RESULTS AND PROSPECTS OF INTERFERONE INDUCERS USING IN INFECTIOUS DISEASES TREATMENT

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Abstract

There is represented  the current classification of interferon inducers of various chemical groups related to antiviral agents, described the mechanisms of synthesis of different types of endogenous interferon in blood serum. The effectiveness of methylglucamine acridonacetates  in integrated treatment of chronic hepatitis C, tuberculosis with  HIV infection background, chronic brucellosis, arboviral diseases, including West Nile fever , as well as influenza and acute respiratory infections are shown.  For successful treatment of acute and chronic diseases with  endogenous interferon inducers should be applied as early as possible, at an average level of viremia , to enhance the effect of drugs with the directed etiotropic action and immunomodulators , which achieves the optimal pharmacotherapeutic effect.


About the authors

F. I. Ershov

Research Institute N.F. Gamaley, Moscow, Russian Federation

Author for correspondence.
Email: lmn_son@rambler.ru
professor, PhD, member of RAMS, Head of the interferon department of the Federal State Institution of Science “N.F. Gamalei Research Institute of Epidemiology and Microbiology”. Address: 18, Gamalei St., Moscow, 123098 Russian Federation

A. A. Shul'dyakov

Saratov State Medical University V.I. Razumovsky, Russian Federation

Email: Shuldaykov@mail.ru
professor, PhD, Head of the infectious diseases department of the State-funded Educational Institution of Higher Professional Education “V. I. Razumovskii Saratov State Medical University” of the Ministry of Health of the Russian Federation. Address: 112, Bol’shaya Kazach’ya St., Saratov, 410012 Russian Federation

M. G. Romantsov

North- West Medical University I.I. Mechnikov, St. Petersburg, Russian Federation

Email: mr812@bk.ru
PhD, professor of the pediatrics and pediatric cardiology department of the State-funded Educational Institution of Higher Professional Education “I.I. Mechnikov North-Western State Medical University” Address: 41, Kirochnaya St., Saint-Petersburg, 191015; tel.: (812) 379-39-46 Russian Federation

E. P. Lyapina

Saratov State Medical University V.I. Razumovsky, Russian Federation
Saratov Research Institute of Rural Hygiene, Russian Federation

Email: lmn_son@rambler.ru
professor, PhD, professor of the infectious diseases department of the State-funded Educational Institution of Higher Professional Education “V. I. Razumovskii Saratov State Medical University” of the Ministry of Health of the Russian Federation. Address: 112, Bol’shaya Kazach’ya Saratov, 410012 Russian Federation

L. A. Soboleva

Saratov State Medical University V.I. Razumovsky, Russian Federation

Email: milas73@mail.ru
associate professor, MD, associate professor of the therapeutic dentistry department of the State-funded Educational Institution of Higher Professional Education “V. I. Razumovskii Saratov State Medical University” of the Ministry of Health of the Russian Federation. Address: 112, Bol’shaya Kazach’ya Saratov, 410012 Russian Federation

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