CEREBROLYSIN FOR ACUTE ISCHEMIC STROKE

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Abstract


The review discusses existing evidence of benefits and risks of cerebrolysin ― a mixture of low-molecular-weight peptides and amino acids derived from pigs’ brain tissue with proposed neuroprotective and neurotrophic properties, for acute ischemic stroke. The review presents results of systematic search and analysis of randomised clinical trials comparing cerebrolysin with placebo in patients with acute ischemic stroke. Only one trial was selected as meeting quality criteria. No difference in death and adverse events between cerebrolysin and placebo was established. The authors conclude about insufficiency of evidence to evaluate the effect of cerebrolysin on survival and dependency in people with acute ischemic stroke.

 


L. Е. Ziganshina

Kazan (Volga Region) Federal University, Kazan, the Republic of Tatarstan, Russian Federation

Author for correspondence.
Email: lezign@gmail.com

Russian Federation PhD, Professor, Head of the Department of Fundamental and Clinical Pharmacology Address: 420008, Kazan, Kremlin St., 18; tel.: (843) 233-73-07

T. R. Abakumova

Kazan (Volga Region) Federal University, Kazan, the Republic of Tatarstan, Russian Federation

Email: abakumovatarud@mail.ru

Russian Federation

PhD, Associate Professor of the Department of Fundamental and Clinical Pharmacology Address: 420008, Kazan, Kremlin St., 18; tel.: (843) 233-73-07

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