Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC72910.15690/vramn729CELL TRANSPLANTOLOGY AND TISSUE ENGINEERING: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ КЛЕТОЧНОЙ ТРАНСПЛАНТОЛОГИИ И ТКАНЕВОЙ ИНЖЕНЕРИИThe Use of Stem Cells in the Treatment of Intervertebral Disc DegenerationИспользование стволовых клеток в терапии дегенерации межпозвонкового дискаhttps://orcid.org/0000-0003-4349-7101ByvaltsevV. A.БывальцевВ. А.
Russian Federation

Irkutsk

доктор медицинских наук, главный нейрохирург Департамента здравоохранения ОАО «РЖД», заведующий курсом нейрохирургии Иркутского государственного медицинского университета,

заведующий научно-клиническим отделом нейрохирургии и ортопедии Иркутского научного центра хирургии и травматологии,

профессор кафедры травматологии, ортопедии и нейрохирургии Иркутской государственной медицинской академии последипломного образования,

664082, Иркутск, ул. Боткина, д. 10

byval75vadim@yandex.ruhttps://orcid.org/0000-0001-9039-9147StepanovI. A.СтепановИ. А.
Russian Federation

Irkutsk

аспирант курса нейрохирургии,

664003, Иркутск, ул. Красного Восстания, д. 14

edmoilers@mail.ruBardonovaL. A.БардоноваЛ. А.
Russian Federation

Irkutsk

аспирантка курса нейрохирургии,

664003, Иркутск, ул. Красного Восстания, д. 14

lyudmila15@ibox.ruhttps://orcid.org/0000-0003-2060-5739BelykhE. G.БелыхЕ. Г.

Irkutsk

ассистент курса нейрохирургии;

аспирант,

664082, Иркутск, ул. Боткина, д. 10

e.belykh@yandex.ruIrkutsk State Medical UniversityИркутский государственный медицинский университетRailway Clinical Hospital on the station Irkutsk-Passazhirskiy of Russian Railways Ltd.Дорожная клиническая больница на ст. Иркутск-ПассажирскийIrkutsk Scientific Center of Surgery and TraumatologyИркутский научный центр хирургии и травматологииIrkutsk State Academy of Postgraduate EducationИркутская государственная академия последипломного образования151120167153593661909201613102016Copyright ©; 2016, "Paediatrician" Publishers LLCCopyright ©; 2016, Издательство "Педиатръ"2016"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/729

The paper presents a review of current data on the use of stem cells in the treatment of intervertebral disc degeneration. Acute spinal pain is often a consequence of the pathology affecting the intervertebral disc. Many applied therapeutic techniques do not provide effective results as expected because most of them address symptoms, but do not treat the underlying disease. We have outlined current findings on the molecular mechanisms of intervertebral disc degeneration, analyzed international experimental studies demonstrating the feasibility of a stem cell therapy for intervertebral disc degeneration. The conducted studies reported on the clinical application of mesenchymal stem cells or stem cells derived from adipose, synovium, and bone marrow tissue. The most pressing and undetermined issues that require further experimental and clinical studies are indicated and defined in the article.

Статья представляет собой обзор современных литературных данных, посвященных применению стволовых клеток в терапии дегенеративных процессов межпозвонковых дисков. Чаще всего причиной развития болевого синдрома в спине является дегенеративное поражение межпозвонковых дисков. Дегенерация дисков в настоящее время представляет собой одну из основных причин утраты трудоспособности населения. Нередко многие методы лечения не позволяют получить ожидаемых результатов, так как в большинстве своем они имеют симптоматическую направленность и не влияют на патогенез процесса. Авторами изложены современные данные о молекулярно-клеточных механизмах дегенерации межпозвонковых дисков. Представлен анализ экспериментальных исследований, проводимых в мире, демонстрирующих возможности клеточной терапии дегенеративных процессов дисков на примере использования мезенхимальных, жировых, синовиальных и костномозговых стволовых клеток. Обозначены актуальные, остающиеся нерешенными вопросы, что обусловливает необходимость проведения дальнейших экспериментальных и клинических исследований при лечении данной патологии.

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