ROLE OF CIRCULATING ANGIOGENIC FACTORS IN DIABETIC KIDNEY DISEASE

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Abstract


This original article contains the authors own data on homeostasis of angiogenic growth factors (vascular endothelial growth factor — VEGF, angiopoietin 1 and 2 — Ang-1, Ang-2) in diabetic kidney disease. The aims of study were evaluation of alteration on serum concentration of circulating VEGF, Ang-1 and Ang-2, and of their association with markers of renal damage (albuminuria, glomerular filtration rate) and anemia in patients with diabetes mellitus. We studied 78 patients type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Among this group 37 patients had chronic kidney disease. The serum level of VEGF was elevated in T1DM patients and was associated with degree of proteinuria. The serum concentration of Ang-2 was higher in patients with chronic kidney disease (T1DM and T2DM), renal failure (T1DM), proteinuria and anemia (T2DM). Ang-2 strongly associated with albuminuria (T1DM and T2DM), glomerular filtration rate (T1DM) and hemoglobin (T2DM). Obtained results demonstrate that levels of VEGF and Ang-2 (but not Ang-1) are raised in patients with diabetic kidney disease and associated with markers of renal damage and anemia. These data indicate the presence of the disturbance of angiogenic growth factors (VEGF, Ang-2) homeostasis and activity in diabetic patients with chronic kidney disease.


S. A. Martynov

Scientific Centre of Endocrinology, Moscow, Russian Federation

Author for correspondence.
Email: smartynov@inbox.ru

Russian Federation PhD, Leading Research Worker, Endocrinology Research Center Address: 117036, Moscow, Dmitriya Ul’yanova St., 11; tel: (495) 500-01-45

M. V. Shestakova

Scientific Centre of Endocrinology, Moscow, Russian Federation

Email: nephro@endocrincentr.ru

Russian Federation

RAMS cor. member, PhD, Professor, Director of Diabetes Institute, Endocrinology Research Center Address: 117036, Moscow, Dmitriya Ul’yanova St., 11; tel: (499) 124-45-00

I. M. Kutyrina

I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation

Email: nephro@endocrincentr.ru

Russian Federation

PhD, Professor, Leading Research Worker, Department of Nephrology Research Center, I.M. Sechenov First Moscow State Medical University Address: 119992, Moscow, Rossolimo St., 11/4, tel.: (499) 248-41-66

A. V. Il’in

Scientific Centre of Endocrinology, Moscow, Russian Federation

Email: viktor.ilin2011@inbox.ru

Russian Federation

Head of the Laboratory of Clinical Biochemistry, Endocrinology Research Center Address: 117036, Moscow, Dmitriya Ul’yanova St., 11; tel: (499) 126-76-00

M. I. Arbuzova

Scientific Centre of Endocrinology, Moscow, Russian Federation

Email: margarita.arbuzova2010@inbox.ru

Russian Federation

PhD, Leading Research Worker, Laboratory of Clinical Biochemistry, Endocrinology Research Center Address: 117036, Moscow, Dmitriya Ul’yanova St., 11; tel: (499) 612-78-58

I. I. Dedov

Scientific Centre of Endocrinology, Moscow, Russian Federation

Email: nephro@endocrincentr.ru
RAS and RAMS academician, PhD, Professor, RAMS president, Director of Endocrinology Research Center Address: 117036, Moscow, Dmitriya Ul’yanova St., 11; tel: (499) 124-43-00

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