НАНОЧАСТИЦЫ КАК СИСТЕМЫ ТРАНСПОРТА ДЛЯ ПРОТИВОТУБЕРКУЛЕЗНЫХ ЛЕКАРСТВ

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Аннотация

Повышение частоты заболеваемости туберкулезом в последние годы стимулировало разработки новых противотуберкулезных препаратов, а также способов повышения эффективности уже имеющихся средств с использованием различных систем транспорта.  Это обусловлено побочными реакциями и низкой биодоступностью одного из наиболее эффективных противотуберкулезных препаратов 1-го ряда рифампицина. В обзоре рассмотрены различные системы транспорта противотуберкулезных препаратов на основе полимеров, липосом, липидных наночастиц, дендримеров, циклодекстринов, наноэмульсий. Приведены данные по влиянию включения лекарств (чаще всего — рифампицина) в наночастицы на их фармакокинетику и противотуберкулезную активность. Наибольшее число работ посвящено полимерным наночастицам, вводимым перорально: показано увеличение времени циркуляции и активности включенных противотуберкулезных препаратов. Более высокая эффективность наблюдалась при использовании твердых липидных наночастиц. Для ингаляционного или инъекционного введения исследовали в большей степени влияние липосомальных форм, также показавших положительные результаты. Отмечена перспективность встраивания противотуберкулезных препаратов в наночастицы на основе фосфолипидов, и приведены собственные данные авторов о повышении эффективности рифампицина при встраивании в такие наночастицы.

 

Об авторах

М. А. Санжаков

Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича РАМН, Москва, Российская Федерация

Автор, ответственный за переписку.
Email: iamaks@rambler.ru
research scientist of the Laboratory of Phospholipid Nanomedicines and Transport Systems, Institute of Biomedical Chemistry of RAMS. Address: 119121, Moscow, Pogodinskaya Street, 10; tel.: (495) 708-38-07 Россия

О. М. Ипатова

Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича РАМН, Москва, Российская Федерация

Email: ipatova@ibmc.msk.ru
PhD, Head of Department of Nanomedicines, Institute of Biomedical Chemistry of RAMS. Address: 119121, Moscow, Pogodinskaya Street, 10; tel.: (499) 246-40-08 Россия

Т. И. Торховская

Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича РАМН, Москва, Российская Федерация

Email: torti@mail.ru
PhD, leading research scientist of the Laboratory of Phospholipid Nanomedicines and Transport Systems, Institute of Biomedical Chemistry of RAMS. Address: 119121, Moscow, Pogodinskaya Street, 10; tel.: (499) 248-40-08, (499) 246-43-56 Россия

В. Н. Прозоровский

Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича РАМН, Москва, Российская Федерация

Email: vladimir.prozorovskiy@ibmc.msk.ru
PhD, chief research scientist of the Laboratory of Phospholipid Nanomedicines and Transport Systems, Institute of Biomedical Chemistry of RAMS. Address: 119121, Moscow, Pogodinskaya Street, 10; tel.: (495) 708-38-07 Россия

Е. Г. Тихонова

Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича РАМН, Москва, Российская Федерация

Email: elena.tikhonova@ibmc.msk.ru
MD, leading research scientist of the Laboratory of Phospholipid Nanomedicines and Transport Systems, Institute of Biomedical Chemistry of RAMS. Address: 119121, Moscow, Pogodinskaya Street, 10; tel.: (499) 246-36-31 Россия

О. С. Дружиловская

Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича РАМН, Москва, Российская Федерация

Email: strekalova.oksana@ibmc.msk.ru
MD, research scientist of the Laboratory of Phospholipid Nanomedicines and Transport Systems, Institute of Biomedical Chemistry of RAMS. Address: 119121, Moscow, Pogodinskaya Street, 10; tel.: (499) 246-36-31 Россия

Н. В. Медведева

Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича РАМН, Москва, Российская Федерация

Email: nmedvedeva@ibmc.msk.ru
MD, leading research scientist of the Laboratory of Phospholipid Nanomedicines and Transport Systems, Institute of Biomedical Chemistry of RAMS. Address: 119121, Moscow, Pogodinskaya Street, 10; tel.: (495) 708-38-07 Россия

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