IMMUNOGENETIC ASPECTS ОF EARLY RHEUMATOID ARTHRITIS

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Abstract

The study is aimed to investigate the distribution of alleles of HLA-DRB1 gene in patients with early rheumatoid arthritis and healthy individuals in Russian population, and evaluate their significance as molecular genetic markers of rheumatoid arthritis predisposition and protection. The association between alleles of HLA-DRB1 genes, antibodies to cyclic citrullinated peptides and IgM rheumatoid factor was also studied. Low and high resolution HLA-DRB1 genotyping were compared. In the cohort of patients with early rheumatoid arthritis, the alleles of HLA-DRB1 gene were found to be markers of rheumatoid arthritis protection/risk, especially in the homozygous state. They determined production of antibodies to cyclic citrullinated peptides but were not associated with rheumatoid factor IgM levels. These findings support different autoimmune mechanisms of rheumatoid arthritis pathogenesis.

 

About the authors

I. A. Guseva

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Author for correspondence.
Email: irrgus@yandex.ru
PhD, Senior Research Worker, Laboratory of Clinical Immunology and Molecular Biology of Rheumatic Diseases, Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 615-93-07 Russian Federation

N. V. Demidova

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: natasha-demidova@mail.ru
PhD, Research Worker, Department of Early Arthritis, Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 614-42-79 Russian Federation

N. E. Soroka

Joint Stock Company «DNA-Technology», Moscow, Russian Federation

Email: nataliyasoroka@yandex.ru
Research Worker of Scientific and Production Department, Research and Production Company DNA Technology. Address: 115478, Moscow, Kashirskoye Highway 2/2; tel.: (495) 980-45-55 Russian Federation

A. A. Novikov

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: irramnlab@rambler.ru
PhD, Leading Research Worker, Laboratory of Clinical Immunology and Molecular Biology of Rheumatic Diseases, Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 614-09-33 Russian Federation

E. L. Luchikhina

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: eleluch@yandex.ru
PhD, Leading Research Worker, Department of Early Arthritis, Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 614-42-79 Russian Federation

E. N. Aleksandrova

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: irramnlab@rambler.ru
PhD, Head of the Laboratory of Clinical Immunology and Molecular Biology of Rheumatic Diseases, Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 614-09-33 Russian Federation

G. V. Lukina

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: gvl3@yandex.ru
PhD, Head of the Laboratory of Clinical Pharmacology, Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 618-92-38 Russian Federation

E. V. Fedorenko

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: ev_f@bk.ru
PhD, Junior Research Worker, Laboratory of Clinical Pharmacology Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 618-92-38 Russian Federation

E. S. Aronova

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: eugpozd@mail.ru
PhD, Junior Research Worker, Laboratory of Clinical Pharmacology Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 618-92-38 Russian Federation

E. Yu. Samarkina

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: samarkinale@list.ru
Junior Research Worker, Laboratory of Clinical Immunology and Molecular Biology of Rheumatic Diseases, Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 615-93-07 Russian Federation

M. N. Boldyreva

National Research Centre Institute of Immunology FMBA, Moscow, Russian Federation

Email: rita@dna-technology.ru
PHD, Leading Research Worker, Department of Immunogenetics, Institute of Immunology. Address: 115478, Kashirskoye Highway 24/2; tel.: (499) 617-78-22 Russian Federation

D. Yu. Trofimov

Joint Stock Company «DNA-Technology», Moscow, Russian Federation

Email: molgen@bk.ru
PhD, General Director of Research and Production Company DNA Technology. Address: 115478, Kashirskoye Highway 24/2; tel.: (495) 980-45-55 Russian Federation

D. E. Karateev

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: dekar@inbox.ru
PhD, Head of Department of Early Arthritis, Research Institute of Rheumatology Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499)614-31-73 Russian Federation

E. L. Nasonov

Research Institute of Rheumatology RAMS, Moscow, Russian Federation

Email: sokrat@irramn.ru
PhD, Professor, RAMS academician, Director of Research Institute of Rheumatology, Russian Academy of Medical Sciences Address: 115522, Moscow, Kashirskoye Highway, 34A; tel.: (499) 614-44-90 Russian Federation

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