CLINICAL AND EXPERIMENTAL RESEARCH OF IMMUNOMODULATORY EFFECT OF AMISULPRIDE

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  • Authors: Vetlugina T.P.1, Lobacheva O.A.1, Al'perina E.L.2, Zhukova E.N.2, Semke A.V.1, Nikitina V.B.1, Cheido M.A.2, Idova G.V.2
  • Affiliations:
    1. Mental Health Research Institute under the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russian Federation
    2. Research Institute of Physiology under the Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation
  • Issue: Vol 67, No 12 (2012)
  • Pages: 13-17
  • Section: IMMUNOLOGY: CURRENT ISSUES
  • URL: https://vestnikramn.spr-journal.ru/jour/article/view/230
  • DOI: https://doi.org/10.15690/vramn.v67i12.475
  • Cite item

Abstract


Study of immunomodulatory effect of atypical antipsychotic amisulpride has revealed a positive clinical effect after 6-week therapy of schizophrenic patients regarding both positive and negative symptoms. A decrease in activity of humoral immunity factors (В lymphocytes, immunoglobulins, HLA-DR+-cells) identified among schizophrenic patients in the process of amisulpride therapy can be attributed to a positive effect optimizing the ratio Th1/Th2. Amisulpride when used under experimental conditions produced a suppression of IgM-immune response in mice of the C57BL/6J strain. This effect was more expressed in animals with aggressive behavior pattern.

 


T. P. Vetlugina

Mental Health Research Institute under the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russian Federation

Author for correspondence.
Email: vetlug@mail.tomsknet.ru

Russian Federation PhD, Professor, Head of Laboratory of Clinical Psychoneuroimmunology, Federal State Budget Institution Scientific Research Institute of Physical Health, Siberian Department, Russian Academy of Medical Sciences. Address: 634014, Tomsk, Aleutskaya str. 4; Tel.: (3822) 72-44-15

O. A. Lobacheva

Mental Health Research Institute under the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russian Federation

Email: oalobacheva@sibmail.com

Russian Federation PhD, Leading Scientific Worker, Laboratory of Clinical Psychoneuroimmunology, Federal State Budget Institution Scientific Research Institute of Physical Health, Siberian Department, Russian Academy of Medical Sciences. Address: 634014, Tomsk, Aleutskaya str. 4; Tel.: (3822) 72-44-15

E. L. Al'perina

Research Institute of Physiology under the Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation

Email: e.l.alperina@physiol.ru

Russian Federation PhD, Chief Scientific Worker, Laboratory of Neurochemical Modulation Mechanisms, Federal State Budget Institution Scientific Research Institute of Physiology, Siberian Department, Russian Academy of Medical Sciences. Address: 630117, Novosibirsk, Academician Timakov str. 4; Tel.: (383) 335-98-58

E. N. Zhukova

Research Institute of Physiology under the Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation

Email: maktub.9@mail.ru

Russian Federation Candidate of Biological Sciences, Scientific Worker, Laboratory of Neurochemical Modulation Mechanisms, Federal State Budget Institution Scientific Research Institute of Physiology, Siberian Department, Russian Academy of Medical Sciences. Address: 630117, Novosibirsk, Academician Timakov str. 4; Tel.: (383) 335-98-58

A. V. Semke

Mental Health Research Institute under the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russian Federation

Email: asemke@mail.ru

Russian Federation PhD, Professor, Head of Endogenic Disorders Department, Federal State Budget Institution Scientific Research Institute of Psychical Health, Siberian Department, Russian Academy of Medical Sciences. Address: 634014, Tomsk, Aleutskaya str. 4; Tel.: (3822) 72-31-51

V. B. Nikitina

Mental Health Research Institute under the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russian Federation

Email: valentina08@sibmail.com

Russian Federation PhD, Leading Scientific Worker, Laboratory of Clinical Psychoneuroimmunology, Federal State Budget Institution Scientific Research Institute of psychical Health, Siberian Department, Russian Academy of Medical Sciences. Address: 634014, Tomsk, Aleutskaya str. 4; Tel.: (3822) 72-44-15

M. A. Cheido

Research Institute of Physiology under the Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation

Email: cheido@physiol.ru

Russian Federation Candidate of Biological Sciences, Leading Scientific Worker, Laboratory of Neurochemical Modulation Mechanisms, Federal State Budget Institution Scientific Research Institute of Physiology, Siberian Department, Russian Academy of Medical Sciences. Address: 630117, Novosibirsk, Academician Timakov str. 4; Tel.: (383) 335-97-58

G. V. Idova

Research Institute of Physiology under the Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation

Email: galina@physiol.ru

Russian Federation PhD, Professor, Head of Laboratory of Neurochemical Modulation Mechanisms, Federal State Budget Institution Scientific Research Institute of Physiology, Siberian Department, Russian Academy of Medical Sciences. Address: 630117, Novosibirsk, Academician Timakov str. 4; Tel.: (383) 335-97-58

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