Free radical reactions in socially significant infectious diseases: HIV infection, hepatitis, tuberculosis

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The analysis of current literature data on the study of the features of the course of free-radical reactions, as well as the state of the antioxidant defense system at socially significant infectious diseases — HIV infection, hepatitis, tuberculosis was carried out. The role of this kind of reaction in the genesis and progression of socially significant infections a long time has been studied. Foreign studies of recent years have been focused on the identification of specific markers of oxidative and carbonyl stress, which make it possible to identify the redox imbalance of the cell under conditions of infection and target affect it to modulate the activity of the main transcription factors of viral proteins and the bacteria pathogenicity. Numerous sources indicate the involvement of active oxygen metabolites in a wide range of events in infected cells and tissues, including neoplastic transformation processes. These biochemical markers can be used as additional criteria for monitoring the progression of infection. At the same time, noticeable gaps in this area there are that may become the goal of future research. The issues of changing free radical reactions depending on gender, age, place of residence of patients remain practically unstudied. There is little data about intensity of oxidative stress in patients of reproductive age with HIV, hepatitis B and C, and pulmonary tuberculosis, as well as the relationship of antioxidant deficiency with reproductive disorders in conditions of infection. These data could serve as the basis for the development of pathogenetically substantiated methods for the correction of socially significant infectious diseases. Modulation of the production of reactive oxygen metabolites and oxidative stress is a potentially new pharmacological approach to reduce the effects of viral and bacterial exposure.

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About the authors

Marina A. Darenskaya

Scientific Centre for Family Health and Human Reproduction Problems

Author for correspondence.
ORCID iD: 0000-0003-3255-2013
SPIN-code: 3327-4213

Russian Federation, 16 Timiryazeva str., 664003, Irkutsk


Lubov I. Kolesnikova

Scientific Centre for Family Health and Human Reproduction Problems

ORCID iD: 0000-0003-3354-2992
SPIN-code: 1584-0281

Russian Federation, Irkutsk

MD, PhD, Professor

Sergey I. Kolesnikov

Scientific Centre for Family Health and Human Reproduction Problems

ORCID iD: 0000-0003-2124-6328
SPIN-code: 1752-6695

Russian Federation, Irkutsk

MD, PhD, Professor


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