Использование стволовых клеток в терапии дегенерации межпозвонкового диска

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Статья представляет собой обзор современных литературных данных, посвященных применению стволовых клеток в терапии дегенеративных процессов межпозвонковых дисков. Чаще всего причиной развития болевого синдрома в спине является дегенеративное поражение межпозвонковых дисков. Дегенерация дисков в настоящее время представляет собой одну из основных причин утраты трудоспособности населения. Нередко многие методы лечения не позволяют получить ожидаемых результатов, так как в большинстве своем они имеют симптоматическую направленность и не влияют на патогенез процесса. Авторами изложены современные данные о молекулярно-клеточных механизмах дегенерации межпозвонковых дисков. Представлен анализ экспериментальных исследований, проводимых в мире, демонстрирующих возможности клеточной терапии дегенеративных процессов дисков на примере использования мезенхимальных, жировых, синовиальных и костномозговых стволовых клеток. Обозначены актуальные, остающиеся нерешенными вопросы, что обусловливает необходимость проведения дальнейших экспериментальных и клинических исследований при лечении данной патологии.

Об авторах

В. А. Бывальцев

Иркутский государственный медицинский университет;
Дорожная клиническая больница на ст. Иркутск-Пассажирский;
Иркутский научный центр хирургии и травматологии;
Иркутская государственная академия последипломного образования

Email: byval75vadim@yandex.ru
ORCID iD: 0000-0003-4349-7101

доктор медицинских наук, главный нейрохирург Департамента здравоохранения ОАО «РЖД», заведующий курсом нейрохирургии Иркутского государственного медицинского университета,

заведующий научно-клиническим отделом нейрохирургии и ортопедии Иркутского научного центра хирургии и травматологии,

профессор кафедры травматологии, ортопедии и нейрохирургии Иркутской государственной медицинской академии последипломного образования,

664082, Иркутск, ул. Боткина, д. 10

Россия

И. А. Степанов

Иркутский государственный медицинский университет

Автор, ответственный за переписку.
Email: edmoilers@mail.ru
ORCID iD: 0000-0001-9039-9147

аспирант курса нейрохирургии,

664003, Иркутск, ул. Красного Восстания, д. 14

Россия

Л. А. Бардонова

Иркутский государственный медицинский университет

Email: lyudmila15@ibox.ru

аспирантка курса нейрохирургии,

664003, Иркутск, ул. Красного Восстания, д. 14

Россия

Е. Г. Белых

Иркутский государственный медицинский университет;
Иркутский научный центр хирургии и травматологии

Email: e.belykh@yandex.ru
ORCID iD: 0000-0003-2060-5739

ассистент курса нейрохирургии;

аспирант,

664082, Иркутск, ул. Боткина, д. 10

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