control of AIDS and Infectious Diseases, Saint-Petersburg

Email: aidscentr@zdrav.spb.ru

Russian Federation кандидат медицинских наук, заместитель руководителя Санкт-Петербургского Центра по профилактике и борьбе со СПИД и инфекционными заболеваниями, ведущий научный сотрудник НИИ экспериментальной медицины СЗО РАМН Адрес: 190103, Санкт-Петербург, наб. Обводного канала, д. 179, лит. Б Тел.: (812) 251-08-53

N. E. Dement'eva

St. Petersburg Center for Control of AIDS and Infectious Diseases, Saint-Petersburg

Email: lab.dementeva@mail.ru

Russian Federation врач-генетик Санкт-Петербургского центра по профилактике и борьбе со СПИД и инфекционными заболеваниями, научный сотрудник НИИ экспериментальной медицины СЗО РАМН Адрес: 190103, Санкт-Петербург, наб. Обводного канала, д. 179, лит. Б Тел.: (812) 251-08-53

S. A. Shelomov

St. Petersburg Center for Control of AIDS and Infectious Diseases, Saint-Petersburg

Email: aidscentr@zdrav.spb.ru

Russian Federation врач-инфекционист Санкт-Петербургского Центра по профилактике и борьбе со СПИД и инфекционными заболеваниями Адрес: 190103, Санкт-Петербург, наб. Обводного канала, д. 179, лит. Б Тел.: (812) 251-0853

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