CLINICAL AND EXPERIMENTAL RESEARCH OF IMMUNOMODULATORY EFFECT OF AMISULPRIDE

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Abstract

Study of immunomodulatory effect of atypical antipsychotic amisulpride has revealed a positive clinical effect after 6-week therapy of schizophrenic patients regarding both positive and negative symptoms. A decrease in activity of humoral immunity factors (В lymphocytes, immunoglobulins, HLA-DR+-cells) identified among schizophrenic patients in the process of amisulpride therapy can be attributed to a positive effect optimizing the ratio Th1/Th2. Amisulpride when used under experimental conditions produced a suppression of IgM-immune response in mice of the C57BL/6J strain. This effect was more expressed in animals with aggressive behavior pattern.

 

About the authors

T. P. Vetlugina

Mental Health Research Institute under the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russian Federation

Author for correspondence.
Email: vetlug@mail.tomsknet.ru
PhD, Professor, Head of Laboratory of Clinical Psychoneuroimmunology, Federal State Budget Institution Scientific Research Institute of Physical Health, Siberian Department, Russian Academy of Medical Sciences. Address: 634014, Tomsk, Aleutskaya str. 4; Tel.: (3822) 72-44-15 Россия

O. A. Lobacheva

Mental Health Research Institute under the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russian Federation

Email: oalobacheva@sibmail.com
PhD, Leading Scientific Worker, Laboratory of Clinical Psychoneuroimmunology, Federal State Budget Institution Scientific Research Institute of Physical Health, Siberian Department, Russian Academy of Medical Sciences. Address: 634014, Tomsk, Aleutskaya str. 4; Tel.: (3822) 72-44-15 Россия

E. L. Al'perina

Research Institute of Physiology under the Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation

Email: e.l.alperina@physiol.ru
PhD, Chief Scientific Worker, Laboratory of Neurochemical Modulation Mechanisms, Federal State Budget Institution Scientific Research Institute of Physiology, Siberian Department, Russian Academy of Medical Sciences. Address: 630117, Novosibirsk, Academician Timakov str. 4; Tel.: (383) 335-98-58 Россия

E. N. Zhukova

Research Institute of Physiology under the Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation

Email: maktub.9@mail.ru
Candidate of Biological Sciences, Scientific Worker, Laboratory of Neurochemical Modulation Mechanisms, Federal State Budget Institution Scientific Research Institute of Physiology, Siberian Department, Russian Academy of Medical Sciences. Address: 630117, Novosibirsk, Academician Timakov str. 4; Tel.: (383) 335-98-58 Россия

A. V. Semke

Mental Health Research Institute under the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russian Federation

Email: asemke@mail.ru
PhD, Professor, Head of Endogenic Disorders Department, Federal State Budget Institution Scientific Research Institute of Psychical Health, Siberian Department, Russian Academy of Medical Sciences. Address: 634014, Tomsk, Aleutskaya str. 4; Tel.: (3822) 72-31-51 Россия

V. B. Nikitina

Mental Health Research Institute under the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russian Federation

Email: valentina08@sibmail.com
PhD, Leading Scientific Worker, Laboratory of Clinical Psychoneuroimmunology, Federal State Budget Institution Scientific Research Institute of psychical Health, Siberian Department, Russian Academy of Medical Sciences. Address: 634014, Tomsk, Aleutskaya str. 4; Tel.: (3822) 72-44-15 Россия

M. A. Cheido

Research Institute of Physiology under the Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation

Email: cheido@physiol.ru
Candidate of Biological Sciences, Leading Scientific Worker, Laboratory of Neurochemical Modulation Mechanisms, Federal State Budget Institution Scientific Research Institute of Physiology, Siberian Department, Russian Academy of Medical Sciences. Address: 630117, Novosibirsk, Academician Timakov str. 4; Tel.: (383) 335-97-58 Россия

G. V. Idova

Research Institute of Physiology under the Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation

Email: galina@physiol.ru
PhD, Professor, Head of Laboratory of Neurochemical Modulation Mechanisms, Federal State Budget Institution Scientific Research Institute of Physiology, Siberian Department, Russian Academy of Medical Sciences. Address: 630117, Novosibirsk, Academician Timakov str. 4; Tel.: (383) 335-97-58 Россия

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