CARDIAC NATRIURETIC PEPTIDES AND HYPERTENSION: EXPERIMENTAL STUDY

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  • Authors: Maximov V.F.1, Korostyshevskaya I.M.1, Markel' A.L.2, Filyushina E.E.1, Yakobson G.S.1
  • Affiliations:
    1. State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation
    2. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
  • Issue: Vol 68, No 1 (2013)
  • Pages: 4-9
  • Section: CARDIOLOGY: CURRENT ISSUES
  • URL: https://vestnikramn.spr-journal.ru/jour/article/view/218
  • DOI: https://doi.org/10.15690/vramn.v68i1.531
  • Cite item

Abstract


The peculiarities of cardiac natriuretic peptide secretion have been investigated during ontogenesis using the hypertonic disease model in ISIAH rat line (with inherited stress induced arterial hypertension). The qualitative and quantitative ultrastructural investigations of right atrium myocardium revealed that the cardiac hormonal synthetic and secretory activities in ISIAH rats are higher as compared with normotensive even-aged rats from control group. Secretory hyperactivity of atrial myocytes in ISIAH rats during early ontogeny precedes the manifestations of hereditary hypertension. Natriuretic peptides present the hypotensive circuit of hemodynamic regulation during the whole ontogeny and the complementary chain in hypertension development.

 


V. F. Maximov

State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk,
Russian Federation

Author for correspondence.
Email: kor@physiol.ru

Russian Federation

PhD, Chief Research Scientist of Research Institute of Physiology Siberian Branch of the Russian Academy of Medical Sciences
Address: 630117, Moscow, Timakov st., 4, tel.: (383) 334-89-70

I. M. Korostyshevskaya

State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk,
Russian Federation

Email: kor@physiol.ru

Russian Federation PhD, Leading Research Scientist of Research Institute of Physiology Siberian Branch of the Russian Academy of Medical Sciences
Address: 630117, Moscow, Timakov st., 4, tel.: (383) 334-89-70

A. L. Markel'

Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation

Email: markel@bionet.nsc.ru

Russian Federation

D.Biol.Sc., Chief Research Scientist of Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Medical Sciences
Address: 630090, Novosibirsk, Lavrentiev avenue, 10, tel.: (383) 363-49-35

E. E. Filyushina

State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk,
Russian Federation

Email: eefil@physiol.ru

Russian Federation PhD, Leading Research Scientist of Research Institute of Physiology Siberian Branch of the Russian Academy of Medical Sciences
Address: 630117, Moscow, Timakov st. 4, tel.: (383) 334-89-61

G. S. Yakobson

State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk,
Russian Federation

Email: jakobsongs@ngs.ru

Russian Federation

Academician of the Russian Academy of Medical Science, Сhief Research Scientist of Research Institute of Physiology Siberian Branch of the Russian Academy of Medical Sciences
Address: 630117, Novosibirsk, Timakov st. 4, tel.: (383) 334-89-61

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