THE EVALUATION NEUROPSYCHOLOGICAL DEVELOPMENT IN PRETERM INFANTS WITH HYPOXIC BRAIN INJURY

Cover Page


Cite item

Full Text

Abstract

We observed 164 preterm newborns with moderate and severe hypoxic brain injury and 25 healthy newborns, who were included into control group. The clinical, laboratory and diagnostic data were analyzed and determined levels of neurospecific enolase in serum, levels of vascular endothelial growth factor in serum and levels of brain-derived neurotrophic factor in serum during the neonatal period followed with assessment of mental development by the method of Zhurba in the control time. Revealed that additional predictors of adverse mental outcomes in preterm newborns with severe hypoxic brain injury under one year were the intrauterine growth hypotrophic of III level type, the high level of neurospecific enolase in serum and low level of vascular endothelial growth factor in serum in 1 month after delivery.

 

About the authors

I. V. Mikhalenko

Siberian State Medical University, Tomsk, Russian Federation

Author for correspondence.
Email: mihalenko.irina@yandex.ru
postgraduate of the Department of Pediatrics of Advanced Training and Occupational Retraining Faculty of SSMU. Address: 2, Moscow tract, Tomsk, RF, 634050, tel.: +7 (3822) 53-23-04 Россия

E. V. Mikhalev

Siberian State Medical University, Tomsk, Russian Federation

Email: mikhalev-ev@yandex.ru
PhD, professor, Head of the Department of Pediatrics of Advanced Training and Occupational Retraining Faculty of SSMU. Address: 2, Moscow tract, Tomsk, RF, 634050, tel.: +7 (3822) 53-23-04 Россия

References

  1. Volodin N.N. Perinatal Neurology - problems and solutions. Zhurn. nevrol. i psikhiatr = Journal of neuropathology and psychiatry. 2009; 10: 4–8.
  2. Barashnev Yu.I. Perinatal'naya nevrologiya [Perinatal Neurology]. Moscow, Triada-X, 2001. 640 p.
  3. Ogorodova L.M., Belevskii A.S., Kulikov E.S. et al.
  4. Comparative effectiveness of strategies to achieve control in clinical practice: a multicenter study data boom. Pul'monologiya = Pulmonology. 2009; 6: 69–77.
  5. Diagrammy rosta dlya nedonoshennykh detei. Korolevskii kolledzh pediatrii i detskogo zdorov'ya Velikobritanii (Growth Charts of Prematures. Royal College of Pediatrics and Child Health of the United Kingdom). 2009. Available at: http://www.rcpch.ac.uk/child-ealth/research-projects/uk-who-growth-charts-early-years/uk-who-0-4-years-growth-charts-initi (Accessed 12 July 2013)
  6. Zhurba L.T., Mastyukova E.M. Narushenie psikhomotornogo razvitiya detei pervogo goda zhizni [Impaired Psychomotor Development in Infants]. Moscow, Meditsina, 1981. 272 p.
  7. Rumyantsev A.G., Dem'yanova T.G., Grigor'yants L.Ya. etc. Nablyudenie za glubokonedonoshennymi det'mi na pervom godu zhizni [Disorder of Psychomotor Development of Children during the First Year of Life]. Moscow, MEDPRAKTIKA, 2006. 148 p.
  8. Popova Yu.Yu., Zhelev V.A., Mikhalev E.V. Feature neurospecific markers in extremely premature infants with hypoxic central nervous system. Sib. med. zhurn = Siberian medical journal. 2007; 4: 5–10.
  9. Tsutsumi Y., Losordo D.W. Double face of VEGF. Circulation. 2005; 112: 1248–1250.
  10. Golosnaya G.S. Neirokhimicheskie aspekty patogeneza gipoksicheskikh porazhenii mozga u novorozhdennykh [Neurochemical indicators of Pathogenesis of Hypoxic Brain Disorder in Newborns]. Moscow, MEDPRAKTIKA-M, 2009. 128 p.
  11. Zhang Y., Partridge W.M. Neuroprotection in transient focal brain ishemia after delayed intravenous administration of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targeting system. Stroke. 2001; 32: 1378–1384.
  12. Malamitsi-Puchner A., Economous E., Rigopoulou O., Boutsikou T. Perinatal changes of brain-derived neurotrophic factor in pre- and full term neonates. Early Hum. Dev. 2004; 76: 17–22.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 1970 "Paediatrician" Publishers LLC



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies