HORMONAL-METABOLIC PATTERN OF POSTMENOPAUSAL FEMALES WITH NEW ONSET OF DIABETES MELLITUS TYPE 2: THE ROLE OF CANCER AND HEREDITARY PREDISPOSITION TO DIABETES

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Abstract

85 females were studied, 35 females had new onset of diabetes (DM2) and in 50 women DM2 was associated with recently diagnosed cancer (C+DM2). Group C+DM2 was characterized by higher levels of body mass index, insulinemia, estradiolemia, interleukin 6 in serum, and glyoxalase I activity in mononuclears. At the same time  patients in C+DM2 group who had familial predisposition to DM2 were characterized by lower body mass index, body fat content, waist circumference, insulinemia, serum interleukin 6, viscosity of erythrocyte membranes and percent of comets in mononuclears in comparison with patients without familial predisposition to DM2. These trends were mostly opposite to the data of subgroups comparison (with or without relatives with DM2) in females with DM2 without cancer. The conclusion is made that the hereditary load with DM2 is differently realized in diabetics with higher or lower predisposition to cancer that deserves further study.

 

About the authors

L. M. Berstein

N.N. Petrov Research Institute of Oncology, St. Petersburg, Russian Federation

Author for correspondence.
Email: levmb@endocrin.spb.ru
PhD, Professor, Head of Oncoendocrinology Laboratory, Research Institute of Oncology named after N.N. Petrov Address: 197758, St. Petersburg, Pesochnyi Village, Leningradskaya St., 68; tel.: (812) 596-86-54 Russian Federation

D. A. Vasil’ev

N.N. Petrov Research Institute of Oncology, St. Petersburg, Russian Federation

Email: dvasilyev@hotmail.com
PhD, Senior Research Worker, Laboratory of Oncoendocrinology, Research Institute of Oncology named after N.N. Petrov Address: 197758, St. Petersburg, Pesochnyi Village, Leningradskaya St., 68; tel.: (812) 596-85-49 Russian Federation

T. E. Poroshina

N.N. Petrov Research Institute of Oncology, St. Petersburg, Russian Federation

Email: levmb@endocrin.spb.ru
Physician of Clinical and Laboratory Diagnostics, Laboratory of Endocrinology, Research Institute of Oncology named after N.N. Petrov Address: 197758, St. Petersburg, Pesochnyi Village, Leningradskaya St., 68; tel.: (812) 596-85-49 Russian Federation

M. P. Boyarkina

N.N. Petrov Research Institute of Oncology, St. Petersburg, Russian Federation

Email: bomari@list.ru
Endocrinologist, Laboratory of Endocrinology, Research Institute of Oncology named after N.N. Petrov Address: 197758, St. Petersburg, Pesochnyi Village, Leningradskaya St., 68; tel.: (812) 596-85-49 Russian Federation

E. V. Tsyrlina

N.N. Petrov Research Institute of Oncology, St. Petersburg, Russian Federation

Email: evg.tsyrlina@gmail.com
PhD, Leading Research Worker, Laboratory of Endocrinology, Research Institute of Oncology named after N.N. Petrov Address: 197758, St. Petersburg, Pesochnyi Village, Leningradskaya St., 68; tel.: (812) 596-85-49 Russian Federation

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