RESULTS AND PROSPECTS OF INTERFERONE INDUCERS USING IN INFECTIOUS DISEASES TREATMENT

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Abstract

There is represented  the current classification of interferon inducers of various chemical groups related to antiviral agents, described the mechanisms of synthesis of different types of endogenous interferon in blood serum. The effectiveness of methylglucamine acridonacetates  in integrated treatment of chronic hepatitis C, tuberculosis with  HIV infection background, chronic brucellosis, arboviral diseases, including West Nile fever , as well as influenza and acute respiratory infections are shown.  For successful treatment of acute and chronic diseases with  endogenous interferon inducers should be applied as early as possible, at an average level of viremia , to enhance the effect of drugs with the directed etiotropic action and immunomodulators , which achieves the optimal pharmacotherapeutic effect.


About the authors

F. I. Ershov

Research Institute N.F. Gamaley, Moscow, Russian Federation

Author for correspondence.
Email: lmn_son@rambler.ru
professor, PhD, member of RAMS, Head of the interferon department of the Federal State Institution of Science “N.F. Gamalei Research Institute of Epidemiology and Microbiology”. Address: 18, Gamalei St., Moscow, 123098 Россия

A. A. Shul'dyakov

Saratov State Medical University V.I. Razumovsky, Russian Federation

Email: Shuldaykov@mail.ru
professor, PhD, Head of the infectious diseases department of the State-funded Educational Institution of Higher Professional Education “V. I. Razumovskii Saratov State Medical University” of the Ministry of Health of the Russian Federation. Address: 112, Bol’shaya Kazach’ya St., Saratov, 410012 Россия

M. G. Romantsov

North- West Medical University I.I. Mechnikov, St. Petersburg, Russian Federation

Email: mr812@bk.ru
PhD, professor of the pediatrics and pediatric cardiology department of the State-funded Educational Institution of Higher Professional Education “I.I. Mechnikov North-Western State Medical University” Address: 41, Kirochnaya St., Saint-Petersburg, 191015; tel.: (812) 379-39-46 Россия

E. P. Lyapina

Saratov State Medical University V.I. Razumovsky, Russian Federation
Saratov Research Institute of Rural Hygiene, Russian Federation

Email: lmn_son@rambler.ru
professor, PhD, professor of the infectious diseases department of the State-funded Educational Institution of Higher Professional Education “V. I. Razumovskii Saratov State Medical University” of the Ministry of Health of the Russian Federation. Address: 112, Bol’shaya Kazach’ya Saratov, 410012 Россия

L. A. Soboleva

Saratov State Medical University V.I. Razumovsky, Russian Federation

Email: milas73@mail.ru
associate professor, MD, associate professor of the therapeutic dentistry department of the State-funded Educational Institution of Higher Professional Education “V. I. Razumovskii Saratov State Medical University” of the Ministry of Health of the Russian Federation. Address: 112, Bol’shaya Kazach’ya Saratov, 410012 Россия

