Brown adipose tissue: features of biology, participation in energy metabolism and obesity (literature review)

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Abstract


Obesity is one of the most common diseases, the proportion of which is increasing annually today in Russia. Not only adults but also adolescents and children are at risk. Excessive body weight leads to the development of metabolic syndrome and related complications — diseases of the circulatory, musculoskeletal, immune and other systems, to premature aging of the human body. Until this disease has become an epidemic, researchers around the world are trying to find methods to combat it. For these purposes, various types of adipose tissue in the human body, their importance, morphology and biology, the possibility of further use of the results to solve this problem are comprehensively studied.

The article provides an overview of current data on the morphological features of white, brown and beige adipose tissue at the tissue and cellular levels. The importance of specific proteins for the detection of different types of human adipose tissue is described. The biology and physiology of brown adipose tissue, which is of great importance in the implementation of various metabolic processes in the organism, is characterized. The need for further study of the role of brown adipose tissue for its possible promising use in the treatment of obesity is shown.


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About the authors

Liubov N. Afanaskina

Krasnoyarsk State Medical University Named after Professor V.F. Voyno-Yasenetsky

Author for correspondence.
Email: afanln@mail.ru
ORCID iD: 0000-0003-4726-3599
SPIN-code: 9239-2428

Russian Federation, 1, P. Zeleznyak street, Krasnoyarsk, 660022

PhD candidate of biological sciences, Docent of the Department of biology and ecology

Svetlana N. Derevtsova

Krasnoyarsk State Medical University Named after Professor V.F. Voyno-Yasenetsky

Email: Derevzova@bk.ru
ORCID iD: 0000-0003-2974-5930
SPIN-code: 6525-4040

Russian Federation, 1, P. Zeleznyak street, Krasnoyarsk, 660022

MD doctor of medicine, Professor of the Department of human anatomy and histology

Lyudmila V. Sindeeva

Krasnoyarsk State Medical University Named after Professor V.F. Voyno-Yasenetsky

Email: lsind@mail.ru
ORCID iD: 0000-0003-0469-9552
SPIN-code: 9456-5564

Russian Federation, 1, P. Zeleznyak street, Krasnoyarsk, 660022

MD doctor of medicine, Professor of the Department of human anatomy and histology

Elena A. Hapilina

Krasnoyarsk State Medical University Named after Professor V.F. Voyno-Yasenetsky

Email: hapilina_elena@mail.ru
ORCID iD: 0000-0002-4898-5123
SPIN-code: 6233-8154

Russian Federation, 1, P. Zeleznyak street, Krasnoyarsk, 660022

PhD candidate of medical sciences, Docent of the Department of human anatomy and histology

Nadezhda N. Medvedeva

Krasnoyarsk State Medical University Named after Professor V.F. Voyno-Yasenetsky

Email: medvenad@mail.ru
ORCID iD: 0000-0002-7757-6628
SPIN-code: 6144-1780

Russian Federation, 1, P. Zeleznyak street, Krasnoyarsk, 660022

MD doctor of medicine, Professor, the Head of the Department of anatomy and histology

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