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Паратиреоидный гормон и подобные ему пептиды. Обзор литературы

https://doi.org/10.15690/vramn1104

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Аннотация

Широкая распространенность патологии околощитовидных желез и потребность в новых методах диагностики и лечения заставляет исследователей по всему миру все больше углубляться в патофизиологические механизмы. Ключевым гормоном, отвечающим за минеральные нарушения, является паратиреоидный гормон (ПТГ); кроме того, у человека имеется целое семейство сходных с ним по структуре молекул, привносящих свой вклад в поддержание фосфорно-кальциевого гомеостаза. К семейству относят ПТГ, паратгормонподобный пептид (ПТГпП) и тубероинфундибулярный пептид 39 (TIP39, также известный как PTH2). Гены, кодирующие данные пептиды, имеют участки высокогомологичных областей аминокислот в N(амино)-концевых рецепторсвязывающих участках каждого члена семейства, а также сохранную структуру их организации, что, по-видимому, связано с наличием одного родоначального гена. Многообразие классических и «неклассических» эффектов позволяет расширить представление о данных субстанциях и рассматривать их в качестве гормонов, выходящих за пределы регуляции фосфорно-кальциевого обмена. В обзоре представлена информация о структуре и биосинтезе этих пептидов, особенностях рецепторной передачи сигналов, а также о широком спектре их воздействия на организм человека.

Об авторах

Наталья Георгиевна Мокрышева
Национальный медицинский исследовательский центр эндокринологии
Россия

Доктор медицинских наук, профессор.

117036, Москва, ул. Дмитрия Ульянова, д. 11.

SPIN-код: 5624-3875



Юлия Александровна Крупинова
Национальный медицинский исследовательский центр эндокринологии
Россия

117036, Москва, ул. Дмитрия Ульянова, д. 11.

SPIN-код: 6279-8247



Елена Владимировна Ковалева
Национальный медицинский исследовательский центр эндокринологии
Россия

Аспирант.

117036, Москва, ул. Дмитрия Ульянова, д. 11; тел.: +7 (495) 500-00-63.

SPIN-код: 7387-6791



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Для цитирования:


Мокрышева Н.Г., Крупинова Ю.А., Ковалева Е.В. Паратиреоидный гормон и подобные ему пептиды. Обзор литературы. Вестник Российской академии медицинских наук. 2019;74(2):136-144. https://doi.org/10.15690/vramn1104

For citation:


Mokrysheva N.G., Krupinova J.A., Kovaleva E.V. The Parathyroid Hormone and Peptides Like It. Literature Review. Annals of the Russian academy of medical sciences. 2019;74(2):136-144. (In Russ.) https://doi.org/10.15690/vramn1104

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