Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciences0869-60472414-3545"Paediatrician" Publishers LLC12010.15690/vramn.v68i11.841CENTRAL MOTOR PATHWAYS IN CHILDREN WITH MULTIPLE SCLEROSISVoitenkovV. B.MD, Head of the Department of Functional methods of diagnosis of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 234-38-23vlad203@inbox.ruKomantsevV. N.PhD, Head of the Department of Functional methods of diagnosis and Imaging technologies of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 234-38-23emgep@mail.ruSkripchenkoN. V.PhD, professor, Deputy director for Scientific Research of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 347-48-58niidi@niidi.ruIvanovaG. P.PhD, senior research scientist of the Department of Neuroinfections and organic lesion of central nervous system of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 347-48-58gpivanova@mail.ruSurovtsevaA. V.postgraduate of the Department of Neuroinfections and organic lesion of central nervous system of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 234-38-23annasurovcev@mail.ruKlimkinA. V.junior research scientist of the Department of Functional methods of diagnosis and Imaging technologies of FSBI Research Institute of Child Infections of Federal Medico-Biological Agency of Russia. Address: 9, Professor Popov Street, St. Petersburg, RF, 191014, tel.: +7 (812) 234-38-23klinkinpark@mail.ruScientific and Research Institute of Children's Infections of FMBA of Russia, Saint-Petersburg, Russian Federation121120136811343707082015Copyright © 1970, "Paediatrician" Publishers LLC1970<p class="Text05"><strong><em>Aim</em></strong><em>: to evaluate motor pathways involvement in children with multiple sclerosis. </em><strong><em>Patients and methods</em></strong><em>: we used transcranial magnetic stimulation method. 9 children with relapsing-remitting multiple sclerosis (mean duration 1,68 years) and 20 controls were enrolled. </em><strong><em>Results</em></strong><em>: in most of the cases findings in multiple sclerosis group were abnormal. More often polyphasic changes of the motor evoked potentials (MEP) shape (78% of the cases) and elevation of MEP threshold (88%) were seen. </em><strong><em>Conclusions</em></strong><em>: transcranial magnetic stimulation demonstrated high sensitivity in children with multiple sclerosis. Main neurophysiologic findings in multiple sclerosis in children may reflect altering membrane excitability of motor neurons and demyelinating lesions. Axonal damage in children with multiple sclerosis are less apparent.</em></p><p class="Text05"> </p>multiple sclerosischildrentranscranial magnetic stimulationmotor evoked potentialsaxonal damagedemyelinationрассеянный склерозтранскраниальная магнитная стимуляциявызванный моторный ответаксональное поражениедемиелинизация[1. Duquette P., Murray T.J., Pleines J.,Ebers G.C., Sadovnick D., Weldon P., Warren S., Paty D.W., Upton A., Hader W. Multiple sclerosis in childhood: Clinical profile in 125 patients. J. Pediatr. 1987; 111: 359–363.][2. Selcen D., Anlar B., Renda Y. Multiple sclerosis in childhood. Report of 16 cases. Eur. Neurol. 1996; 36: 79–84.][3. Lin K.L., Pascual-Leone A. Transcranial magnetic stimulation and its applications in children. Chang. Gung. Med. J. 2002; 25 (7): 424–436.][4. Barker A.T., Jalinous R., Freeston I.L. Non-invasive magnetic stimulation of human motor cortex. Lancet. 1985; 11: 1106–1107.][5. Voitenkov V.B., Komantsev V.N., Skripchenko N.V. Evoked potentials in assessing the nature and extent of damage to the central nervous system in critical conditions. Meditsina kriticheskikh sostoyanii = Emergency medicine. 2013; (2): 44–50.][6. Dan B., Christiaens F., Christophe C., Dachy B. Transcranial Magnetic Stimulation and Other Evoked Potentials in Pediatric Multiple Sclerosis. Pediatr.J. Neurol. 2000; 22: 136–138.][7. Skripchenko N.V., Ivanova G.P., Trofimova T.N., Murina E.A. The role of infection and the age factor in the development of leykoentsefalitov children. Zhurn. infektol. = Infectology journal. 2010; 2(2): 54–61.][8. Bejarano B., Bianco M., Gonzalez-Moron D. Computational classifiers for predicting the short-term course of multiple sclerosis. BMC Neurol. 2011; 11: 67.][9. Meyenburg J., Wilm B.J., Weck A. Petersen J., Gallus E., Mathys J., Schaetzle E., Schubert M., Boesiger P., von Meyenburg K., Goebels N., Kollias S. Spinal cord diffusion-tensor imaging and motor-evoked potentials in multiple sclerosis patients: Microstructural and Functional Asymmetry. Radiology. 2013; 18(7): 327–329.][10. Schlaeger R., D'Souza M., Schindler C. Grize L., Dellas S., Radue E.W., Kappos L., Fuhr P. Prediction of long-term disability in multiple sclerosis. Mult. Scler. 2012; 18 (1): 31–38.][11. Jones S.M., Streletz L.J., Raab V.E. Knobler R.L., Lublin F.D. Lower extremity motor evoked potentials in multiple sclerosis. Arch. Neurol. 1991; 48: 944–948.][12. Rico A., Audoin B., Franques J. Eusebio A., Reuter F., Malikova I., Ali Cherif A., Pouget J., Pelletier J., Attarian S. Motor evoked potentials in clinically isolated syndrome suggestive of multiple sclerosis. Mult. Scler. 2009; 15: 355–362.][13. Voitenkov V.B., Kartashev A.V. Neurophysiology of Brain Gliomas. World Applied Sciences J. 2013; 24 (6): 806-808.]