IMMUNOGENETIC ASPECTS ОF EARLY RHEUMATOID ARTHRITIS

Cover Page
  • Authors: Guseva I.A.1, Demidova N.V.1, Soroka N.E.2, Novikov A.A.1, Luchikhina E.L.1, Aleksandrova E.N.1, Lukina G.V.1, Fedorenko E.V.1, Aronova E.S.1, Samarkina E.Y.1, Boldyreva M.N.3, Trofimov D.Y.2, Karateev D.E.1, Nasonov E.L.1
  • Affiliations:
    1. Research Institute of Rheumatology RAMS, Moscow, Russian Federation
    2. Joint Stock Company «DNA-Technology», Moscow, Russian Federation
    3. National Research Centre Institute of Immunology FMBA, Moscow, Russian Federation
  • Issue: Vol 68, No 4 (2013)
  • Pages: 36-43
  • Section: RHEUMATOLOGY: CURRENT ISSUES
  • URL: https://vestnikramn.spr-journal.ru/jour/article/view/194
  • DOI: https://doi.org/10.15690/vramn.v68i4.609
  • Cite item

Abstract


The study is aimed to investigate the distribution of alleles of HLA-DRB1 gene in patients with early rheumatoid arthritis and healthy individuals in Russian population, and evaluate their significance as molecular genetic markers of rheumatoid arthritis predisposition and protection. The association between alleles of HLA-DRB1 genes, antibodies to cyclic citrullinated peptides and IgM rheumatoid factor was also studied. Low and high resolution HLA-DRB1 genotyping were compared. In the cohort of patients with early rheumatoid arthritis, the alleles of HLA-DRB1 gene were found to be markers of rheumatoid arthritis protection/risk, especially in the homozygous state. They determined production of antibodies to cyclic citrullinated peptides but were not associated with rheumatoid factor IgM levels. These findings support different autoimmune mechanisms of rheumatoid arthritis pathogenesis.

 


About the authors

I. A. Guseva

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Author for correspondence.
Email: irrgus@yandex.ru

Russian Federation PhD, Senior Research Worker, Laboratory of Clinical Immunology and Molecular Biology of Rheumatic Diseases, Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 615-93-07

N. V. Demidova

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: natasha-demidova@mail.ru

Russian Federation PhD, Research Worker, Department of Early Arthritis, Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 614-42-79

N. E. Soroka

Joint Stock Company «DNA-Technology», Moscow, Russian Federation

Email: nataliyasoroka@yandex.ru

Russian Federation Research Worker of Scientific and Production Department, Research and Production Company DNA Technology. Address: 115478, Moscow, Kashirskoye Highway 2/2; tel.: (495) 980-45-55

A. A. Novikov

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: irramnlab@rambler.ru

Russian Federation PhD, Leading Research Worker, Laboratory of Clinical Immunology and Molecular Biology of Rheumatic Diseases, Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 614-09-33

E. L. Luchikhina

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: eleluch@yandex.ru

Russian Federation PhD, Leading Research Worker, Department of Early Arthritis, Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 614-42-79

E. N. Aleksandrova

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: irramnlab@rambler.ru

Russian Federation PhD, Head of the Laboratory of Clinical Immunology and Molecular Biology of Rheumatic Diseases, Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 614-09-33

G. V. Lukina

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: gvl3@yandex.ru

Russian Federation PhD, Head of the Laboratory of Clinical Pharmacology, Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 618-92-38

E. V. Fedorenko

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: ev_f@bk.ru

Russian Federation PhD, Junior Research Worker, Laboratory of Clinical Pharmacology Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 618-92-38

E. S. Aronova

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: eugpozd@mail.ru

Russian Federation PhD, Junior Research Worker, Laboratory of Clinical Pharmacology Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 618-92-38

E. Yu. Samarkina

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: samarkinale@list.ru

Russian Federation Junior Research Worker, Laboratory of Clinical Immunology and Molecular Biology of Rheumatic Diseases, Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 615-93-07

M. N. Boldyreva

National Research Centre Institute of Immunology FMBA, Moscow, Russian Federation

Email: rita@dna-technology.ru

Russian Federation PHD, Leading Research Worker, Department of Immunogenetics, Institute of Immunology. Address: 115478, Kashirskoye Highway 24/2; tel.: (499) 617-78-22

D. Yu. Trofimov

Joint Stock Company «DNA-Technology», Moscow, Russian Federation

Email: molgen@bk.ru

Russian Federation PhD, General Director of Research and Production Company DNA Technology. Address: 115478, Kashirskoye Highway 24/2; tel.: (495) 980-45-55

D. E. Karateev

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: dekar@inbox.ru

Russian Federation PhD, Head of Department of Early Arthritis, Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499)614-31-73

E. L. Nasonov

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: sokrat@irramn.ru

Russian Federation PhD, Professor, RAMS academician, Director of Research Institute of Rheumatology, Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 614-44-90

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