ЦЕРЕБРОЛИЗИН В ЛЕЧЕНИИ ОСТРОГО ИШЕМИЧЕСКОГО ИНСУЛЬТА

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Аннотация

В обзоре обсуждаются существующие доказательства пользы и рисков применения церебролизина ― смеси низкомолекулярных пептидов и аминокислот, полученных из мозговой ткани свиней, с заявленными нейропротективными и нейротрофическими свойствами для лечения острого ишемического инсульта. Авторами проведен систематический поиск и анализ рандомизированных контролируемых клинических испытаний, сравнивающих церебролизин с плацебо у пациентов с острым ишемическим инсультом. На основании критического анализа и оценки пригодности для систематического рассмотрения авторами выбрано единственное исследование, удовлетворяющее критериям качества. Показано отсутствие различий между церебролизином и плацебо по влиянию на смерть и неблагоприятные события. Обоснован вывод об отсутствии достаточных доказательств влияния церебролизина на выживаемость и инвалидизацию при остром ишемическом инсульте.

 

Об авторах

Л. Е. Зиганшина

Казанский (Приволжский) федеральный университет, Республика Татарстан, Российская Федерация

Автор, ответственный за переписку.
Email: lezign@gmail.com
PhD, Professor, Head of the Department of Fundamental and Clinical Pharmacology Address: 420008, Kazan, Kremlin St., 18; tel.: (843) 233-73-07 Россия

Т. Р. Абакумова

Казанский (Приволжский) федеральный университет, Республика Татарстан, Российская Федерация

Email: abakumovatarud@mail.ru

PhD, Associate Professor of the Department of Fundamental and Clinical Pharmacology Address: 420008, Kazan, Kremlin St., 18; tel.: (843) 233-73-07

Россия

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