Паратиреоидный гормон и подобные ему пептиды. Обзор литературы

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Аннотация

Широкая распространенность патологии околощитовидных желез и потребность в новых методах диагностики и лечения заставляет исследователей по всему миру все больше углубляться в патофизиологические механизмы. Ключевым гормоном, отвечающим за минеральные нарушения, является паратиреоидный гормон (ПТГ); кроме того, у человека имеется целое семейство сходных с ним по структуре молекул, привносящих свой вклад в поддержание фосфорно-кальциевого гомеостаза. К семейству относят ПТГ, паратгормонподобный пептид (ПТГпП) и тубероинфундибулярный пептид 39 (TIP39, также известный как PTH2). Гены, кодирующие данные пептиды, имеют участки высокогомологичных областей аминокислот в N(амино)-концевых рецепторсвязывающих участках каждого члена семейства, а также сохранную структуру их организации, что, по-видимому, связано с наличием одного родоначального гена. Многообразие классических и «неклассических» эффектов позволяет расширить представление о данных субстанциях и рассматривать их в качестве гормонов, выходящих за пределы регуляции фосфорно-кальциевого обмена. В обзоре представлена информация о структуре и биосинтезе этих пептидов, особенностях рецепторной передачи сигналов, а также о широком спектре их воздействия на организм человека.

Об авторах

Наталья Георгиевна Мокрышева

Национальный медицинский исследовательский центр эндокринологии

Email: parathyroid.enc@gmail.com
ORCID iD: 0000-0002-9717-9742

Доктор медицинских наук, профессор.

117036, Москва, ул. Дмитрия Ульянова, д. 11.

SPIN-код: 5624-3875

Россия

Юлия Александровна Крупинова

Национальный медицинский исследовательский центр эндокринологии

Email: j.krupinova@gmail.com
ORCID iD: 0000-0001-7963-5022

117036, Москва, ул. Дмитрия Ульянова, д. 11.

SPIN-код: 6279-8247

Россия

Елена Владимировна Ковалева

Национальный медицинский исследовательский центр эндокринологии

Автор, ответственный за переписку.
Email: elen.v.kovaleva@gmail.com
ORCID iD: 0000-0002-9258-2591

Аспирант.

117036, Москва, ул. Дмитрия Ульянова, д. 11; тел.: +7 (495) 500-00-63.

SPIN-код: 7387-6791

Россия

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