Evaluation of the lipid peroxidation reactions activity in middle-aged men with chronic gastritis on the background of H. pylori infection

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  • Authors: Darenskaya M.A.1, Smirnova O.V.2, Kasparov E.V.2, Grebenkina L.A.1, Sinyakov A.A.2, Kolesnikova L.I.1,3, Kolesnikov S.I.1,4
  • Affiliations:
    1. Scientific Centre for Family Health and Human Reproduction Problems
    2. Krasnoyarsk Science Center SB RAS
    3. Irkutsk State University
    4. Lomonosov Moscow State University
  • Issue: Vol 74, No 3 (2019)
  • Pages: 149-156
  • Section: BIOCHEMISTRY: CURRENT ISSUES
  • URL: https://vestnikramn.spr-journal.ru/jour/article/view/1087
  • DOI: https://doi.org/10.15690/vramn1087
  • Cite item
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Abstract


Background: There is not enough information about the course of the processes of lipid peroxidation-antioxidant defense in middle-aged men who are at risk of developing gastric cancer on the Correa cascade. Aims: To analyze of the processes of lipid peroxidation activity and antioxidant defense in men with chronic gastritis and chronic atrophic gastritis in combination with and without the presence of Helicobacter pylori. Materials and methods: 173 middle-aged men with an established diagnosis of chronic gastritis were examined, which were divided into 4 groups: group 1 ― patients with chronic gastritis without H. pylori (n=58), group 2 ― patients with chronic gastritis in combination with H. pylori (n=61), group 3 ― patients with chronic atrophic gastritis without H. pylori (n=28), group 4 ― patients with chronic atrophic gastritis in combination with H. pylori (n=26). Evaluation of the content of parameters of the lipid peroxidation system and the antioxidant components activity using spectrophotometric research methods was carried out. For statistical analysis, the software package Statistica 7.0 (Stat Soft, USA) was used. The study was conducted during 2013−2015. Results: Infection H. pylori with chronic and chronic atrophic gastritis accompanied by significant changes in the system of lipid peroxidation, and antioxidant defense components in the form of primary and accumulation of end products, insufficient activity of antioxidant enzymes ― superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and reducing content of reduced glutathione. The use of an integrating factor to assess the severity of prooxidant activity confirms the development of antioxidant deficiency in patients of these groups. Conclusions: In patients with chronic and chronic atrophic gastritis, combined with H. Pylori infection, a more pronounced progression of oxidative stress reactions and a significant lack of antioxidant factors were found in comparison with patients with these forms of gastritis without H. pylori.


Marina A. Darenskaya

Scientific Centre for Family Health and Human Reproduction Problems

Author for correspondence.
Email: marina_darenskaya@inbox.ru
ORCID iD: 0000-0003-3255-2013

Russian Federation

PhD.

16, Timiryazeva street, 664003 Irkutsk.

tel.: +7 (3952) 20-73-67

SPIN-код: 3327-4213

Olga V. Smirnova

Krasnoyarsk Science Center SB RAS

Email: iphr@sbamsr.irk.ru
ORCID iD: 0000-0003-3992-9207

Russian Federation

MD, PhD.

Krasnoyarsk.

SPIN-код: 2198-0265

Edward V. Kasparov

Krasnoyarsk Science Center SB RAS

Email: iphr@sbamsr.irk.ru
ORCID iD: 0000-0002-5988-1688

Russian Federation

MD, PhD, Professor.

Krasnoyarsk.

Lyudmila A. Grebenkina

Scientific Centre for Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
ORCID iD: 0000-0002-1263-5527

Russian Federation

PhD.

16, Timiryazeva street, 664003 Irkutsk.

SPIN-код: 6194-5785

Aleksandr A. Sinyakov

Krasnoyarsk Science Center SB RAS

Email: iphr@sbamsr.irk.ru
ORCID iD: 0000-0002-4474-1893

Russian Federation

PhD.

Krasnoyarsk.

SPIN-код: 8600-0003

Lubov I. Kolesnikova

Scientific Centre for Family Health and Human Reproduction Problems; Irkutsk State University

Email: iphr@sbamsr.irk.ru
ORCID iD: 0000-0003-3354-2992

Russian Federation

MD, PhD, Professor.

Irkutsk.

SPIN-код: 1584-0281

Sergey I. Kolesnikov

Scientific Centre for Family Health and Human Reproduction Problems; Lomonosov Moscow State University

Email: iphr@sbamsr.irk.ru
ORCID iD: 0000-0003-2124-6328

Russian Federation

MD, PhD, Professor.

Irkutsk; Moscow.

SPIN-код: 1752-6695

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