RESULTS AND PROSPECTS OF INTERFERONE INDUCERS USING IN INFECTIOUS DISEASES TREATMENT

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  • Authors: Ershov F.I.1, Shul'dyakov A.A.2, Romantsov M.G.3, Lyapina E.P.4, Soboleva L.A.2
  • Affiliations:
    1. Research Institute N.F. Gamaley, Moscow, Russian Federation
    2. Saratov State Medical University V.I. Razumovsky, Russian Federation
    3. North- West Medical University I.I. Mechnikov, St. Petersburg, Russian Federation
    4. Saratov State Medical University V.I. Razumovsky, Russian Federation Saratov Research Institute of Rural Hygiene, Russian Federation
  • Issue: Vol 68, No 10 (2013)
  • Pages: 46-52
  • Section: SHORT MESSAGES
  • URL: https://vestnikramn.spr-journal.ru/jour/article/view/139
  • DOI: https://doi.org/10.15690/vramn.v68i10.788
  • Cite item

Abstract


There is represented  the current classification of interferon inducers of various chemical groups related to antiviral agents, described the mechanisms of synthesis of different types of endogenous interferon in blood serum. The effectiveness of methylglucamine acridonacetates  in integrated treatment of chronic hepatitis C, tuberculosis with  HIV infection background, chronic brucellosis, arboviral diseases, including West Nile fever , as well as influenza and acute respiratory infections are shown.  For successful treatment of acute and chronic diseases with  endogenous interferon inducers should be applied as early as possible, at an average level of viremia , to enhance the effect of drugs with the directed etiotropic action and immunomodulators , which achieves the optimal pharmacotherapeutic effect.



F. I. Ershov

Research Institute N.F. Gamaley, Moscow, Russian Federation

Author for correspondence.
Email: lmn_son@rambler.ru

Russian Federation professor, PhD, member of RAMS, Head of the interferon department of the Federal State Institution of Science “N.F. Gamalei Research Institute of Epidemiology and Microbiology”. Address: 18, Gamalei St., Moscow, 123098

A. A. Shul'dyakov

Saratov State Medical University V.I. Razumovsky, Russian Federation

Email: Shuldaykov@mail.ru

Russian Federation professor, PhD, Head of the infectious diseases department of the State-funded Educational Institution of Higher Professional Education “V. I. Razumovskii Saratov State Medical University” of the Ministry of Health of the Russian Federation. Address: 112, Bol’shaya Kazach’ya St., Saratov, 410012

M. G. Romantsov

North- West Medical University I.I. Mechnikov, St. Petersburg, Russian Federation

Email: mr812@bk.ru

Russian Federation PhD, professor of the pediatrics and pediatric cardiology department of the State-funded Educational Institution of Higher Professional Education “I.I. Mechnikov North-Western State Medical University” Address: 41, Kirochnaya St., Saint-Petersburg, 191015; tel.: (812) 379-39-46

E. P. Lyapina

Saratov State Medical University V.I. Razumovsky, Russian Federation
Saratov Research Institute of Rural Hygiene, Russian Federation

Email: lmn_son@rambler.ru

Russian Federation professor, PhD, professor of the infectious diseases department of the State-funded Educational Institution of Higher Professional Education “V. I. Razumovskii Saratov State Medical University” of the Ministry of Health of the Russian Federation. Address: 112, Bol’shaya Kazach’ya Saratov, 410012

L. A. Soboleva

Saratov State Medical University V.I. Razumovsky, Russian Federation

Email: milas73@mail.ru

Russian Federation associate professor, MD, associate professor of the therapeutic dentistry department of the State-funded Educational Institution of Higher Professional Education “V. I. Razumovskii Saratov State Medical University” of the Ministry of Health of the Russian Federation. Address: 112, Bol’shaya Kazach’ya Saratov, 410012

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