USE OF MATHEMATICAL MODELS INFRARED SPECTROSCOPY SERUM IN THE DIFFERENTIAL DIAGNOSIS OF ULCERATIVE COLITIS AND CROHN'S DISEASE IN CHILDREN

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Abstract

Relevance of research. Inflammatory bowel diseases are among the most severe pathologies in pediatric gastroenterology, often lead to disability. Despite the similarity of the clinic, pathogenetic mechanisms, the question of the differential diagnosis of ulcerative colitis and Crohn's disease is relevant in view of their different prognosis and treatment strategy. In recent years, in medical uses infrared spectroscopy of blood serum for the differential diagnosis of various inflammatory diseases, benign and malignant tumors. Besides finding increasing application of mathematical methods for data processing, the so-called mathematical modeling of pathological processes, allowing objectify the survey results for a more accurate diagnosis and prognosis of pathological processes. Objective: improving the differential diagnosis of ulcerative colitis and Crohn's disease in children. Patients: 21 children with ulcerative colitis, 56 children with Crohn's disease and 34 healthy children. The method of infrared spectroscopy of serum and mathematical modeling results through multivariate entropy analysis. Results: the obtained spectral characteristics of blood serum in children with ulcerative colitis and Crohn's disease and in healthy children, as well as "images of disease" in these pathologies. Conclusion: The use of this medical technology reduced the time of diagnosis, which contributes to the timely choice of rational treatment strategies and provides an opportunity to avoid the development of complications, worsening of the disease.

 

About the authors

E. N. Fedulova

Nizhny Novgorod Research Institute of Pediatric Gastroenterology, Russian Federation

Author for correspondence.
Email: fedulova04@mail.ru
MD, Head of the Department of Clinic of Colon Pathology of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950; tel.: +7 (831) 436-67-06 Россия

A. S. Gordetsov

Nizhny Novgorod State Medical Academy Russian Federation

Email: chem@gma.nnov.ru
PhD, professor, Head of the Department of General Chemistry of SBEI HPE “Nizhnii Novgorod State Medical University” of Ministry of Health, Russian Federation. Address: 190a, Rodionov Street, Nizhny Novgorod, RF, 603093; tel.: +7 (831) 438-80-05 Россия

O. V. Fedorova

Nizhny Novgorod Research Institute of Pediatric Gastroenterology, Russian Federation

Email: olgafedorva@mail.ru
senior research scientist of Clinic of Colon Pathology of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950; tel.: +7 (831) 436-67-06 Россия

L. V. Korkotashvili

Nizhny Novgorod Research Institute of Pediatric Gastroenterology, Russian Federation

Email: niidetgastro@mail.ru
MD, Head of Laboratorial and Diagnostic Department of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950; tel.: +7 (831) 436-54-60 Россия

O. A. Tutina

Nizhny Novgorod Research Institute of Pediatric Gastroenterology, Russian Federation

Email: tutina_oa@mail.ru
MD, research scientist of Clinic of Colon Pathology of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950; tel.: +7 (831) 436-67-06 Россия

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