CARDIAC NATRIURETIC PEPTIDES AND HYPERTENSION: EXPERIMENTAL STUDY

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Abstract

The peculiarities of cardiac natriuretic peptide secretion have been investigated during ontogenesis using the hypertonic disease model in ISIAH rat line (with inherited stress induced arterial hypertension). The qualitative and quantitative ultrastructural investigations of right atrium myocardium revealed that the cardiac hormonal synthetic and secretory activities in ISIAH rats are higher as compared with normotensive even-aged rats from control group. Secretory hyperactivity of atrial myocytes in ISIAH rats during early ontogeny precedes the manifestations of hereditary hypertension. Natriuretic peptides present the hypotensive circuit of hemodynamic regulation during the whole ontogeny and the complementary chain in hypertension development.

 

About the authors

V. F. Maximov

State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk,
Russian Federation

Author for correspondence.
Email: kor@physiol.ru

PhD, Chief Research Scientist of Research Institute of Physiology Siberian Branch of the Russian Academy of Medical Sciences
Address: 630117, Moscow, Timakov st., 4, tel.: (383) 334-89-70

Russian Federation

I. M. Korostyshevskaya

State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk,
Russian Federation

Email: kor@physiol.ru
PhD, Leading Research Scientist of Research Institute of Physiology Siberian Branch of the Russian Academy of Medical Sciences
Address: 630117, Moscow, Timakov st., 4, tel.: (383) 334-89-70 Russian Federation

A. L. Markel'

Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation

Email: markel@bionet.nsc.ru

D.Biol.Sc., Chief Research Scientist of Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Medical Sciences
Address: 630090, Novosibirsk, Lavrentiev avenue, 10, tel.: (383) 363-49-35

Russian Federation

E. E. Filyushina

State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk,
Russian Federation

Email: eefil@physiol.ru
PhD, Leading Research Scientist of Research Institute of Physiology Siberian Branch of the Russian Academy of Medical Sciences
Address: 630117, Moscow, Timakov st. 4, tel.: (383) 334-89-61 Russian Federation

G. S. Yakobson

State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk,
Russian Federation

Email: jakobsongs@ngs.ru

Academician of the Russian Academy of Medical Science, Сhief Research Scientist of Research Institute of Physiology Siberian Branch of the Russian Academy of Medical Sciences
Address: 630117, Novosibirsk, Timakov st. 4, tel.: (383) 334-89-61

Russian Federation

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