References

  1. Grigoryan S.S. Induktory interferona: itogi i perspektivy. V knige: Interferonu — 50 let. Yubileinii sbornik, posvyashchennyi otkrytiyu interferonov. [Interferon Inductors: Results and Perspectives. In the book: 50 Years of Interferon. Anniversary Volume Devoted to Interferon Discovery. Edited by Ershov F.I.]. Мoscow, 2007. pp. 66–71.
  2. Ershov F.I., Narovlyanskii A.N. Osnovnye itogi izucheniya sistemy interferona k 2011 godu. V knige: Interferon. Sbornik nauchnykh statei. [Main Results of Interferon System Study to 2011. In the book: Interferon. Collection of Scientific Articles]. Мoscow, 2012. pp. 14–34.
  3. Romantsov M.G., Ershov F.I. Immunnyi otvet pri virusnykh infektsiyakh. V knige: Chasto boleyushchie deti: sovremennaya farmakoterapiya. [Immune Response to Viral Infections. In the book: RRI children: Contemporary Pharmacotherapy]. Мoscow, 2009. pp. 134–142.
  4. Tazulakhova E.B. Induktsiya i produktsiya interferonov. V knige: Sistema interferona v norme i patologii. [Induction and Production of Interferons. In the book: The Interferon System under Normal and Pathological Conditions. Ed. Ershov F.I.]. Мoscow, 1996. pp. 71–87.
  5. Sokolova Т.М. Immunnoe uznavanie virusnykh nukleinovykh kislot privodit k induktsii interferonov i vospalitelnykh tsitokinov. V knige: Interferon. Sbornik nauchnykh statey. [Immune Recognition of Viral Nucleic Acids Leads to Induction of Interferon and Inflammatory Cytokines. In the book: Interferon. Collection of Scientific Articles]. Мoscow, 2011. pp. 52–62.
  6. Bazhenova E.D. Eksperimental’naya i klinicheskaya farmakologiya = Experimental and Clinical Pharmacology. 2012; 7: 40–44.
  7. Ershov F.I., Tazulakhova E.B. Ot chego zavisyat effekty induktorov interferona? V knige: Interferon. Sbornik nauchnykh statey. [What Do Effects of Interferon Inductors Depends on? In the book: Interferon. Collection of Scientific Articles]. Мoscow, 2012. pp. 80–106.
  8. Ershov F.I., Kiselev O.I. Induktory interferona kak antivirusnye preparaty etiotropnogo deistviya. Interferony i ikh induktory (ot molekul do lekarstv). [Interferon Inductors as Etiotropic-Acting Antiviral Drugs. Interferons and Their Inductors (from Molecules to Drugs]. Мoscow, 2005. pp. 211–220.
  9. Yushchuk N.D., Bokova N.O., Znoiko O.O. Lechashhii vrach - Practicing Doctor. 2012; 10: 64–67.
  10. Petrova А.G. Poliklinika = Polyclinic. 2012; 8: 58–59.
  11. Lazutkina E.L., Lazarenko L.L., Landyshev Yu.S. Novosti khirurgii = Surgery News. 2012; 43: 23–27.
  12. Ershov F.I., Kovalenko A.L., Romantsov M.G. Eksperimental’naya i klinicheskaya farmakologiya – Experimental and Clinical Pharmacology. 2011; 6: 41–45.
  13. Ershov F.I., Romantsov M.G. Virusnye gepatity. V knige: Antivirusnye sredstva v pediatrii. [Viral Hepatitis. In the book: Virus Inactivating Agents in Pediatrics]. Мoscow, 2005. pp. 179–194.
  14. Sologub T.V., Shuldyakov A.A., Goryacheva L.G. Antibiotiki i khimioterapiya = Antibiotics and Chemotherapy. 2011; 9: 37–41.
  15. Romantsov M.G., Sologub T.V., Goryacheva L.G. Antibiotiki i khimioterapiya = Antibiotics and Chemotherapy. 2010; 3–4: 45–54.
  16. Vasil’eva D.K., Goryacheva L.G., Monakhova N.E. Eksperimental’naya i klinicheskaya farmakologiya = Experimental and Clinical Pharmacology. 2011; 12: 33–35.
  17. Ivanov A.K., Panteleev A.M., Sukhanov D.S. Klinicheskaya meditsina = Clinical Medicine. 2010; 5: 71–76.
  18. Ivanov A.K., Sologub T.V., Panteleev A.M. Eksperimental’naya i klinicheskaya farmakologiya = Experimental and Clinical Pharmacology. 2010; 7: 32–35.
  19. Cherenov I.V., Galimzyanov Kh.M., Sologub T.V. Klinicheskaya meditsina = Clinical Medicine. 2012;4: 59–62.
  20. Sherysheva Yu.V., Galimzyanov Kh.M., Kovalenko A.L. Antibiotiki i khimioterapiya = Antibiotics and Chemotherapy. 2012; 1: 26–31.
  21. Lyapina E.P., Spirin V.F., Shul’dyakov A.A. etc. Brutsellez. Sovremennye podkhody k terapii: Posobie dlya vrachei. [Brucellosis. Modern Attempts at Therapy: Guidelines for Physicians Ed. Shul’dyakov А.А., Romantsov M.G.]. Saratov – St.Petersburg, 2006. 28 p.
  22. Stepanova L.А. Immunnyi otvet na grippoznuyu infektsiyu. V knige: Gripp: epidemiologiya, diagnostika, lechenie, profilaktika. [Immune Response to Influenza Infection. In the book: Influenza: Epidemiology, Diagnostics, Treatment, Prevention. Edited by Kiselev О.I., Tsymbalova L.М., Pokrovskii V.I.]. Мoscow, 2012. pp. 82–108.
  23. Deeva E.G., Kiselev O.I. Protivovirusnye preparaty: interferony i induktory interferonov. V knige: Gripp: epidemiologiya, diagnostika, lechenie, profilaktika. [Antiviral Drugs: Interferons and Interferon Inductors. In the book: Influenza: Epidemiology, Diagnostics, Treatment, Prevention. Edited by Kiselev О.I., Tsymbalova L.М., Pokrovskii V.I.]. Мoscow, 2012. pp. 338–345.
  24. Ershov F.I., Narovlyanskii A.N., Mezentseva M.V. Tsitokiny i vospalenie = Cytotoxicants and inflammation. 2004; 1: 3–6.
  25. Goryacheva L.G. HB-HC-virusnaya infektsiya u detey, infitsirovannykh v rannem vozraste. [HB-HC Viral Infection in Children Infected at an Early Age. Author’s abstract]. St.Petersburg, 2005. 49 p.
  26. L’vov D.K., Pisarev V.B., Petrov V.A. Grigor’eva P.V. Likhoradka Zapadnogo Nila: po materialam vspyshek v Volgogradskoi oblasti v 1999–2002 gg. [West Nile Fever: Following Outbreaks in Volgograd Region in 1999–2002]. Volgograd, 2004. 104 p.
  27. Kimirilova O.G., Nazarochkina O.V. Klinicheskaya effektivnost preparata tsikloferon pri likhoradke Zapadnogo Nila u detei [Clinical Efficacy of Cycloferon at West Nile Fever in Children]. Sbornik materialov XII Kongressa pediatrov Rossii. (Proceedings of the 12th Congress of Pediatriciansof Russia]. Мoscow,2008. 150 p.
  28. Bukharin O.V., Kirillov D.A., Sheenkov N.V., Kirillov V.A. Zhurnal mikrobiologii = Journal of Microbiology. 2005; 3: 8–10.

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