THE EVALUATION NEUROPSYCHOLOGICAL DEVELOPMENT IN PRETERM INFANTS WITH HYPOXIC BRAIN INJURY

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Abstract


We observed 164 preterm newborns with moderate and severe hypoxic brain injury and 25 healthy newborns, who were included into control group. The clinical, laboratory and diagnostic data were analyzed and determined levels of neurospecific enolase in serum, levels of vascular endothelial growth factor in serum and levels of brain-derived neurotrophic factor in serum during the neonatal period followed with assessment of mental development by the method of Zhurba in the control time. Revealed that additional predictors of adverse mental outcomes in preterm newborns with severe hypoxic brain injury under one year were the intrauterine growth hypotrophic of III level type, the high level of neurospecific enolase in serum and low level of vascular endothelial growth factor in serum in 1 month after delivery.

 


I. V. Mikhalenko

Siberian State Medical University, Tomsk, Russian Federation

Author for correspondence.
Email: mihalenko.irina@yandex.ru

Russian Federation postgraduate of the Department of Pediatrics of Advanced Training and Occupational Retraining Faculty of SSMU. Address: 2, Moscow tract, Tomsk, RF, 634050, tel.: +7 (3822) 53-23-04

E. V. Mikhalev

Siberian State Medical University, Tomsk, Russian Federation

Email: mikhalev-ev@yandex.ru

Russian Federation PhD, professor, Head of the Department of Pediatrics of Advanced Training and Occupational Retraining Faculty of SSMU. Address: 2, Moscow tract, Tomsk, RF, 634050, tel.: +7 (3822) 53-23-04

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