The Relationship between Inflammation and Hemostasis Disorders in Cardiovascular and Infectious Diseases

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Thrombosis and inflammation develop concomitantly during inflammatory, cardiovascular and infectious diseases. Thrombosis induces inflammation and immune system disruption, while inflammation leads to increased hemostasis a vascular thrombosis. Combined use of anti-inflammatory and antithrombotic drugs often leads to adverse effects, for example, nonsteroidal anti-inflammatory drugs induce gastric ulcers, aggravated by bleeding. Vascular endothelial dysfunction plays an important role in the development of thrombosis and inflammation, therefore, research and development of drugs improving endothelial function is a promising approach to preventing thrombotic events arising from inflammation or infectious disease.

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About the authors

Vladimir V. Bykov

Innovative Pharmacological Research LLC; Siberian State Medical University

ORCID iD: 0000-0002-5145-2184
SPIN-code: 1202-3719


Russian Federation, 79/4, Elizarovikh str., 634021, Tomsk; Tomsk

Aleksandr I. Vengerovskii

Siberian State Medical University

ORCID iD: 0000-0001-5094-3742
SPIN-code: 8818-0543
ResearcherId: P-8522-2016

MD, PhD, Professor

Russian Federation, Tomsk

Vladimir V. Udut

Goldberg Research Institute of Pharmacology and Regenerative Medicine; Tomsk National Research Medical Center of the Russian Academy of Sciences

Author for correspondence.
ORCID iD: 0000-0002-3829-7132
SPIN-code: 8645-9815
ResearcherId: A-4208-2017

MD, PhD, Professor, Corresponding Member of the RAS

Russian Federation, Tomsk


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