Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC21810.15690/vramn.v68i1.531CARDIOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ КАРДИОЛОГИИCARDIAC NATRIURETIC PEPTIDES AND HYPERTENSION: EXPERIMENTAL STUDYНАТРИЙУРЕТИЧЕСКИЕ ПЕПТИДЫ СЕРДЦА И АРТЕРИАЛЬНАЯ ГИПЕРТЕНЗИЯ: ЭКСПЕРИМЕНТАЛЬНОЕ ИССЛЕДОВАНИЕMaximovV. F.МаксимовВ. Ф.
Russian Federation

PhD, Chief Research Scientist of Research Institute of Physiology Siberian Branch of the Russian Academy of Medical Sciences Address: 630117, Moscow, Timakov st., 4, tel.: (383) 334-89-70

kor@physiol.ruKorostyshevskayaI. M.КоростышевскаяИ. М.
Russian Federation

PhD, Leading Research Scientist of Research Institute of Physiology Siberian Branch of the Russian Academy of Medical Sciences Address: 630117, Moscow, Timakov st., 4, tel.: (383) 334-89-70

kor@physiol.ruMarkel'A. L.МаркельА. Л.
Russian Federation

D.Biol.Sc., Chief Research Scientist of Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Medical Sciences Address: 630090, Novosibirsk, Lavrentiev avenue, 10, tel.: (383) 363-49-35

markel@bionet.nsc.ruFilyushinaE. E.ФилюшинаЕ. Е.
Russian Federation

PhD, Leading Research Scientist of Research Institute of Physiology Siberian Branch of the Russian Academy of Medical Sciences Address: 630117, Moscow, Timakov st. 4, tel.: (383) 334-89-61

eefil@physiol.ruYakobsonG. S.ЯкобсонГ. С.
Russian Federation

Academician of the Russian Academy of Medical Science, Сhief Research Scientist of Research Institute of Physiology Siberian Branch of the Russian Academy of Medical Sciences Address: 630117, Novosibirsk, Timakov st. 4, tel.: (383) 334-89-61

jakobsongs@ngs.ruState Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian FederationНИИ физиологии Сибирского отделения РАМН, Новосибирск, Российская ФедерацияInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian FederationИнститут цитологии и генетики Сибирского отделения РАН, Новосибирск, Российская Федерация22012013681Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук4907082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/218

The peculiarities of cardiac natriuretic peptide secretion have been investigated during ontogenesis using the hypertonic disease model in ISIAH rat line (with inherited stress induced arterial hypertension). The qualitative and quantitative ultrastructural investigations of right atrium myocardium revealed that the cardiac hormonal synthetic and secretory activities in ISIAH rats are higher as compared with normotensive even-aged rats from control group. Secretory hyperactivity of atrial myocytes in ISIAH rats during early ontogeny precedes the manifestations of hereditary hypertension. Natriuretic peptides present the hypotensive circuit of hemodynamic regulation during the whole ontogeny and the complementary chain in hypertension development.

Особенности секреции сердечных натрийуретических пептидов изучали на модели гипертонической болезни у крыс с наследственной индуцированной стрессом артериальной гипертензией по ходу онтогенеза (линии НИСАГ). Ультраструктурные качественные и количественные исследования миокарда правого предсердия показали, что активность синтеза и секреции сердечных гормонов у крыс линии НИСАГ выше, чем у нормотензивных одновозрастных животных. Секреторная гиперактивность предсердных миоцитов у крыс линии НИСАГ на ранних этапах онтогенеза предшествует проявлению наследственной гипертензии. Натрийуретические пептиды служат гипотензивным контуром в регуляции гемодинамики на всех этапах онтогенеза и дополнительным к другим гормональным системам регуляторным звеном формирования гипертензии.

cardiac natriuretic peptideshearthypertensionexperimentнатрийуретические пептидысердцегипертензияэксперимент1. de Bold A.J., Bruneau B.G., de Bold M.L. Mechanical and neuroendocrine regulation of the endocrine heart. Cardiovasc. Res. 1996; 31: 7–18.2. D`Souza S.P., Davis M., Baxter G.F. Autocrine and paracrine actions of natriuretic peptides in the heart. Pharmacol. Ther. 2004; 101 (2): 113–129.3. Clerico A., Ry S.D, Giannessi D. Measurement of cardiac natriuretic hormones (atrial natriuretic peptide, brain natriuretic peptide, and related peptides) in clinical practice: the need for a new generation of immunoassay methods. Clin. Chemistry. 2000; 46: 1529–1534.4. Maksimov V.F., Korostyshevskaya I.M. Hormonal system of the heart as a link in the regulation of hemodynamics and water-salt homeostasis. Ross. fiziol. zhurn. im. I.M. Sechenova = I.M. Sechenov Russian physiological journal. 2011; 97 (3): 263–275.5. Korostyshevskaya I.M., Maksimov V.F. Where and when in the heart of natriuretic peptides are secreted. Ontogenez = Ontogeny. 2012; 43 (3): 217–228.6. Markel' A.L. Genetic model of stress-induced hypertension. Izv. AN SSSR. Ser. biol. = Annals of USSR Academy of Sciences. Edition Biology. 1985; 3: 466–469.7. Maslova L.N., Shishkina G.N., Bulygina V.V. et al. Brain catecholamines and hypothalamohypophysial and adrenocortical system with hereditary hypertension. Ross. fiziol. zhurn. im. I.M. Sechenova = I.M. Sechenov Russian physiological journal. 1996; 82 (4): 30–38.8. Shmerling M.D., Buzueva I.I., Korostyshevskaya I.M. et al. Stereomorfometricheskoe study of target organs in rats with genetic hypertension in different periods of postnatal ontogenesis feeding conditions change. Morfologiya = Morphology. 2005; 128 (4): 85–90.9. Kawakami H., Okayama H., Hamada M. et al. Alteration of atrial natriuretic peptide and brain natriuretic peptide gene expression associated with progression and regression of cardiac hypertrophy in renovascular hypertensive rats. Clin. Sci. 1996; 90: 197–204.10. Clerico A., Emdin M. Diagnostic accuracy and prognostic relevance of the measurement of cardiac natriuretic peptides: a rewien. Clin. Chem. 2004; 50: 33–50.11. Goetze J.P. Biosynthesis of cardiac natriuretic peptides. Results Probl. Cell Differ. 2010; 50: 97–120.12. Qing G., Garcia R. Characterisation of plasma and tissue atrial natriuretic factor during development of moderate high output heart failure in the rat. Cardiovasc. Res. 1993; 27 (3): 464–470.13. Goetze J.P., Kastrup J., Rehfeld J.F. The paradox of increased natriuretic hormones in congestive heart failure patients: does the endocrine heart also fail in heart failure? Eur. Heart. J. 2003; 24: 1471–1472.14. Vesely D.L. Discovery of new cardiovascular hormones for the treatment of congestive heart failure. Cardiovasc. Hematol. Disord. Targets. 2007; 7 (1): 47–62.15. Ogawa T., Vatta M., Bruneau B.G. et al. Characterization of natriuretic peptide production by adult heart atria. Am. J. Physiol. Heart. Circ. Physiol. 1999; 276 (Issue 6): 1977–1986.16. Cameron V.A., Ellmers L.J. Minireview: natriuretic peptides during development of the fetal heart and circulation. Endocrinology. 2003; 144 (6): 2191–2194.