NAD+-CONVERTING ENZYMES IN NEURONAL AND GLIAL CELLS: CD38 AS A NOVEL TARGET FOR NEUROPROTECTION

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Abstract

The review contains current data on molecular mechanisms which control NAD+ homeostasis in brain cells. It also deals with the role of NAD+-converting enzymes in regulation of functional activity, viability and intercellular communication of neuronal and glial cells. Special attention is paid to involvement of CD38 into regulation of NAD+ levels in brain cells in normal and pathological conditions.

 

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About the authors

A. B. Salmina

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Ministry of Public Health and Social Development, Russian Federation

Author for correspondence.
Email: allasalmina@mail.ru
доктор медицинских наук, профессор, заведующая кафедрой биохимии с курсами меди- цинской, фармацевтической и токсикологической химии, проректор по инновационному развитию и междуна- родной деятельности ГБОУ ВПО КрасГМУ им. проф. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1 Тел.: (391) 228-07-69 Россия

A. I. Inzhutova

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Ministry of Public Health and Social Development, Russian Federation

Email: a_morgun@mail.ru
кандидат медицинских наук, научный сотрудник НИИ молекулярной медицины и патобиохимии, старший преподаватель кафедры биохимии с курсами медицинской, фармацевтической и токсико- логической химии ГБОУ ВПО КрасГМУ им. проф. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1 Россия

A. V. Morgun

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Ministry of Public Health and Social Development, Russian Federation

Email: a_morgun@mail.ru
кандидат медицинских наук, ассистент кафедры педатрии ИПО ГБОУ ВПО КрасГМУ им. проф. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1 Тел.: (391) 243-39-52 Россия

O. S. Okuneva

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Ministry of Public Health and Social Development, Russian Federation

Email: olesyaokuneva@gmail.com
кандидат медицинских наук, старший преподаватель кафедры биохимии с курсами меди- цинской, фармацевтической и токсикологической химии, ГБОУ ВПО КрасГМУ им. проф. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1 Тел.: (391) 228-07-69 Россия

N. A. Malinovskaya

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Ministry of Public Health and Social Development, Russian Federation

Email: konsuelo81@mail.ru
кандидат медицинских наук, доцент кафедры биохимии с курсами медицин- ской, фармацевтической и токсикологической химии, научный сотрудник НИИ молекулярной медицины и пато- биохимии ГБОУ ВПО КрасГМУ им. проф. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1 Тел.: (391) 228-07-69 Россия

O. L. Lopatina

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Ministry of Public Health and Social Development, Russian Federation

Email: ol.lopatina@gmail.com
кандидат медицинских наук, старший преподаватель кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии, ГБОУ ВПО КрасГМУ им. проф. В.Ф. Войно- Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1 Тел.: (391) 228-07-69 Россия

M. M. Petrova

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Ministry of Public Health and Social Development, Russian Federation

Email: stk99@yandex.ru
доктор медицинских наук, профессор, заведующая кафедрой поликлинической терапии и семейной медицины, проректор по научной работе ГБОУ ВПО КрасГМУ им. проф. В.Ф. Войно- Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1 Тел.: (391) 228-07-69 Россия

T. E. Taranunushenko

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Ministry of Public Health and Social Development, Russian Federation

Email: tetar@rambler.ru
доктор медицинских наук, профессор, заведующая кафедрой педиатрии ИПО ГБОУ ВПО КрасГМУ им. проф. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1 Тел.: (391) 243-39-52 Россия

A. A. Fursov

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Ministry of Public Health and Social Development, Russian Federation

Email: fursov_alex@mail.ru
кандидат медицинских наук, ассистент кафедры анестезиологии и реаниматологии ГБОУ ВПО КрасГМУ им. проф. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1 Тел.: (391) 2283468 Россия

N. V. Kuvacheva

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Ministry of Public Health and Social Development, Russian Federation

Email: natalya.kuvacheva@gmail.com
During writing this review, the authors have been supporting by the grant of the Federal Program «Scientific and pedagogical specialists of innovative Russia» (N 8061, 2012–2013). Россия

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