Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC13910.15690/vramn.v68i10.788SHORT MESSAGESКРАТКИЕ СООБЩЕНИЯRESULTS AND PROSPECTS OF INTERFERONE INDUCERS USING IN INFECTIOUS DISEASES TREATMENTРЕЗУЛЬТАТЫ И ПЕРСПЕКТИВЫ ИСПОЛЬЗОВАНИЯ ИНДУКТОРОВ ИНТЕРФЕРОНА В ЛЕЧЕНИИ ИНФЕКЦИОННЫХ БОЛЕЗНЕЙErshovF. I.ЕршовФ. И.
Russian Federation

professor, PhD, member of RAMS, Head of the interferon department of the Federal State Institution of Science “N.F. Gamalei Research Institute of Epidemiology and Microbiology”. Address: 18, Gamalei St., Moscow, 123098

lmn_son@rambler.ruShul'dyakovA. A.ШульдяковА. А.
Russian Federation

professor, PhD, Head of the infectious diseases department of the State-funded Educational Institution of Higher Professional Education “V. I. Razumovskii Saratov State Medical University” of the Ministry of Health of the Russian Federation. Address: 112, Bol’shaya Kazach’ya St., Saratov, 410012

Shuldaykov@mail.ruRomantsovM. G.РоманцовМ. Г.
Russian Federation

PhD, professor of the pediatrics and pediatric cardiology department of the State-funded Educational Institution of Higher Professional Education “I.I. Mechnikov North-Western State Medical University” Address: 41, Kirochnaya St., Saint-Petersburg, 191015; tel.: (812) 379-39-46

mr812@bk.ruLyapinaE. P.ЛяпинаЕ. П.
Russian Federation

professor, PhD, professor of the infectious diseases department of the State-funded Educational Institution of Higher Professional Education “V. I. Razumovskii Saratov State Medical University” of the Ministry of Health of the Russian Federation. Address: 112, Bol’shaya Kazach’ya Saratov, 410012

lmn_son@rambler.ruSobolevaL. A.СоболеваЛ. А.
Russian Federation

associate professor, MD, associate professor of the therapeutic dentistry department of the State-funded Educational Institution of Higher Professional Education “V. I. Razumovskii Saratov State Medical University” of the Ministry of Health of the Russian Federation. Address: 112, Bol’shaya Kazach’ya Saratov, 410012

milas73@mail.ruResearch Institute N.F. Gamaley, Moscow, Russian FederationНИИ ЭМ им. Н.Ф. Гамалеи, Москва, Российская ФедерацияSaratov State Medical University V.I. Razumovsky, Russian FederationСаратовский государственный медицинский университет им. В.И. Разумовского. Российская ФедерацияNorth- West Medical University I.I. Mechnikov, St. Petersburg, Russian FederationСеверо-Западный медицинский университет им. И.И. Мечникова», Санкт-Петербург, Российская ФедерацияSaratov State Medical University V.I. Razumovsky, Russian Federation Saratov Research Institute of Rural Hygiene, Russian FederationСаратовский государственный медицинский университет им. В.И. Разумовского. Российская Федерация Саратовский НИИ Сельской гигиены, Российская Федерация101020136810Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук465207082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/139

There is represented the current classification of interferon inducers of various chemical groups related to antiviral agents, described the mechanisms of synthesis of different types of endogenous interferon in blood serum. The effectiveness of methylglucamine acridonacetates in integrated treatment of chronic hepatitis C, tuberculosis with HIV infection background, chronic brucellosis, arboviral diseases, including West Nile fever , as well as influenza and acute respiratory infections are shown. For successful treatment of acute and chronic diseases with endogenous interferon inducers should be applied as early as possible, at an average level of viremia , to enhance the effect of drugs with the directed etiotropic action and immunomodulators , which achieves the optimal pharmacotherapeutic effect.

Представлена современная классификация индукторов интерферона различных химических групп, относящихся к противовирусным средствам, описаны механизмы синтеза разных типов эндогенного интерферона в сыворотке крови. Продемонстрирована эффективность метилглукамина акридонацетата в комплексном лечении хронического гепатита С, туберкулеза на фоне ВИЧ-инфекции, хронического бруцеллеза, арбовирусных заболеваний, включая лихорадку Западного Нила, а также гриппа и острых респираторных инфекций. Для успешного лечения острых и хронических заболеваний индукторы эндогенного интерферона следует применять как можно раньше, при среднем уровне виремии, для усиления эффекта препаратов направленного этиотропного действия и иммуномодуляторов, что обеспечивает достижение оптимального фармакотерапевтического эффекта.

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