Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciences0869-60472414-3545"Paediatrician" Publishers LLC23010.15690/vramn.v67i12.475CLINICAL AND EXPERIMENTAL RESEARCH OF IMMUNOMODULATORY EFFECT OF AMISULPRIDEVetluginaT. P.PhD, Professor, Head of Laboratory of Clinical Psychoneuroimmunology, Federal State Budget Institution Scientific Research Institute of Physical Health, Siberian Department, Russian Academy of Medical Sciences. Address: 634014, Tomsk, Aleutskaya str. 4; Tel.: (3822) 72-44-15vetlug@mail.tomsknet.ruLobachevaO. A.PhD, Leading Scientific Worker, Laboratory of Clinical Psychoneuroimmunology, Federal State Budget Institution Scientific Research Institute of Physical Health, Siberian Department, Russian Academy of Medical Sciences. Address: 634014, Tomsk, Aleutskaya str. 4; Tel.: (3822) 72-44-15oalobacheva@sibmail.comAl'perinaE. L.PhD, Chief Scientific Worker, Laboratory of Neurochemical Modulation Mechanisms, Federal State Budget Institution Scientific Research Institute of Physiology, Siberian Department, Russian Academy of Medical Sciences. Address: 630117, Novosibirsk, Academician Timakov str. 4; Tel.: (383) 335-98-58e.l.alperina@physiol.ruZhukovaE. N.Candidate of Biological Sciences, Scientific Worker, Laboratory of Neurochemical Modulation Mechanisms, Federal State Budget Institution Scientific Research Institute of Physiology, Siberian Department, Russian Academy of Medical Sciences. Address: 630117, Novosibirsk, Academician Timakov str. 4; Tel.: (383) 335-98-58maktub.9@mail.ruSemkeA. V.PhD, Professor, Head of Endogenic Disorders Department, Federal State Budget Institution Scientific Research Institute of Psychical Health, Siberian Department, Russian Academy of Medical Sciences. Address: 634014, Tomsk, Aleutskaya str. 4; Tel.: (3822) 72-31-51asemke@mail.ruNikitinaV. B.PhD, Leading Scientific Worker, Laboratory of Clinical Psychoneuroimmunology, Federal State Budget Institution Scientific Research Institute of psychical Health, Siberian Department, Russian Academy of Medical Sciences. Address: 634014, Tomsk, Aleutskaya str. 4; Tel.: (3822) 72-44-15valentina08@sibmail.comCheidoM. A.Candidate of Biological Sciences, Leading Scientific Worker, Laboratory of Neurochemical Modulation Mechanisms, Federal State Budget Institution Scientific Research Institute of Physiology, Siberian Department, Russian Academy of Medical Sciences. Address: 630117, Novosibirsk, Academician Timakov str. 4; Tel.: (383) 335-97-58cheido@physiol.ruIdovaG. V.PhD, Professor, Head of Laboratory of Neurochemical Modulation Mechanisms, Federal State Budget Institution Scientific Research Institute of Physiology, Siberian Department, Russian Academy of Medical Sciences. Address: 630117, Novosibirsk, Academician Timakov str. 4; Tel.: (383) 335-97-58galina@physiol.ruMental Health Research Institute under the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russian FederationResearch Institute of Physiology under the Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation101220126712131707082015Copyright © 2012, "Paediatrician" Publishers LLC2012<p class="Text05"><em>Study of immunomodulatory effect of atypical antipsychotic amisulpride has revealed a positive clinical effect after 6-week therapy of schizophrenic patients regarding both positive and negative symptoms. A decrease in activity of humoral immunity factors (</em><em>В</em><em> lymphocytes, immunoglobulins, HLA-DR<sup>+</sup>-cells) identified among schizophrenic patients in the process of amisulpride therapy can be attributed to a positive effect optimizing the ratio Th<sub>1</sub>/Th<sub>2</sub>. Amisulpride when used under experimental conditions produced a suppression of IgM-immune response in mice of the C57BL/6J strain. This effect was more expressed in animals with aggressive behavior pattern.</em></p><p class="Text05"> </p>amisulprideschizophreniaC57BL/6J micecellular immunityhumoral immunityIgM-immune responseамисульпридшизофрениямыши линии С57BL/6Jклеточный иммунитетгуморальный иммунитетIgM-иммунный ответ[1. Mosolov S.N., Ryvkin P.V., Serditov O.V., Ladyzhenskii M.Ya., Potapov A.V. Metabolic side effects of modern antipsychotic drug therapy. Sotsial'naya i klinicheskaya psikhiatriya = Social and clinical psychiatry. 2008; 3: 75–90.][2. Gorobets L.N., Matrosova M.I., Shmukler A.B. Dynamics of clinical and endocrine, hormonal, biochemical, anthropometric and physical performance in patients with schizophrenia and schizophrenia spectrum disorders during treatment with sertindole. 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