ЛЕЧЕНИЕ ВИЧ-ИНФЕКЦИИ С ПОМОЩЬЮ ГЕННОЙ ТЕРАПИИ

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Аннотация

Современные методы лечения ВИЧ-инфекции позволяют сдерживать скорость развития заболевания, но не приводят к его излечению. Антиретровирусная терапия является пожизненной, дорогостоящей и сопровождается накоплением побочных эффектов. Последние достижения науки позволили предложить принципиально новый подход к лечению ВИЧ-инфекции — генную терапию. Настоящая публикация посвящена одному из направлений генной терапии ВИЧ, которое получило название «внутриклеточная иммунизация». В основе этого направления лежит идея введения антивирусных генов в чувствительные к ВИЧ клетки. В статье рассмотрены механизмы действия различных антивирусных генетических агентов, обсуждаются вопросы, связанные с выбором клеток-мишеней и способом доставки терапевтических генов. Представлены результаты клинических испытаний некоторых генотерапевтических препаратов для лечения ВИЧ-инфекции.

 

Об авторах

Д. В. Глазкова

ФГБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора, Москва

Автор, ответственный за переписку.
Email: glazkova@pcr.ru
кандидат биологических наук, научный сотрудник отдела молекулярной диагностики и эпидемиологии ФБУН ЦНИИ эпидемиологии Роспотребнадзора Адрес: 111123, Москва, ул. Новогиреевская, 3А Россия

Е. В. Богословская

ФГБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора, Москва

Email: lenabo@pcr.ru
кандидат медицинских наук, старший научный сотрудник отдела молекулярной диагностики и эпидемиологии ФБУН ЦНИИ эпидемиологии Роспотребнадзора Адрес: 111123, Москва, ул. Новогиреевская, д. 3А E-mail: lenabo@pcr.ru Тел./ факс: (495) 305-54-23 Россия

М. Л. Маркелов

ФГБУ «Институт медицины труда» РАМН, Москва

Email: markelov@pcr.ru
кандидат биологических наук, старший научный сотрудник лаборатории постге- номных технологий Института медицины труда РАМН Адрес: 105275, Москва, проспект Буденного, 31 Россия

Г. А. Шипулин

ФГБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора, Москва

Email: german@pcr.ru
кандидат медицинских наук, заведующий отделом молекулярной диагностики и эпидемиологии ФБУН ЦНИИ эпидемиологии Роспотребнадзора Адрес: 111123, Москва, ул. Новогиреевская, 3А Россия

В. В. Покровский

ФГБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора, Москва

Email: info@pcr.ru
академик РАМН, заместитель директора ФБУН ЦНИИ эпидемиологии Роспотребнадзора по научной работе Адрес: 111123, Москва, ул. Новогиреевская, 3А Тел.: (495) 974-96-46, факс: (495) 305-54-23 Россия

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