EFFICIENCY OF MILDRONATE IN RATS OF DIFFERENT AGE WITH EXPERIMENTAL-INDUCED MYOCARDIAL ISCHEMIA

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Abstract


Under experimental myocardial ischemia in rats of 10 months treatment with mildronate resulted in essential changes in metabolism of cardiomyocites. This includes stimulation of aerobic and anaerobic ways of power supply of heart cells: activation of glycolysis, oxidative phosphorylation and oxidative pyruvate decarboxylation with restoration of adenosine triphosphate pool to intact rats level in myocardium, serum and erythrocytes with signs of stabilization of cardiomyocytes membranes and essential decrease of tissue hypoxia. Introduction of mildronate to old rats (24 months) with an experimental myocardium ischemia was accompanied by lesser expressed changes of metabolism: activation of glycolysis and oxidative pyruvate decarboxylation without stimulation of Crebs’ cycle enzymes. This became sufficient for restoration of adenosine triphosphate pool in myocardium without change of its quantity in serum and erythrocytes with signs of stabilization of cardiomyocytes membranes and moderate reduction of tissue hypoxia degree.


V. G. Kukes

I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation

Email: Romashenko@bsu.edu.ru

Russian Federation

PhD, Professor, Academician of the Russian Academy of Medical Science, Head of Department of Clinical Pharmacology and Propaedeutics of Internal Diseases I.M. Sechenov First Moscow State Medical University, Director of Institute of Clinical Pharmacology, Branch Director of «Clinical Pharmacology» Scientific Center of Biomedical Technologies of the Russian Academy of Medical Science
Address: 119048, Moscow, Trubetskaya St., 8 

N. I. Zhernakova

Belgorod State National Research University, Russian Federation

Email: Romashenko@bsu.edu.ru

Russian Federation

PhD, Professor, Dean of the Medical Faculty of Belgorod State National Research University Address: 308015, Belgorod, Victory St., 85 

T. V. Gorbach

Kharkov State Medical University, Ukraine

Email: Romashenko@bsu.edu.ru

Ukraine

PhD, Associate Professor of Biochemistry, Kharkov State Medical University
Address: Ukraine, 61022, Kharkov, Lenin Avenue 4 

O. V. Romashchenko

Belgorod State National Research University, Russian Federation

Author for correspondence.
Email: Romashenko@bsu.edu.ru

Russian Federation PhD, Associate Professor of Biochemistry and Pharmacology, Belgorod State National Research University
Address: 308015, Belgorod, Victory St., 85

V. V. Rumbesht

Belgorod State National Research University, Russian Federation

Email: Romashenko@bsu.edu.ru

Russian Federation

PhD, Associate professor of Mathematical and Software information systems, Belgorod State National Research University
Address: 308015, Belgorod, Victory St., 85

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