Email this article 
EFFICIENCY OF MILDRONATE IN RATS OF DIFFERENT AGE WITH EXPERIMENTAL-INDUCED MYOCARDIAL ISCHEMIA
- Authors: Kukes V.G.1, Zhernakova N.I.2, Gorbach T.V.3, Romashchenko O.V.2, Rumbesht V.V.2
-
Affiliations:
- I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
- Belgorod State National Research University, Russian Federation
- Kharkov State Medical University, Ukraine
- Issue: Vol 68, No 1 (2013)
- Pages: 42-46
- Section: PHARMACOLOGY: CURRENT ISSUES
- URL: https://vestnikramn.spr-journal.ru/jour/article/view/223
- DOI: https://doi.org/10.15690/vramn.v68i1.536
- ID: 223
Cite item
Full Text
Abstract
Under experimental myocardial ischemia in rats of 10 months treatment with mildronate resulted in essential changes in metabolism of cardiomyocites. This includes stimulation of aerobic and anaerobic ways of power supply of heart cells: activation of glycolysis, oxidative phosphorylation and oxidative pyruvate decarboxylation with restoration of adenosine triphosphate pool to intact rats level in myocardium, serum and erythrocytes with signs of stabilization of cardiomyocytes membranes and essential decrease of tissue hypoxia. Introduction of mildronate to old rats (24 months) with an experimental myocardium ischemia was accompanied by lesser expressed changes of metabolism: activation of glycolysis and oxidative pyruvate decarboxylation without stimulation of Crebs’ cycle enzymes. This became sufficient for restoration of adenosine triphosphate pool in myocardium without change of its quantity in serum and erythrocytes with signs of stabilization of cardiomyocytes membranes and moderate reduction of tissue hypoxia degree.
About the authors
V. G. Kukes
I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
Email: Romashenko@bsu.edu.ru
PhD, Professor, Academician of the Russian Academy of Medical Science, Head of Department of Clinical Pharmacology and Propaedeutics of Internal Diseases I.M. Sechenov First Moscow State Medical University, Director of Institute of Clinical Pharmacology, Branch Director of «Clinical Pharmacology» Scientific Center of Biomedical Technologies of the Russian Academy of Medical Science
Address: 119048, Moscow, Trubetskaya St., 8
N. I. Zhernakova
Belgorod State National Research University, Russian Federation
Email: Romashenko@bsu.edu.ru
PhD, Professor, Dean of the Medical Faculty of Belgorod State National Research University Address: 308015, Belgorod, Victory St., 85
Russian FederationT. V. Gorbach
Kharkov State Medical University, Ukraine
Email: Romashenko@bsu.edu.ru
PhD, Associate Professor of Biochemistry, Kharkov State Medical University
Address: Ukraine, 61022, Kharkov, Lenin Avenue 4
O. V. Romashchenko
Belgorod State National Research University, Russian Federation
Author for correspondence.
Email: Romashenko@bsu.edu.ru
PhD, Associate Professor of Biochemistry and Pharmacology, Belgorod State National Research University
Address: 308015, Belgorod, Victory St., 85 Russian Federation
V. V. Rumbesht
Belgorod State National Research University, Russian Federation
Email: Romashenko@bsu.edu.ru
PhD, Associate professor of Mathematical and Software information systems, Belgorod State National Research University
Address: 308015, Belgorod, Victory St., 85
References
- Kharchenko V.I., Kakorina E.P., Koryakin M.V., Virin M.M., Sharapova G.A. Supermortality Russian population from diseases of the circulatory system in comparison with developed countries. Problemy prognozirovaniya = Problems of forecasting. 2006; 12 (5): 138–151.
- Ratmanova A. Cardiovascular morbidity and mortality - statistics for European countries (2008). Medicine Review = Medicine Review. 2009; 6 (1): 6–12.
- Diagnosis and treatment of stable angina. Russian recommendations (second revision). Developed by the Committee of Experts of Russian National Scientific Society of Cardiology. Kardiovaskulyarnaya terapiya i profilaktika = Cardiovascular therapy and prophylaxis. 2008; 7 (8): 40.
- Astashkin E.I. Correction of energy metabolism in the myocardium - a new direction in the treatment of cardiovascular diseases. Serdtse i metabolism = Heart and metabolism. 2008; 21: 1–3.
- Mazur N.A. herapy in patients with chronic ischemic heart disease and the actual state of the problem in practical public health. Klinich. meditsina = Clinical medicine. 2007; 8: 19–25.
- Gaman D.V., Konopenko M.I., Tyubka T.Yu. Features morphofunctional cardiac ultrastructure in experimental myocardial ischemia. Ukr. biofarmatsevticheskii zhurn. = Ukrainian biopharmaceutical journal. 2011; 10 (5): 16–20.
- Rybolovlev Yu.R., Rybolovlev R.S. Dosage substances constants for mammalian biological activity. Dokl. AN SSSR = Reports of USSR Academy of Sciences. 1979; 6: 1513–1516.
- Praktikum po biokhimii. Pod red. prof. N.P. Meshkovoi, S.E. Severina [Workshop on Biochemistry. Edited by N.P. Meshkova, S.E. Severin]. Moscow, MGU, 1979. 485 p.
- Mranova I.S. Definition 2 3DFG and ATP in erythrocytes. Laboratornoe delo = Laboratory work. 1975; 7: 652–654.
- Metody biokhimicheskikh issledovanii. Pod red. prof. M.I. Prokhorovoi [Methods of biochemical research. Edited by M.I. Prokhorova]. Leningrad, LGU, 1982. 270 p.
- Kalvin'sh I.Ya. Mildronat i mekhanizmy optimizatsii kletochnogo proizvodstva energii v usloviyakh kislorodnogo golodaniya. Tserebrokardial'naya patologiya — novoe v diagnostike i lechenii: Mat-ly III Mezhdunar. Simpoziuma [Mildronat and optimization mechanisms of cellular energy production in conditions of oxygen starvation. Cerebrocardial pathology - new in the diagnosis and treatment: Materials of III International Symposium]. Sudak, 2001. pp. 3–16.
- Kalvin'sh I.Ya. Synthesis and biological activity of new bioregulator - mildronata. Eksperim. i klinich. farmakoterapiya = Experimental and clinical pharmacotherapy. 1991; 19: 7-–14.
- Malyshev I.Yu., Manukhina E.B. Stress, adaptation, and nitric oxide. Biokhimiya = Biochemistry. 1998; 63 (7): 992–1006.
- Manukhina E.B., Malyshev I.Yu. Stress-limiting system of nitric oxide. Ros. fiziol. zhurn. im. I.M.Sechenova = I.M.Sechenov Russian physiological journal. 2000; 86 (10): 1283–1292.
- Geichenko V.P., Kuryata A.V., Muzhchil' (Romashchenko) O.V. Serdechnaya nedostatochnost'. Mekhanizmy razvitiya, rol' narushenii metabolizma i adaptatsii, strategii lecheniya: Monografiya [Heart failure. Mechanisms of development, the role of metabolic disorders and adaptation strategies for treatment: Monograph.]. Dnepropetrovsk, Lira-LTD, 2007. 216 p.
Supplementary files
