NANOPARTICLES AS DRUG DELIVERY SYSTEM FOR ANTITUBERCULOUS DRUGS

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Abstract

The increase of tuberculosis incidence in last decade stimulated elaboration of both new antituberculous drugs and also searches of optimizing delivery systems for existing drugs. It is determined by their side effects and low bioavailability of effective first line  drug rifampicin. Various nanosystems for transport of antituberculous drugs are considered on the basis of various polymers, liposomes, lipid nanoparticles, nanoemulsios, nanosuspensions, dendrimers, cyclodextrines. Influence of drug incorporation into nanoparticles, most often for rifampicin, on pharmacokinetics and efficiency in tuberculosis models is discussed. The most of works are devoted to polymer nanoparticles for oral administration where increased circulation time and efficiency were shown. The best results were observed after drug inclusion into solid lipid nanoparticles. The liposomes formulations were investigated mostly for inhalation and injection administrations. Positive results were also observed. Authors underline the viability of incorporation of antituberculous drugs into phospholipid nanoparticles that may increase intestinal absorption and bioavailability. It is confirmed by authors’ own data that showed increase of rifampicin efficiency after their incorporation into such nanoparticles.

 

About the authors

M. A. Sanzhakov

Institute of Biomedical Chemistry, RAMS, Moscow, Russian Federation

Author for correspondence.
Email: iamaks@rambler.ru
research scientist of the Laboratory of Phospholipid Nanomedicines and Transport Systems, Institute of Biomedical Chemistry of RAMS. Address: 119121, Moscow, Pogodinskaya Street, 10; tel.: (495) 708-38-07 Россия

O. M. Ipatova

Institute of Biomedical Chemistry, RAMS, Moscow, Russian Federation

Email: ipatova@ibmc.msk.ru
PhD, Head of Department of Nanomedicines, Institute of Biomedical Chemistry of RAMS. Address: 119121, Moscow, Pogodinskaya Street, 10; tel.: (499) 246-40-08 Россия

T. I. Torkhovskaya

Institute of Biomedical Chemistry, RAMS, Moscow, Russian Federation

Email: torti@mail.ru
PhD, leading research scientist of the Laboratory of Phospholipid Nanomedicines and Transport Systems, Institute of Biomedical Chemistry of RAMS. Address: 119121, Moscow, Pogodinskaya Street, 10; tel.: (499) 248-40-08, (499) 246-43-56 Россия

V. N. Prozorovskii

Institute of Biomedical Chemistry, RAMS, Moscow, Russian Federation

Email: vladimir.prozorovskiy@ibmc.msk.ru
PhD, chief research scientist of the Laboratory of Phospholipid Nanomedicines and Transport Systems, Institute of Biomedical Chemistry of RAMS. Address: 119121, Moscow, Pogodinskaya Street, 10; tel.: (495) 708-38-07 Россия

E. G. Tikhonova

Institute of Biomedical Chemistry, RAMS, Moscow, Russian Federation

Email: elena.tikhonova@ibmc.msk.ru
MD, leading research scientist of the Laboratory of Phospholipid Nanomedicines and Transport Systems, Institute of Biomedical Chemistry of RAMS. Address: 119121, Moscow, Pogodinskaya Street, 10; tel.: (499) 246-36-31 Россия

O. S. Druzhilovskaya

Institute of Biomedical Chemistry, RAMS, Moscow, Russian Federation

Email: strekalova.oksana@ibmc.msk.ru
MD, research scientist of the Laboratory of Phospholipid Nanomedicines and Transport Systems, Institute of Biomedical Chemistry of RAMS. Address: 119121, Moscow, Pogodinskaya Street, 10; tel.: (499) 246-36-31 Россия

N. V. Medvedeva

Institute of Biomedical Chemistry, RAMS, Moscow, Russian Federation

Email: nmedvedeva@ibmc.msk.ru
MD, leading research scientist of the Laboratory of Phospholipid Nanomedicines and Transport Systems, Institute of Biomedical Chemistry of RAMS. Address: 119121, Moscow, Pogodinskaya Street, 10; tel.: (495) 708-38-07 Россия

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