Email this article 
IMPROVING EFFICACY OF FLUORESCENT DIAGNOSTICS OF SKIN AND MUCOSAL TUMORS IN OCULAR ONCOLOGY
- Authors: Novikov I.A.1, Grusha Y.O.1, Kirushchenkova N.P.1
-
Affiliations:
- Federal State Budget Institution «Scientific Research Institute of Eye Diseases» of Russian Academy of Medical Sciences
- Issue: Vol 67, No 10 (2012)
- Pages: 62-69
- Section: SHORT MESSAGES
- Published: 10.10.2012
- URL: https://vestnikramn.spr-journal.ru/jour/article/view/258
- DOI: https://doi.org/10.15690/vramn.v67i10.418
- ID: 258
Cite item
Full Text
Abstract
Developed in 2006 by our institute, the method of primary detection of skin and mucosal tumors based on non-induced fluorescence of endogenous protoporphyrin IX is used to estimate proliferative activity of tumor and its probable progression. This study was aimed to improve method efficacy by means of additional parameter which would quantitatively describe the interpenetration of tumor and surrounding tissues. The authors analyzed autofluorescent data of 97 patients and determined medico-biological factors which could cause controversal results (all cases were histologically controlled). The coefficient of interpenetration Kdith was proposed as a solution. It is calculated as averaged reciprocal to tumor border probability. Repeated analysis of the autofluorescent images using both the proliferative factor and coefficient of interposition revealed improvement of method specificity from 69% to 85% while sensitivity of method remained 70%. In authors’ opinion, the method can be recommended for use in general oncology and dermatology.
About the authors
I. A. Novikov
Federal State Budget Institution «Scientific Research Institute of Eye Diseases» of Russian Academy of Medical Sciences
Author for correspondence.
Email: toiaia@rambler.ru
старший научный сотрудник научно-организационного отдела ФГБУ «НИИГБ» РАМН Адрес: 119021, Москва, ул. Россолимо, д. 11А Тел.: (499) 248-01-25 Россия
Ya. O. Grusha
Federal State Budget Institution «Scientific Research Institute of Eye Diseases» of Russian Academy of Medical Sciences
Email: toiaia@rambler.ru
доктор медицинских наук, профессор, заведующий отделом пластической и реконструк- тивной хирургии век и орбиты ФГБУ «НИИГБ» РАМН Адрес: 119021, Москва, ул. Россолимо, д. 11А Тел.: (499) 248-01-25 Россия
N. P. Kirushchenkova
Federal State Budget Institution «Scientific Research Institute of Eye Diseases» of Russian Academy of Medical Sciences
Email: natalfa@yandex.ru
врач-офтальмолог ФГБУ «НИИГБ» РАМН Адрес: 119021, Москва, ул. Россолимо, д. 11А Россия
References
- Costello M., Luttenberger L. Fluorescence with the Wood's filter as an aid in dermatological diagnosis. N.Y. S. J. Med. 1944; 42: 1778–1784.
- Landsberg G.S. Optika. 6-e izd [Optics. 6th Edition] Мoscow: FIZMATLIT. 2003. 846 p.
- Zellweger M. Fluorescence spectroscopy of exogenous, exogenously-induced and endogenous fluorophores for the photodetection and photodynamic therapy of cancer. École Polytechnique Fédérale de Lausanne. 2000; 2126: 233.
- Sexton M., Johnes D.B., Maloney M.E. Histologic pattern analysis of basal cell carcinoma. Study of a series of 1039 consecutive neoplasms. J. Am. Acad. Dermatol. 1990; 23: 1118-1126.
- Figge F. Fluorescence studies on cancer. Can. Res. 1944; 4 (8): 465–471.
- Osipova E.A. Fluorestsentnye metody issledovaniya opukholei vek i kon"yunktivy na osnove endogennykh i ekzogennykh fluoroforov. Avtoref. dis … kand. med. nauk [The fluorescent research methods of eyelid and conjunctiva tumors on the basis of endogenous and exogenous fluorophores. Abstract for Dissertation for the degree of Candidate of medical science]. Мoscow, 2009.
Supplementary files
