CENTRAL MOTOR PATHWAYS IN CHILDREN WITH MULTIPLE SCLEROSIS

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Abstract


Aim: to evaluate motor pathways involvement in children with multiple sclerosis. Patients and methods: we used transcranial magnetic stimulation method. 9 children with relapsing-remitting multiple sclerosis (mean duration 1,68 years) and 20 controls were enrolled. Results: in most of the cases findings in multiple sclerosis group were abnormal. More often polyphasic changes of the motor evoked potentials (MEP) shape (78% of the cases) and elevation of MEP threshold (88%) were seen. Conclusions: transcranial magnetic stimulation demonstrated high sensitivity in children with multiple sclerosis. Main neurophysiologic findings in multiple sclerosis in children may reflect altering membrane excitability of motor neurons and demyelinating lesions. Axonal damage in children with multiple sclerosis are less apparent.

 


V. B. Voitenkov

Scientific and Research Institute of Children's Infections of FMBA of Russia, Saint-Petersburg, Russian Federation

Author for correspondence.
Email: vlad203@inbox.ru

Russian Federation MD, Head of the Department of Functional methods of diagnosis of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 234-38-23

V. N. Komantsev

Scientific and Research Institute of Children's Infections of FMBA of Russia, Saint-Petersburg, Russian Federation

Email: emgep@mail.ru

Russian Federation PhD, Head of the Department of Functional methods of diagnosis and Imaging technologies of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 234-38-23

N. V. Skripchenko

Scientific and Research Institute of Children's Infections of FMBA of Russia, Saint-Petersburg, Russian Federation

Email: niidi@niidi.ru

Russian Federation PhD, professor, Deputy director for Scientific Research of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 347-48-58

G. P. Ivanova

Scientific and Research Institute of Children's Infections of FMBA of Russia, Saint-Petersburg, Russian Federation

Email: gpivanova@mail.ru

Russian Federation PhD, senior research scientist of the Department of Neuroinfections and organic lesion of central nervous system of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 347-48-58

A. V. Surovtseva

Scientific and Research Institute of Children's Infections of FMBA of Russia, Saint-Petersburg, Russian Federation

Email: annasurovcev@mail.ru

Russian Federation postgraduate of the Department of Neuroinfections and organic lesion of central nervous system of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 234-38-23

A. V. Klimkin

Scientific and Research Institute of Children's Infections of FMBA of Russia, Saint-Petersburg, Russian Federation

Email: klinkinpark@mail.ru

Russian Federation junior research scientist of the Department of Functional methods of diagnosis and Imaging technologies of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 234-38-23

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