TWO PATTERNS ОF CT-BRAIN PERFUSION AND DC-POTENTIALS ОF THE BRAIN EVOKED COGNITIVE TASK IN DISCIRCULATORY ENCEPHALOPATHY PATIENTS

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Abstract


In patients with discirculatory encephalopathy the influence of verbal fluency test on the characteristics of cerebral perfusion, DC-potentials of the brain, as well as on blood pressure and heart rate was investigated. Two patterns of responses to the verbal fluency test were observed. The first one is the process of generalized activation, manifested by the reduction of the TTP (time to peak) parameters of brain perfusion, the rise of the DC-potentials in all areas of brain and the modulation of blood pressure and heart rate. The second process, directly connected with cognitive processing, was manifested by the shifts of local characteristics of brain perfusion and DC-potentials in the frontal, temporal and central cortex, especially in the left hemisphere. Correlations were found between the characteristics of cerebral perfusion and DC-potentials on the one hand and the number of words during the verbal fluency test performance on the other hand.

 


About the authors

V. F. Fokin

Research Center of Neurology of Russian academy of medical science, Moscow

Author for correspondence.
Email: fvf@mail.ru

Russian Federation доктор биологических наук, профессор, руководитель лаборатории возрастной физио- логии мозга Научного центра неврологии РАМН Адрес: 125367, Москва, Волоколамское ш., д. 80 Тел.: (495) 917-07-65

N. V. Ponomareva

Research Center of Neurology of Russian academy of medical science, Moscow

Email: ponomare@yandex.ru

Russian Federation доктор медицинских наук наук, ведущий научный сотрудник лаборатории воз- растной физиологии мозга Научного центра неврологии РАМН Адрес: 125367, Москва, Волоколамское ш., д. 80 Тел.: (495) 917-07-65

M. V. Krotenkova

Research Center of Neurology of Russian academy of medical science, Moscow

Email: in-ray@yandex.ru

Russian Federation доктор медицинских наук, руководитель отделения лучевой диагностики Научного центра неврологии РАМН Адрес: 125367, Москва, Волоколамское ш., д. 80 Тел.: (495) 490-22-05, факс: (495) 490-41-71

R. N. Konovalov

Research Center of Neurology of Russian academy of medical science, Moscow

Email: in-ray@yandex.ru

Russian Federation кандидат медицинских наук, старший научный сотрудник отделения лучевой диагностики Научного центра неврологии РАМН Адрес: 125367, Москва, Волоколамское ш., д. 80 Тел.: (495) 490-22-05, факс: (495) 490-41-71

M. M. Tanashyan

Research Center of Neurology of Russian academy of medical science, Moscow

Email: angionev@gmail.com

Russian Federation доктор медицинских наук, профессор, зам. директора по научной и лечебной работе, руководитель 1-го сосудистого отделения (общей ангионеврологии) Научного центра неврологии РАМН Адрес: 125367, Москва, Волоколамское ш., д. 80 Тел.: (495) 490-24-02, факс: (495) 490-22-10

O. V. Lagoda

Research Center of Neurology of Russian academy of medical science, Moscow

Email: angionev@gmail.com

Russian Federation кандидат медицинских наук, старший научный сотрудник 1-го сосудистого отделения (общей ангионеврологии) Научного центра неврологии РАМН Адрес: 125367, Москва, Волоколамское ш., д. 80 Тел.: (495) 490-24-02, факс: (495) 490-22-10

References

  1. Hugdahl K. Cognitive influences on human autonomic nervous system function. Curr. Opin. Neurobiol. 1996; 6 (2): 252–258.
  2. Dahle Ch. L, Jacobs B.S., Raz N. Aging, vascular risk and cognition: blood glucose, pulse pressure, and cognitive performance in healthy adults. Psychol. Aging. 2009; 24 (1): 154–162.
  3. Ruff R.M., Light R.H., Parker S.B., Levin H.S. The psychological construct of word fluency. Brain and Language. 1997; 57 (3): 394–405.
  4. Osawa A., Maeshima S., Shimamoto Y., Sekiguchi E, Kakishita K, Ozaki F, Moriwaki. Relationship between cognitive function and regional cerebral blood flow in different types of dementia. Disabil. Rehabil. 2004; 26 (12): 739–745.
  5. Fokin V.F., Ponomareva N.V. Energeticheskaya fiziologiya mozga [Energetic physiology of the brain]. Moscow: Antidor. 2003. 288 p.
  6. Voipio J., Tallgren P., Heinonen E., Vanhatalo, S. & Kaila, K. Millivolt-scale DC shifts in the human scalp EEG: evidence for a nonneuronal generator. J. Neurophysiol. 2003; 89: 2208–2214.
  7. Ponomareva N.V., Kunizheva S.V., Malina D.D., Shcheglova N.S., Rogaev E.I. Neirofiziologicheskie patterny aktivatsii mozga pri kognitivnoi nagruzke u lyudei, geneticheski predraspolozhennykh k bolezni Al'tsgeimera. V kn.: Sovremennye napravleniya issledovanii funktsional'noi mezhpolusharnoi asimmetrii i plastichnosti mozga. Mat-ly konferentsii [Neurophysiological patterns of brain activation in cognitive load in people genetically predisposed to Alzheimer's disease. In.: Modern trends in the study of functional interhemispheric asymmetry and plasticity of the brain.Conference proceedings.]. Pod red. S.N. Illarioshkina, V.F. Fokina [Illarioshkin S.N., Fokin V.F. (editors)] Moscow; 2010. 600–603 p.
  8. Shmidt E.V. Classification of vascular lesions of the brain and spinal cord. Zhurnal nevropatologii i psikhiatrii = Journal of Neurology and Psychiatry. 1985. 1281–1288 p.
  9. Sergeev D.V., Krotenkova M.V., Piradov M.A. Cerebral blood flow in acute hemispheric ischemic stroke: clinical and CT perfusion analysis. Annaly klinicheskoi i eksperimental'noi nevrologii = Annals of clinical and experimental neurology. 2009; 3 (4): 19–27.
  10. Fokin V.F., Ponomareva N.V., Krotenkova M.V., Konovalov R.N., Sergeeva A.N., Tanashyan M.M., Lagoda O.V. Interhemisphere asymmetry of regulation of local cerebral blood flow in patients with dyscirculatory encephalopathy. Vestnik Rossiiskoi akademii meditsinskikh nauk = Annals of the Russian Academy of Medical Sciences. 2010; 6: 13–16.
  11. Nestle B.J. Blood pressure and catecholamine excretion after mental stress in labile hypertension. Lancet. 1969; 293 (7597): 692–694.
  12. Craig A.D. Forebrain emotional asymmetry: a neuroanatomical basis? TRENDS in Cognitive Sciences. 2005; 9 (12): 566–571.
  13. Ponomareva N.V., Fokin V.F., Pavlova O.A., Androsova L.V., Selezneva N.D. Analyzing correlation between neurophysiological parameters and level of stress hormone cortisol in normal aging. Vestnik Rossiiskoi akademii meditsinskikh nauk = Annals of the Russian Academy of Medical Sciences. 1999; 3: 46–49.
  14. Frith C.D., Friston K.J., Liddle P.F, Frackowiak R.S.J. A PET study of word finding. Neuropsychologia. 1991; 29 (12): 1137–1148.
  15. Catani M., Dell'acqua F., Vergani F., Malik F., Hodge H., Roy P., Valabregue R., Thiebaut de Schotten M. Short frontal lobe connections of the human brain. Cortex. 2012; 48 (2):273–291.

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