IMPROVING EFFICACY OF FLUORESCENT DIAGNOSTICS OF SKIN AND MUCOSAL TUMORS IN OCULAR ONCOLOGY

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Abstract


Developed in 2006 by our institute, the method of primary detection of skin and mucosal tumors based on non-induced fluorescence of endogenous protoporphyrin IX is used to estimate proliferative activity of tumor and its probable progression. This study was aimed to improve method efficacy by means of additional parameter which would quantitatively describe the interpenetration of tumor and surrounding tissues. The authors analyzed autofluorescent data of 97 patients and determined medico-biological factors which could cause controversal results (all cases were histologically controlled). The coefficient of interpenetration Kdith was proposed as a solution. It is calculated as averaged reciprocal to tumor border probability. Repeated analysis of the autofluorescent images using both the proliferative factor and coefficient of interposition revealed improvement of method specificity from 69% to 85% while sensitivity of method remained 70%. In authors’ opinion, the method can be recommended for use in general oncology and dermatology.

 


I. A. Novikov

Federal State Budget Institution «Scientific Research Institute of Eye Diseases» of Russian Academy of Medical Sciences

Author for correspondence.
Email: toiaia@rambler.ru

Russian Federation старший научный сотрудник научно-организационного отдела ФГБУ «НИИГБ» РАМН Адрес: 119021, Москва, ул. Россолимо, д. 11А Тел.: (499) 248-01-25

Ya. O. Grusha

Federal State Budget Institution «Scientific Research Institute of Eye Diseases» of Russian Academy of Medical Sciences

Email: toiaia@rambler.ru

Russian Federation доктор медицинских наук, профессор, заведующий отделом пластической и реконструк- тивной хирургии век и орбиты ФГБУ «НИИГБ» РАМН Адрес: 119021, Москва, ул. Россолимо, д. 11А Тел.: (499) 248-01-25

N. P. Kirushchenkova

Federal State Budget Institution «Scientific Research Institute of Eye Diseases» of Russian Academy of Medical Sciences

Email: natalfa@yandex.ru

Russian Federation врач-офтальмолог ФГБУ «НИИГБ» РАМН Адрес: 119021, Москва, ул. Россолимо, д. 11А

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