Lipid, Adipokine аnd Ghrelin Concentrations in Myocardial Infarction Patients with Insulin Resistance

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  • Authors: Gruzdeva O.V.1, Karetnikova V.N.2, Akbasheva O.Е.3, Fedorova T.S.3, Belik E.V.1, Palicheva E.I.2, Uchasova E.G.1, Dyleva Y.A.1, Brazovskaya N.G.3, Barbarash O.L.2
  • Affiliations:
    1. Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation
    2. Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation Kemerovo State Medical Academy, Russian Federation
    3. Siberian State Medical University, Tomsk, Russian Federation
  • Issue: Vol 68, No 7 (2013)
  • Pages: 13-19
  • Section: CARDIOLOGY AND CARDIOVASCULAR SURGERY: CURRENT ISSUES
  • URL: https://vestnikramn.spr-journal.ru/jour/article/view/162
  • DOI: https://doi.org/10.15690/vramn.v68i7.706
  • Cite item

Abstract


Aim. The estimate insulin resistance in myocardial infarction. Patients and methods. The study involved 200 patients with myocardial infarction, in which on the 1st and 12th day of hospitalization measured glucose, insulin, insulin resistance index (IR), lipid profile, the concentration of adipokines and ghrelin. Results. IR was detected in 77% of patients and was associated with a history of factors of cardiovascular risk, adverse clinical course of the disease, lipid disorders. The most important marker was the level of free fatty acids. High risk associated with increased in 9 times the concentration of free fatty acids in blood plasma. Patients with IR observed increased concentrations of leptin, resistin, and reduced the protective effect of adiponectin. The high specificity and sensitivity characteristic of the concentration of ghrelin: its reduction by 4 times in the acute phase of myocardial infarction increases the risk of MI by 78%. Conclusions. Significant risk factors for MI myocardial infarction, along with insulinemia and glycemia, is to increase the concentration of free fatty acids and the disbalance in the system adipokines against deficiency of ghrelin in acute and early recovery periods of the disease. Free fatty acids and ghrelin are promising markers to stratify the risk of insulin resistance in patients with myocardial infarction.

 


About the authors

O. V. Gruzdeva

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation

Author for correspondence.
Email: gruzov@cardio.kem.ru

Russian Federation

PhD, Department of Diagnostics of Cardiovascular Diseases, Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
Address: 650002, Kemerovo, Sosnovy Blvd., 6; tel.: (3842) 64-05-53

V. N. Karetnikova

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation
Kemerovo State Medical Academy, Russian Federation

Email: tori1071@mail.ru

Russian Federation PhD, Head of the Laboratory of Blood Circulation Pathology of Multifocal Atherosclerosis, Department of Multifocal Atherosclerosis Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS, Professor, Department of Cardiology and Cardiovascular Surgery, Kemerovo State Medical
Address: 650002, Kemerovo, Sosnovy Blvd., 6; tel.: (3842) 64-05-53

O. Е. Akbasheva

Siberian State Medical University, Tomsk, Russian Federation

Email: akbashoe@yandex.ru

Russian Federation

PhD, Associate Professor, Department of Biochemistry, Siberian State Medical University Address: 634050, Tomsk, Moscow path, 6; tel.: (3822) 42-09-22

T. S. Fedorova

Siberian State Medical University, Tomsk, Russian Federation

Email: akbashoe@yandex.ru

Russian Federation

PhD, Associate Professor, Department of Biochemistry, Siberian State Medical University. Address: 634050, Tomsk, Moscow path, 6; tel.: (3822) 42-09-22

E. V. Belik

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation

Email: sionina.ev@mail.ru

Russian Federation

Junior Research Worker, Department of Diagnostics of Cardiovascular Diseases, Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
Address: 650002, Kemerovo, Sosnovy Blvd., 6; tel.: (3842) 64-05-53

E. I. Palicheva

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation
Kemerovo State Medical Academy, Russian Federation

Email: palichevaelena@rambler.ru

Russian Federation

PhD, Senior Research Worker, Department of Diagnostics of Cardiovascular Diseases, Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS, Associate Professor, Department of Biochemistry, Kemerovo State Medical Academy
Address: 650002, Kemerovo, Sosnovy Blvd., 6; tel.: (3842) 64-05-53

E. G. Uchasova

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation

Email: uchaeg@cardio.kem.ru

Russian Federation PhD, Senior Research Worker, Department of Diagnostics of Cardiovascular Diseases, Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
Address: 650002, Kemerovo, Sosnovy Blvd., 6; tel.: (3842) 64-05-53

Yu. A. Dyleva

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation

Email: dileya@cardio.kem.ru

Russian Federation

Junior Research Worker, Department of Diagnostics of Cardiovascular Diseases, Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
Address: 650002, Kemerovo, Sosnovy Blvd., 6; tel.: (3842) 64-05-53

N. G. Brazovskaya

Siberian State Medical University, Tomsk, Russian Federation

Email: brand@mail.ru

Russian Federation PhD, Senior Lecturer, Department of Medical and Biological Cybernetics, Siberian State Medical University
Address: 634050, Tomsk, Moscow path, 6; tel.: (3822) 42-09-22

O. L. Barbarash

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation
Kemerovo State Medical Academy, Russian Federation

Email: barbol@cardio.kem.ru

Russian Federation

PhD, Professor, Director of the Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS, Head of Multifocal Atherosclerosis Department Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS, Head of the Department of Cardiology and Cardiovascular Surgery, Kemerovo State Medical Academy
Address: 650002, Kemerovo, Sosnovy Blvd., 6; tel.: (3842) 64-33-08

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