CENTRAL MOTOR PATHWAYS IN CHILDREN WITH MULTIPLE SCLEROSIS

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Abstract

Aim: to evaluate motor pathways involvement in children with multiple sclerosis. Patients and methods: we used transcranial magnetic stimulation method. 9 children with relapsing-remitting multiple sclerosis (mean duration 1,68 years) and 20 controls were enrolled. Results: in most of the cases findings in multiple sclerosis group were abnormal. More often polyphasic changes of the motor evoked potentials (MEP) shape (78% of the cases) and elevation of MEP threshold (88%) were seen. Conclusions: transcranial magnetic stimulation demonstrated high sensitivity in children with multiple sclerosis. Main neurophysiologic findings in multiple sclerosis in children may reflect altering membrane excitability of motor neurons and demyelinating lesions. Axonal damage in children with multiple sclerosis are less apparent.

 

About the authors

V. B. Voitenkov

Scientific and Research Institute of Children's Infections of FMBA of Russia, Saint-Petersburg, Russian Federation

Author for correspondence.
Email: vlad203@inbox.ru
MD, Head of the Department of Functional methods of diagnosis of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 234-38-23 Russian Federation

V. N. Komantsev

Scientific and Research Institute of Children's Infections of FMBA of Russia, Saint-Petersburg, Russian Federation

Email: emgep@mail.ru
PhD, Head of the Department of Functional methods of diagnosis and Imaging technologies of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 234-38-23 Russian Federation

N. V. Skripchenko

Scientific and Research Institute of Children's Infections of FMBA of Russia, Saint-Petersburg, Russian Federation

Email: niidi@niidi.ru
PhD, professor, Deputy director for Scientific Research of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 347-48-58 Russian Federation

G. P. Ivanova

Scientific and Research Institute of Children's Infections of FMBA of Russia, Saint-Petersburg, Russian Federation

Email: gpivanova@mail.ru
PhD, senior research scientist of the Department of Neuroinfections and organic lesion of central nervous system of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 347-48-58 Russian Federation

A. V. Surovtseva

Scientific and Research Institute of Children's Infections of FMBA of Russia, Saint-Petersburg, Russian Federation

Email: annasurovcev@mail.ru
postgraduate of the Department of Neuroinfections and organic lesion of central nervous system of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 234-38-23 Russian Federation

A. V. Klimkin

Scientific and Research Institute of Children's Infections of FMBA of Russia, Saint-Petersburg, Russian Federation

Email: klinkinpark@mail.ru
junior research scientist of the Department of Functional methods of diagnosis and Imaging technologies of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 234-38-23 Russian Federation

References

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